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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

CEO1, a new protein from Arabidopsis thaliana, protects yeast against oxidative damage.

The Saccharomyces cerevisiae strain WYT, deficient in the YAP1 transcription factor, was used in a molecular screen to identify genes from Arabidopsis thaliana that could overcome the oxidative stress-sensitive phenotype of these yeast cells. A cDNA named CEO1 increased the tolerance to oxidative damage caused by tert-butylhydroperoxide of both the Yap1(-) mutant and the wild-type yeast. Additionally, in Yap1(-) yeast, CEO1 also induced cross-tolerance to oxidative damage caused by hydrogen peroxide and diamide. CEO1 was assigned as being part of a small gene family that, until now, is exclusively restricted to plants. In Arabidopsis, CEO1 was produced in all organs, especially in roots and stems. By using the yeast two-hybrid system, proteins that specifically interact with CEO1 in yeast were identified, and putative DNA-binding proteins were consistently recovered.[1]


  1. CEO1, a new protein from Arabidopsis thaliana, protects yeast against oxidative damage. Belles-Boix, E., Babiychuk, E., Van Montagu, M., Inzé, D., Kushnir, S. FEBS Lett. (2000) [Pubmed]
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