The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Chonsurid     (2S,3S,4S,5R,6R)-6- [(2R,3R,4R,5R,6R)-3...

Synonyms: AG-H-72973, HMDB00580, AC1L2NNP, LS-53338, CTK5G8580, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Chondroitin sulfate


Psychiatry related information on Chondroitin sulfate


High impact information on Chondroitin sulfate


Chemical compound and disease context of Chondroitin sulfate


Biological context of Chondroitin sulfate


Anatomical context of Chondroitin sulfate

  • Immunofluorescent staining of a pericellular matrix produced by cultured human embryonic skin fibroblasts showed a codistribution among fibronectin, heparan sulfate proteoglycans and part of the chondroitin sulfate in a fibrillar network [21].
  • Silver grains are particularly dense near cells cultured on chondroitin sulfate [22].
  • Chondroitin sulphate proteoglycans are widespread connective tissue components and chemical analysis of cartilage and other proteoglycans has demonstrated molecular speciation involving the degree and position of sulphation of the carbohydrate chains [23].
  • Undersulphated and oversulphated chondroitin sulphate chains have been implicated in other biological processes, however, including adhesion of erythrocytes infected with malaria parasite to human placenta and regulation of neural development [24].
  • To test the functional effects of degrading chondroitin sulphate (CS)-GAG after spinal cord injury, we delivered chondroitinase ABC (ChABC) to the lesioned dorsal columns of adult rats [25].

Associations of Chondroitin sulfate with other chemical compounds


Gene context of Chondroitin sulfate


Analytical, diagnostic and therapeutic context of Chondroitin sulfate


  1. Human melanoma proteoglycan: expression in hybrids controlled by intrinsic and extrinsic signals. Rettig, W.J., Real, F.X., Spengler, B.A., Biedler, J.L., Old, L.J. Science (1986) [Pubmed]
  2. Chondroitin sulfate as a regulator of neuronal patterning in the retina. Brittis, P.A., Canning, D.R., Silver, J. Science (1992) [Pubmed]
  3. Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo. Leroux, J.Y., Guerassimov, A., Cartman, A., Delaunay, N., Webber, C., Rosenberg, L.C., Banerjee, S., Poole, A.R. J. Clin. Invest. (1996) [Pubmed]
  4. Multiple domains of the large fibroblast proteoglycan, versican. Zimmermann, D.R., Ruoslahti, E. EMBO J. (1989) [Pubmed]
  5. Pericellular coat of chick embryo chondrocytes: structural role of hyaluronate. Goldberg, R.L., Toole, B.P. J. Cell Biol. (1984) [Pubmed]
  6. Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease. DeWitt, D.A., Silver, J., Canning, D.R., Perry, G. Exp. Neurol. (1993) [Pubmed]
  7. Spatial and temporal changes in chondroitin sulfate distribution in the sclerotome play an essential role in the formation of migration patterns of mouse neural crest cells. Kubota, Y., Morita, T., Kusakabe, M., Sakakura, T., Ito, K. Dev. Dyn. (1999) [Pubmed]
  8. The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. Naujokas, M.F., Morin, M., Anderson, M.S., Peterson, M., Miller, J. Cell (1993) [Pubmed]
  9. A hepatic reticuloendothelial cell receptor specific for SO4-4GalNAc beta 1,4GlcNAc beta 1,2Man alpha that mediates rapid clearance of lutropin. Fiete, D., Srivastava, V., Hindsgaul, O., Baenziger, J.U. Cell (1991) [Pubmed]
  10. Immunocytochemical localization of native chondroitin-sulfate in tissues and cultured cells using specific monoclonal antibody. Avnur, Z., Geiger, B. Cell (1984) [Pubmed]
  11. Codistribution of heparan sulfate proteoglycan, laminin, and fibronectin in the extracellular matrix of normal rat kidney cells and their coordinate absence in transformed cells. Hayman, E.G., Oldberg, A., Martin, G.R., Ruoslahti, E. J. Cell Biol. (1982) [Pubmed]
  12. Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin. Iida, J., Skubitz, A.P., Furcht, L.T., Wayner, E.A., McCarthy, J.B. J. Cell Biol. (1992) [Pubmed]
  13. A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion. Faassen, A.E., Schrager, J.A., Klein, D.J., Oegema, T.R., Couchman, J.R., McCarthy, J.B. J. Cell Biol. (1992) [Pubmed]
  14. Doxorubicin conjugated with a monoclonal antibody directed to a human melanoma-associated proteoglycan suppresses the growth of established tumor xenografts in nude mice. Yang, H.M., Reisfeld, R.A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  15. Variation in glycosaminoglycan components of breast tumors. Takeuchi, J., Sobue, M., Sato, E., Shamoto, M., Miura, K. Cancer Res. (1976) [Pubmed]
  16. Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes. Rogerson, S.J., Chaiyaroj, S.C., Ng, K., Reeder, J.C., Brown, G.V. J. Exp. Med. (1995) [Pubmed]
  17. Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis. MacDermott, R.P., Schmidt, R.E., Caulfield, J.P., Hein, A., Bartley, G.T., Ritz, J., Schlossman, S.F., Austen, K.F., Stevens, R.L. J. Exp. Med. (1985) [Pubmed]
  18. Platelet interaction with modified articular cartilage. Its possible relevance to joint repair. Zucker-Franklin, D., Drosenberg, L. J. Clin. Invest. (1977) [Pubmed]
  19. Functional characterization of chondroitin sulfate proteoglycans of brain: interactions with neurons and neural cell adhesion molecules. Grumet, M., Flaccus, A., Margolis, R.U. J. Cell Biol. (1993) [Pubmed]
  20. Conditioning of native substrates by chondroitin sulfate proteoglycans during cardiac mesenchymal cell migration. Funderburg, F.M., Markwald, R.R. J. Cell Biol. (1986) [Pubmed]
  21. Structure of the pericellular matrix: association of heparan and chondroitin sulfates with fibronectin-procollagen fibers. Hedman, K., Johansson, S., Vartio, T., Kjellén, L., Vaheri, A., Höök, M. Cell (1982) [Pubmed]
  22. Spontaneous glycosylation of glycosaminoglycan substrates by adherent fibroblasts. Turley, E.A., Roth, S. Cell (1979) [Pubmed]
  23. Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues. Couchman, J.R., Caterson, B., Christner, J.E., Baker, J.R. Nature (1984) [Pubmed]
  24. Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans. Mizuguchi, S., Uyama, T., Kitagawa, H., Nomura, K.H., Dejima, K., Gengyo-Ando, K., Mitani, S., Sugahara, K., Nomura, K. Nature (2003) [Pubmed]
  25. Chondroitinase ABC promotes functional recovery after spinal cord injury. Bradbury, E.J., Moon, L.D., Popat, R.J., King, V.R., Bennett, G.S., Patel, P.N., Fawcett, J.W., McMahon, S.B. Nature (2002) [Pubmed]
  26. Cardiac catabolic factors: the degradation of heart valve intercellular matrix. Decker, R.S., Dingle, J.T. Science (1982) [Pubmed]
  27. The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin. Leteux, C., Chai, W., Loveless, R.W., Yuen, C.T., Uhlin-Hansen, L., Combarnous, Y., Jankovic, M., Maric, S.C., Misulovin, Z., Nussenzweig, M.C., Feizi, T. J. Exp. Med. (2000) [Pubmed]
  28. IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells. Razin, E., Mencia-Huerta, J.M., Stevens, R.L., Lewis, R.A., Liu, F.T., Corey, E., Austen, K.F. J. Exp. Med. (1983) [Pubmed]
  29. Interaction of astrochondrin with extracellular matrix components and its involvement in astrocyte process formation and cerebellar granule cell migration. Streit, A., Nolte, C., Rásony, T., Schachner, M. J. Cell Biol. (1993) [Pubmed]
  30. Immunoelectron microscopic localization of hyaluronic acid-binding region and link protein epitopes in brain. Ripellino, J.A., Margolis, R.U., Margolis, R.K. J. Cell Biol. (1989) [Pubmed]
  31. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. Brambilla, R., Bracchi-Ricard, V., Hu, W.H., Frydel, B., Bramwell, A., Karmally, S., Green, E.J., Bethea, J.R. J. Exp. Med. (2005) [Pubmed]
  32. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Eisenmann, K.M., McCarthy, J.B., Simpson, M.A., Keely, P.J., Guan, J.L., Tachibana, K., Lim, L., Manser, E., Furcht, L.T., Iida, J. Nat. Cell Biol. (1999) [Pubmed]
  33. The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and is upregulated in dystrophic muscle. Bowe, M.A., Mendis, D.B., Fallon, J.R. J. Cell Biol. (2000) [Pubmed]
  34. The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Aspberg, A., Miura, R., Bourdoulous, S., Shimonaka, M., Heinegârd, D., Schachner, M., Ruoslahti, E., Yamaguchi, Y. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  35. Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells. Otsu, K., Nakano, T., Kanakura, Y., Asai, H., Katz, H.R., Austen, K.F., Stevens, R.L., Galli, S.J., Kitamura, Y. J. Exp. Med. (1987) [Pubmed]
  36. Bacterial lipopolysaccharides induce in vitro degradation of cartilage matrix through chondrocyte activation. Jasin, H.E. J. Clin. Invest. (1983) [Pubmed]
  37. The melanoma proteoglycan: restricted expression on microspikes, a specific microdomain of the cell surface. Garrigues, H.J., Lark, M.W., Lara, S., Hellström, I., Hellström, K.E., Wight, T.N. J. Cell Biol. (1986) [Pubmed]
  38. Chondroitin sulfate at the plasma membranes of cultured fibroblasts. Hedman, K., Christner, J., Julkunen, I., Vaheri, A. J. Cell Biol. (1983) [Pubmed]
  39. The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. Friedlander, D.R., Milev, P., Karthikeyan, L., Margolis, R.K., Margolis, R.U., Grumet, M. J. Cell Biol. (1994) [Pubmed]
WikiGenes - Universities