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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The ALG-2/ AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis.

During the development of an organism cell proliferation, differentiation and cell death are tightly balanced, and are controlled by a number of different regulators. Alterations in this balance are often observed in a variety of human diseases. The role of Ca(2+) as one of the key regulators of the cell is discussed with respect to two recently discovered proteins, ALG-2 and AIP, of which the former is a Ca(2+)-binding protein, and the latter is substrate to various kinases. The two proteins interact with each other in a Ca(2+)-dependent manner, and the role of the complex ALG-2/ AIP as a possible modulator at the interface between cell proliferation and cell death is discussed.[1]


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