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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Nucleophosmin/ B23 is a target of CDK2/cyclin E in centrosome duplication.

In animal cells, duplication of centrosomes and DNA is coordinated. Since CDK2/cyclin E triggers initiation of both events, activation of CDK2/cyclin E is thought to link these two events. We identified nucleophosmin ( NPM/ B23) as a substrate of CDK2/cyclin E in centrosome duplication. NPM/ B23 associates specifically with unduplicated centrosomes, and NPM/ B23 dissociates from centrosomes by CDK2/cyclin E-mediated phosphorylation. An anti- NPM/ B23 antibody, which blocks this phosphorylation, suppresses the initiation of centrosome duplication in vivo. Moreover, expression of a nonphosphorylatable mutant NPM/ B23 in cells effectively blocks centrosome duplication. Thus, NPM/ B23 is a target of CDK2/cyclin E in the initiation of centrosome duplication.[1]

References

  1. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Okuda, M., Horn, H.F., Tarapore, P., Tokuyama, Y., Smulian, A.G., Chan, P.K., Knudsen, E.S., Hofmann, I.A., Snyder, J.D., Bove, K.E., Fukasawa, K. Cell (2000) [Pubmed]
 
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