The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The evolution of modern lineages of mouse L1 elements.

There are three known families of L1 elements in the Mus genome, V, F, and A. An individual L1 element is classified as a member of one of these families based on which of three different types of transcription promoters is at its 5' end. Initial evidence suggested that the only actively transposing L1 elements in the modern mouse genome were a young subfamily of A-type elements. That belief was overturned when a transposing F subfamily, T(F), was discovered. We used molecular phylogenetic methods to investigate the emergence of the two currently transposing L1 lineages, young A's and T(F)'s. Both of these subfamilies appear to be direct descendants from a specific clade of F-type L1's. Our results imply that recombination between L1 sequences occurred in the lineage from which the T(F) subfamily evolved. We also found that phylogenetic analysis of a L1 3' untranslated region (UTR) is diagnostic for the promoter type at the 5' end of the sequence and, therefore, for the family to which it belongs. As part of this investigation, we developed a set of full-length L1 sequences, which may serve as a general reference set for phylogenetic analyses in Mus. Our analyses included 21 full-length L1 elements from the GenBank nonredundant database that had not been phylogenetically analyzed previously.[1]


  1. The evolution of modern lineages of mouse L1 elements. Mears, M.L., Hutchison, C.A. J. Mol. Evol. (2001) [Pubmed]
WikiGenes - Universities