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Chemical Compound Review

Chonsurid     (2S,3S,4S,5R,6R)-6- [(2R,3R,4R,5R,6R)-3...

Synonyms: AG-H-72973, HMDB00580, AC1L2NNP, LS-53338, CTK5G8580, ...
 
 
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Disease relevance of Chondroitin sulfate

 

Psychiatry related information on Chondroitin sulfate

 

High impact information on Chondroitin sulfate

 

Chemical compound and disease context of Chondroitin sulfate

 

Biological context of Chondroitin sulfate

 

Anatomical context of Chondroitin sulfate

  • Immunofluorescent staining of a pericellular matrix produced by cultured human embryonic skin fibroblasts showed a codistribution among fibronectin, heparan sulfate proteoglycans and part of the chondroitin sulfate in a fibrillar network [21].
  • Silver grains are particularly dense near cells cultured on chondroitin sulfate [22].
  • Chondroitin sulphate proteoglycans are widespread connective tissue components and chemical analysis of cartilage and other proteoglycans has demonstrated molecular speciation involving the degree and position of sulphation of the carbohydrate chains [23].
  • Undersulphated and oversulphated chondroitin sulphate chains have been implicated in other biological processes, however, including adhesion of erythrocytes infected with malaria parasite to human placenta and regulation of neural development [24].
  • To test the functional effects of degrading chondroitin sulphate (CS)-GAG after spinal cord injury, we delivered chondroitinase ABC (ChABC) to the lesioned dorsal columns of adult rats [25].
 

Associations of Chondroitin sulfate with other chemical compounds

 

Gene context of Chondroitin sulfate

 

Analytical, diagnostic and therapeutic context of Chondroitin sulfate

References

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  24. Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans. Mizuguchi, S., Uyama, T., Kitagawa, H., Nomura, K.H., Dejima, K., Gengyo-Ando, K., Mitani, S., Sugahara, K., Nomura, K. Nature (2003) [Pubmed]
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  31. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. Brambilla, R., Bracchi-Ricard, V., Hu, W.H., Frydel, B., Bramwell, A., Karmally, S., Green, E.J., Bethea, J.R. J. Exp. Med. (2005) [Pubmed]
  32. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Eisenmann, K.M., McCarthy, J.B., Simpson, M.A., Keely, P.J., Guan, J.L., Tachibana, K., Lim, L., Manser, E., Furcht, L.T., Iida, J. Nat. Cell Biol. (1999) [Pubmed]
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  34. The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Aspberg, A., Miura, R., Bourdoulous, S., Shimonaka, M., Heinegârd, D., Schachner, M., Ruoslahti, E., Yamaguchi, Y. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  35. Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells. Otsu, K., Nakano, T., Kanakura, Y., Asai, H., Katz, H.R., Austen, K.F., Stevens, R.L., Galli, S.J., Kitamura, Y. J. Exp. Med. (1987) [Pubmed]
  36. Bacterial lipopolysaccharides induce in vitro degradation of cartilage matrix through chondrocyte activation. Jasin, H.E. J. Clin. Invest. (1983) [Pubmed]
  37. The melanoma proteoglycan: restricted expression on microspikes, a specific microdomain of the cell surface. Garrigues, H.J., Lark, M.W., Lara, S., Hellström, I., Hellström, K.E., Wight, T.N. J. Cell Biol. (1986) [Pubmed]
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  39. The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. Friedlander, D.R., Milev, P., Karthikeyan, L., Margolis, R.K., Margolis, R.U., Grumet, M. J. Cell Biol. (1994) [Pubmed]
 
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