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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cytogenetic and fluorescence in situ hybridization studies in four cases of plasma cell leukemia.

We present a cytogenetic and fluorescence in situ hybridization (FISH) study, using centromeric probes for chromosomes 3, 7, 11, and 18, TP53 gene (17p13), and RB-1 locus (13q14) DNA probes, in four cases of plasma cell leukemia (PCL). Among the four cases, three presented monosomy of the RB-1 locus and one monoallelic deletion of the TP53 gene. The present report shows the usefulness of the FISH technique to detect abnormalities not previously observed by conventional cytogenetics.[1]

References

  1. Cytogenetic and fluorescence in situ hybridization studies in four cases of plasma cell leukemia. Lloveras, E., Solé, F., Espinet, B., Besses, C., Asensio, A., Abella, E., Woessner, S., Florensa, L. Cancer Genet. Cytogenet. (2000) [Pubmed]
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