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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death.

Galectin-1, an endogenous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and murine thymocytes and T cells. Galectin-1 binds to several glycoproteins on the T cell surface, including CD7. However, the T cell surface glycoprotein receptors responsible for delivering the galectin-1 death signal have not been identified. We show that CD7 is required for galectin-1-mediated death. This demonstrates a novel function for CD7 as a death trigger and identifies galectin-1/CD7 as a new biologic death signaling pair.[1]

References

  1. CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. Pace, K.E., Hahn, H.P., Pang, M., Nguyen, J.T., Baum, L.G. J. Immunol. (2000) [Pubmed]
 
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