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Nakopoulou, L. et al.

Nakopoulou, Zervas, Gakiopoulou-Givalou, Constantinides, Doumanis, Davaris, Dimopoulos,

Prognostic value of E-cadherin, beta-catenin, P120ctn in patients with transitional cell bladder cancer.

BACKGROUND: Loss of E-cadherin-catenin mediated adhesion is known to play a major role in tumour progression in many human carcinomas. MATERIALS AND METHODS: By means of immunohistochemistry, we have investigated the expression of E-cadherin, beta-catenin and p120ctn in 102 transitional cell bladder carcinomas (TCCs) and statistically analysed these expressions with known clinicopathological parameters and patient survival. RESULTS: Abnormal expression of E-cadherin, beta-catenin and p120ctn was associated with high grade and high stage of TCCs (p < 0.001). Abnormal beta-catenin expression demonstrated a statistically significant correlation with poor patient survival (p = 0.03) while abnormal E-cadherin expression was associated with poor survival in patients with muscle invasive TCCs (p = 0.025). However, in multivariate statistical analysis a suggestive association with poor survival was observed only for E-cadherin (p = 0.06). Simultaneous abnormal expression of all the molecules demonstrated an association of suggestive significance with poor patient survival (p = 0.07). CONCLUSION: E-cadherin expression may be a useful prognostic marker in patients with invasive TCCs.[1]

References

Prognostic value of E-cadherin, beta-catenin, P120ctn in patients with transitional cell bladder cancer. Nakopoulou, L., Zervas, A., Gakiopoulou-Givalou, H., Constantinides, C., Doumanis, G., Davaris, P., Dimopoulos, C. Anticancer Res. (2000) [Pubmed]

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