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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Plasma Cells

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Disease relevance of Plasma Cells


Psychiatry related information on Plasma Cells


High impact information on Plasma Cells

  • IPCs display plasma cell morphology, selectively express Toll-like receptor (TLR)-7 and TLR9, and are specialized in rapidly secreting massive amounts of type 1 interferon following viral stimulation [8].
  • Remarkably, exogenous expression of BCL-6 in a plasma cell line leads, in an MTA3-dependent manner, to repression of plasma cell-specific transcripts, reactivation of the B cell transcriptional program, expression of B lymphocyte cell surface markers, and reprogramming of cell fate [9].
  • We describe a novel gene, Blimp-1 (for B lymphocyte-induced maturation protein), transcripts of which are rapidly induced during the differentiation of B lymphocytes into immunoglobulin secretory cells and whose expression is characteristic of late B and plasma cell lines [10].
  • Thus we conclude that the increased accumulation of immunoglobulin heavy chain mRNA in immunoglobulin-secreting plasma cells is regulated mainly by posttranscriptional processes [11].
  • Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors [12].

Chemical compound and disease context of Plasma Cells


Biological context of Plasma Cells


Anatomical context of Plasma Cells


Associations of Plasma Cells with chemical compounds

  • We had shown previously that the viral glycoprotein (G) synthesized in cells treated with TM is not glycosylated and is not found on the outer surface of the cell plasma membrane [27].
  • Cholesterol is a primary component of the mammalian cell plasma membrane [28].
  • Here, we have studied the effects of chloroquine and ammonium chloride, which raise the pH of acidic intracellular compartments, on the processing and secretion of immunoglobulins by plasma cells [29].
  • Whilst the molecular action of glucagon at the level of the cell plasma membrane in activating adenylate cyclase is relatively well understood, we know little, if anything, of the molecular consequences of insulin occupying its receptor [30].
  • Histamine excess in plasma cell leukemia. A case with unusual clinical manifestations [31].

Gene context of Plasma Cells


Analytical, diagnostic and therapeutic context of Plasma Cells


  1. Accelerated conversion of androgen to estrogen in plasma-cell dyscrasia associated with polyneuropathy, anasarca, and skin pigmentation. Matsumine, H. N. Engl. J. Med. (1985) [Pubmed]
  2. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Tsukada, S., Saffran, D.C., Rawlings, D.J., Parolini, O., Allen, R.C., Klisak, I., Sparkes, R.S., Kubagawa, H., Mohandas, T., Quan, S. Cell (1993) [Pubmed]
  3. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Lin, Y., Wong, K., Calame, K. Science (1997) [Pubmed]
  4. Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes. Bauer, J., Bauer, T.M., Kalb, T., Taga, T., Lengyel, G., Hirano, T., Kishimoto, T., Acs, G., Mayer, L., Gerok, W. J. Exp. Med. (1989) [Pubmed]
  5. Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients. Frei, K., Leist, T.P., Meager, A., Gallo, P., Leppert, D., Zinkernagel, R.M., Fontana, A. J. Exp. Med. (1988) [Pubmed]
  6. Relation between duration of smoking cessation and bronchial inflammation in COPD. Lapperre, T.S., Postma, D.S., Gosman, M.M., Snoeck-Stroband, J.B., ten Hacken, N.H., Hiemstra, P.S., Timens, W., Sterk, P.J., Mauad, T. Thorax (2006) [Pubmed]
  7. The secondary structure of human amyloid deposits as determined by circular dichroism spectroscopy. Cascio, M., Glazer, P.A., Wallace, B.A. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  8. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Liu, Y.J. Annu. Rev. Immunol. (2005) [Pubmed]
  9. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Fujita, N., Jaye, D.L., Geigerman, C., Akyildiz, A., Mooney, M.R., Boss, J.M., Wade, P.A. Cell (2004) [Pubmed]
  10. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Turner, C.A., Mack, D.H., Davis, M.M. Cell (1994) [Pubmed]
  11. During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation. Gerster, T., Picard, D., Schaffner, W. Cell (1986) [Pubmed]
  12. Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors. Piechaczyk, M., Yang, J.Q., Blanchard, J.M., Jeanteur, P., Marcu, K.B. Cell (1985) [Pubmed]
  13. Effect of dose-intensive intravenous melphalan and autologous blood stem-cell transplantation on al amyloidosis-associated renal disease. Dember, L.M., Sanchorawala, V., Seldin, D.C., Wright, D.G., LaValley, M., Berk, J.L., Falk, R.H., Skinner, M. Ann. Intern. Med. (2001) [Pubmed]
  14. Plasma-cell granuloma producing calcitriol and hypercalcemia. Helikson, M.A., Havey, A.D., Zerwekh, J.E., Breslau, N.A., Gardner, D.W. Ann. Intern. Med. (1986) [Pubmed]
  15. Human myeloma in vitro colony growth: interrelationships between drug sensitivity, cell kinetics, and patient survival duration. Durie, B.G., Young, L.A., Salmon, S.E. Blood (1983) [Pubmed]
  16. Interleukin-6-induced inhibition of multiple myeloma cell apoptosis: support for the hypothesis that protection is mediated via inhibition of the JNK/SAPK pathway. Xu, F.H., Sharma, S., Gardner, A., Tu, Y., Raitano, A., Sawyers, C., Lichtenstein, A. Blood (1998) [Pubmed]
  17. Concomitant mobilization of plasma cells and hematopoietic progenitors into peripheral blood of multiple myeloma patients: positive selection and transplantation of enriched CD34+ cells to remove circulating tumor cells. Lemoli, R.M., Fortuna, A., Motta, M.R., Rizzi, S., Giudice, V., Nannetti, A., Martinelli, G., Cavo, M., Amabile, M., Mangianti, S., Fogli, M., Conte, R., Tura, S. Blood (1996) [Pubmed]
  18. Immunoglobulin heavy-chain switching in pre-B leukaemias. Kubagawa, H., Mayumi, M., Crist, W.M., Cooper, M.D. Nature (1983) [Pubmed]
  19. Loss of Pax5 promotes plasma cell differentiation. Nera, K.P., Kohonen, P., Narvi, E., Peippo, A., Mustonen, L., Terho, P., Koskela, K., Buerstedde, J.M., Lassila, O. Immunity (2006) [Pubmed]
  20. Transcriptional regulation of the murine 3' IgH enhancer by OCT-2. Tang, H., Sharp, P.A. Immunity (1999) [Pubmed]
  21. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Kopf, M., Ruedl, C., Schmitz, N., Gallimore, A., Lefrang, K., Ecabert, B., Odermatt, B., Bachmann, M.F. Immunity (1999) [Pubmed]
  22. CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells. Tourigny, M.R., Ursini-Siegel, J., Lee, H., Toellner, K.M., Cunningham, A.F., Franklin, D.S., Ely, S., Chen, M., Qin, X.F., Xiong, Y., MacLennan, I.C., Chen-Kiang, S. Immunity (2002) [Pubmed]
  23. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Delogu, A., Schebesta, A., Sun, Q., Aschenbrenner, K., Perlot, T., Busslinger, M. Immunity (2006) [Pubmed]
  24. BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells. Piskurich, J.F., Lin, K.I., Lin, Y., Wang, Y., Ting, J.P., Calame, K. Nat. Immunol. (2000) [Pubmed]
  25. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. Shapiro-Shelef, M., Lin, K.I., Savitsky, D., Liao, J., Calame, K. J. Exp. Med. (2005) [Pubmed]
  26. Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice. Kearney, J.F., Cooper, M.D., Klein, J., Abney, E.R., Parkhouse, R.M., Lawton, A.R. J. Exp. Med. (1977) [Pubmed]
  27. Synthesis and infectivity of vesicular stomatitis virus containing nonglycosylated G protein. Gibson, R., Leavitt, R., Kornfeld, S., Schlesinger, S. Cell (1978) [Pubmed]
  28. Cholesterol levels inversely reflect the thermal sensitivity of mammalian cells in culture. Cress, A.E., Gerner, E.W. Nature (1980) [Pubmed]
  29. Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion. Thorens, B., Vassalli, P. Nature (1986) [Pubmed]
  30. Insulin trigger, cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase. Marchmont, R.J., Houslay, M.D. Nature (1980) [Pubmed]
  31. Histamine excess in plasma cell leukemia. A case with unusual clinical manifestations. Srichaikul, T., Thithapandha, A., Lochajaya, S., Akarawong, K., Pauvilai, K. JAMA (1975) [Pubmed]
  32. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Jego, G., Palucka, A.K., Blanck, J.P., Chalouni, C., Pascual, V., Banchereau, J. Immunity (2003) [Pubmed]
  33. Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. Taga, T., Kawanishi, Y., Hardy, R.R., Hirano, T., Kishimoto, T. J. Exp. Med. (1987) [Pubmed]
  34. A tumor-associated antigen specific for human kappa myeloma cells. Boux, H.A., Raison, R.L., Walker, K.Z., Hayden, G.E., Basten, A. J. Exp. Med. (1983) [Pubmed]
  35. Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity. Cortés, M., Georgopoulos, K. J. Exp. Med. (2004) [Pubmed]
  36. Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Pearse, R.N., Sordillo, E.M., Yaccoby, S., Wong, B.R., Liau, D.F., Colman, N., Michaeli, J., Epstein, J., Choi, Y. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  37. Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1. Rebbe, N.F., Tong, B.D., Finley, E.M., Hickman, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  38. Phenotypic characterization of the human myeloma cell growth fraction. Robillard, N., Pellat-Deceunynck, C., Bataille, R. Blood (2005) [Pubmed]
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