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Alexeeva, I. et al.

N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship.

Several N4-derivatives of 6-azacytidine were synthesized using of VorbrÃ¼ggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.[1]

References

N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship. Alexeeva, I., Palchikovskaya, L., Shalamay, A., Nosach, L., Zhovnovataya, V., Povnitsa, O., Dyachenko, N. Acta Biochim. Pol. (2000) [Pubmed]

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