Gene Review:
CDH1 - cadherin 1, type 1, E-cadherin (epithelial)
Homo sapiens
Synonyms:
Arc-1, CAM 120/80, CD324, CDHE, Cadherin-1, ...
Chakrabarty,
Varani,
Appelman,
Radjendirane,
Graziano,
More,
Muretto,
Silva,
Arduini,
Testa,
Guilford,
Cascinu,
Humar,
Magnani,
Bearzi,
Ruzzo,
Mari,
Moran,
McAnena,
Joyce,
Ikonen,
Tammela,
Mononen,
Pukkala,
Helin,
Schleutker,
Koivisto,
Tommola,
Hyytinen,
Matikainen,
Kallioniemi,
Kung-Hao Liang,
Jamal,
Schneider,
Gamboa-Dominguez,
Becker,
Busch,
Dominguez-Fonseca,
Chavarri-Guerra,
Reyes-Gutierrez,
Luber,
Becker,
Höfler,
Vargas,
Green,
Fend,
Quintanilla-Martinez,
Al Moustafa,
Alaoui-Jamali,
Yen,
Benlimame,
Chia-Ling Tu,
Wenhan Chang,
Daniel D. Bikle,
Zhongjian Xie,
- Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Suriano, G., Oliveira, C., Ferreira, P., Machado, J.C., Bordin, M.C., De Wever, O., Bruyneel, E.A., Moguilevsky, N., Grehan, N., Porter, T.R., Richards, F.M., Hruban, R.H., Roviello, F., Huntsman, D., Mareel, M., Carneiro, F., Caldas, C., Seruca, R. Hum. Mol. Genet. (2003)
- E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Peña, C., García, J.M., Silva, J., García, V., Rodríguez, R., Alonso, I., Millán, I., Salas, C., de Herreros, A.G., Muñoz, A., Bonilla, F. Hum. Mol. Genet. (2005)
- Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas. Inoue, M., Starostik, P., Zettl, A., Ströbel, P., Schwarz, S., Scaravilli, F., Henry, K., Willcox, N., Müller-Hermelink, H.K., Marx, A. Cancer Res. (2003)
- The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea. Kim, H.C., Wheeler, J.M., Kim, J.C., Ilyas, M., Beck, N.E., Kim, B.S., Park, K.C., Bodmer, W.F. Gut (2000)
- Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Winter, J.M., Ting, A.H., Vilardell, F., Gallmeier, E., Baylin, S.B., Hruban, R.H., Kern, S.E., Iacobuzio-Donahue, C.A. Clin. Cancer Res. (2008)
- A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. Marambaud, P., Shioi, J., Serban, G., Georgakopoulos, A., Sarner, S., Nagy, V., Baki, L., Wen, P., Efthimiopoulos, S., Shao, Z., Wisniewski, T., Robakis, N.K. EMBO J. (2002)
- Patterns of gene promoter methylation in squamous cell cancer of the head and neck. Hasegawa, M., Nelson, H.H., Peters, E., Ringstrom, E., Posner, M., Kelsey, K.T. Oncogene (2002)
- Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Lasorella, A., Stegmüller, J., Guardavaccaro, D., Liu, G., Carro, M.S., Rothschild, G., de la Torre-Ubieta, L., Pagano, M., Bonni, A., Iavarone, A. Nature (2006)
- Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele. Blair, I.P., Chetcuti, A.F., Badenhop, R.F., Scimone, A., Moses, M.J., Adams, L.J., Craddock, N., Green, E., Kirov, G., Owen, M.J., Kwok, J.B., Donald, J.A., Mitchell, P.B., Schofield, P.R. Mol. Psychiatry (2006)
- Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family. Gross, J., Grimm, O., Ortega, G., Teuber, I., Lesch, K.P., Meyer, J. Psychiatr. Genet. (2001)
- p120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho. Wildenberg, G.A., Dohn, M.R., Carnahan, R.H., Davis, M.A., Lobdell, N.A., Settleman, J., Reynolds, A.B. Cell (2006)
- Type II cadherin ectodomain structures: implications for classical cadherin specificity. Patel, S.D., Ciatto, C., Chen, C.P., Bahna, F., Rajebhosale, M., Arkus, N., Schieren, I., Jessell, T.M., Honig, B., Price, S.R., Shapiro, L. Cell (2006)
- Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Ting, A.H., Schuebel, K.E., Herman, J.G., Baylin, S.B. Nat. Genet. (2005)
- Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang, J., Mani, S.A., Donaher, J.L., Ramaswamy, S., Itzykson, R.A., Come, C., Savagner, P., Gitelman, I., Richardson, A., Weinberg, R.A. Cell (2004)
- CDH1 germline mutation in hereditary gastric carcinoma. Wang, H.D., Ren, J., Zhang, L. World J. Gastroenterol. (2004)
- CDH1 associated gastric cancer: a report of a family and review of the literature. Moran, C.J., Joyce, M., McAnena, O.J. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2005)
- Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Chakrabarty, S., Radjendirane, V., Appelman, H., Varani, J. Cancer Res. (2003)
- Immunolocalization of the fodrin, E-cadherin, and beta-catenin adhesion complex in infiltrating ductal carcinoma of the breast-comparison with an in vitro model. Sormunen, R.T., Leong, A.S., Vääräniemi, J.P., Fernando, S.S., Eskelinen, S.M. J. Pathol. (1999)
- Recovery of cellular E-cadherin precedes replenishment of estrogen receptor and estrogen-dependent proliferation of breast cancer cells rescued from a death stimulus. Malaguti, C., Rossini, G.P. J. Cell. Physiol. (2002)
- The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Fang, G., Yu, H., Kirschner, M.W. Genes Dev. (1998)
- E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia. Pereira, P.S., Teixeira, A., Pinho, S., Ferreira, P., Fernandes, J., Oliveira, C., Seruca, R., Suriano, G., Casares, F. Hum. Mol. Genet. (2006)
- Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation. Zhou, Y., Ching, Y.P., Chun, A.C., Jin, D.Y. J. Biol. Chem. (2003)
- Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management. Suriano, G., Yew, S., Ferreira, P., Senz, J., Kaurah, P., Ford, J.M., Longacre, T.A., Norton, J.A., Chun, N., Young, S., Oliveira, M.J., Macgillivray, B., Rao, A., Sears, D., Jackson, C.E., Boyd, J., Yee, C., Deters, C., Pai, G.S., Hammond, L.S., McGivern, B.J., Medgyesy, D., Sartz, D., Arun, B., Oelschlager, B.K., Upton, M.P., Neufeld-Kaiser, W., Silva, O.E., Donenberg, T.R., Kooby, D.A., Sharma, S., Jonsson, B.A., Gronberg, H., Gallinger, S., Seruca, R., Lynch, H., Huntsman, D.G. Clin. Cancer Res. (2005)
- E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Lombaerts, M., van Wezel, T., Philippo, K., Dierssen, J.W., Zimmerman, R.M., Oosting, J., van Eijk, R., Eilers, P.H., van de Water, B., Cornelisse, C.J., Cleton-Jansen, A.M. Br. J. Cancer (2006)
- Infiltrating leukocytes confound the detection of E-cadherin promoter methylation in tumors. Lombaerts, M., Middeldorp, J.W., van der Weide, E., Philippo, K., van Wezel, T., Smit, V.T., Cornelisse, C.J., Cleton-Jansen, A.M. Biochem. Biophys. Res. Commun. (2004)
- Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Georgakopoulos, A., Marambaud, P., Efthimiopoulos, S., Shioi, J., Cui, W., Li, H.C., Schütte, M., Gordon, R., Holstein, G.R., Martinelli, G., Mehta, P., Friedrich, V.L., Robakis, N.K. Mol. Cell (1999)
- beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. Tao, Y.S., Edwards, R.A., Tubb, B., Wang, S., Bryan, J., McCrea, P.D. J. Cell Biol. (1996)
- WNT7a induces E-cadherin in lung cancer cells. Ohira, T., Gemmill, R.M., Ferguson, K., Kusy, S., Roche, J., Brambilla, E., Zeng, C., Baron, A., Bemis, L., Erickson, P., Wilder, E., Rustgi, A., Kitajewski, J., Gabrielson, E., Bremnes, R., Franklin, W., Drabkin, H.A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The fate of E- and P-cadherin during the early stages of apoptosis. Schmeiser, K., Grand, R.J. Cell Death Differ. (1999)
- APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase. Floyd, S., Pines, J., Lindon, C. Curr. Biol. (2008)
- Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. Tu, C.L., Chang, W., Xie, Z., Bikle, D.D. J. Biol. Chem. (2008)
- A core function for p120-catenin in cadherin turnover. Davis, M.A., Ireton, R.C., Reynolds, A.B. J. Cell Biol. (2003)
- Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Playford, M.P., Bicknell, D., Bodmer, W.F., Macaulay, V.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Regulation of E-cadherin/catenin complex patterns by epidermal growth factor receptor modulation in human lung cancer cells. Al Moustafa, A.E., Yen, L., Benlimame, N., Alaoui-Jamali, M.A. Lung Cancer (2002)
- E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. Gottardi, C.J., Wong, E., Gumbiner, B.M. J. Cell Biol. (2001)
- Sequential changes in cadherin-catenin expression associated with the progression and heterogeneity of primary oesophageal squamous carcinoma. Sanders, D.S., Bruton, R., Darnton, S.J., Casson, A.G., Hanson, I., Williams, H.K., Jankowski, J. Int. J. Cancer (1998)
- Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer: potential prognostic implication. Shimamoto, T., Ohyashiki, J.H., Hirano, T., Kato, H., Ohyashiki, K. Oncol. Rep. (2004)
- E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer. Jaggi, M., Rao, P.S., Smith, D.J., Wheelock, M.J., Johnson, K.R., Hemstreet, G.P., Balaji, K.C. Cancer Res. (2005)
- Shigella flexneri regulates tight junction-associated proteins in human intestinal epithelial cells. Sakaguchi, T., Köhler, H., Gu, X., McCormick, B.A., Reinecker, H.C. Cell. Microbiol. (2002)
- Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. Bharti, S., Handrow-Metzmacher, H., Zickenheiner, S., Zeitvogel, A., Baumann, R., Starzinski-Powitz, A. Mol. Biol. Cell (2004)
- Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. Laprise, P., Viel, A., Rivard, N. J. Biol. Chem. (2004)
- Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry. Yoon, M., Spear, P.G. J. Virol. (2002)
- Snail and slug play distinct roles during breast carcinoma progression. C??me, C., Magnino, F., Bibeau, F., De Santa Barbara, P., Becker, K.F., Theillet, C., Savagner, P. Clin. Cancer Res. (2006)
- UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells. Jamal, S., Schneider, R.J. J. Clin. Invest. (2002)
- The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Decary, S., Decesse, J.T., Ogryzko, V., Reed, J.C., Naguibneva, I., Harel-Bellan, A., Cremisi, C.E. Mol. Cell. Biol. (2002)
- Beta-catenin mutations in biliary tract cancers: a population-based study in China. Rashid, A., Gao, Y.T., Bhakta, S., Shen, M.C., Wang, B.S., Deng, J., Fraumeni, J.F., Hsing, A.W. Cancer Res. (2001)
- Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Yang, A.D., Camp, E.R., Fan, F., Shen, L., Gray, M.J., Liu, W., Somcio, R., Bauer, T.W., Wu, Y., Hicklin, D.J., Ellis, L.M. Cancer Res. (2006)
- IQGAP1: a key regulator of adhesion and migration. Noritake, J., Watanabe, T., Sato, K., Wang, S., Kaibuchi, K. J. Cell. Sci. (2005)
- E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions. Perrais, M., Chen, X., Perez-Moreno, M., Gumbiner, B.M. Mol. Biol. Cell (2007)
- Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans. Schwartzkopff, S., Gründemann, C., Schweier, O., Rosshart, S., Karjalainen, K.E., Becker, K.F., Pircher, H. J. Immunol. (2007)
- A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs
WikiGenes . Publication - Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex. Eklof Spink, K., Fridman, S.G., Weis, W.I. EMBO J. (2001)
- Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. Fournier, A.K., Campbell, L.E., Castagnino, P., Liu, W.F., Chung, B.M., Weaver, V.M., Chen, C.S., Assoian, R.K. J. Cell. Sci. (2008)
- CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype. Oliveira, M.J., Costa, A.M., Costa, A.C., Ferreira, R.M., Sampaio, P., Machado, J.C., Seruca, R., Mareel, M., Figueiredo, C. J. Infect. Dis. (2009)
- Association of E-cadherin germ-line alterations with prostate cancer. Ikonen, T., Matikainen, M., Mononen, N., Hyytinen, E.R., Helin, H.J., Tommola, S., Tammela, T.L., Pukkala, E., Schleutker, J., Kallioniemi, O.P., Koivisto, P.A. Clin. Cancer Res. (2001)
- Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. Graziano, F., Arduini, F., Ruzzo, A., Bearzi, I., Humar, B., More, H., Silva, R., Muretto, P., Guilford, P., Testa, E., Mari, D., Magnani, M., Cascinu, S. Clin. Cancer Res. (2004)
- CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer. Pharoah, P.D., Oliveira, C., Machado, J.C., Keller, G., Vogelsang, H., Laux, H., Becker, K.F., Hahn, H., Paproski, S.M., Brown, L.A., Caldas, C., Huntsman, D. Int. J. Cancer (2002)
- E-cadherin expression in sporadic gastric cancer from Mexico: exon 8 and 9 deletions are infrequent events associated with poor survival. Gamboa-Dominguez, A., Dominguez-Fonseca, C., Chavarri-Guerra, Y., Vargas, R., Reyes-Gutierrez, E., Green, D., Quintanilla-Martinez, L., Luber, B., Busch, R., Becker, K.F., Becker, I., Höfler, H., Fend, F. Hum. Pathol. (2005)