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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Requirement for the SLP-76 adaptor GADS in T cell development.

GADS is an adaptor protein implicated in CD3 signaling because of its ability to link SLP-76 to LAT. A GADS-deficient mouse was generated by gene targeting, and the function of GADS in T cell development and activation was examined. GADS- CD4-CD8- thymocytes exhibited a severe block in proliferation but still differentiated into mature T cells. GADS- thymocytes failed to respond to CD3 cross-linking in vivo and were impaired in positive and negative selection. Immunoprecipitation experiments revealed that the association between SLP-76 and LAT was uncoupled in GADS- thymocytes. These observations indicate that GADS is a critical adaptor for CD3 signaling.[1]


  1. Requirement for the SLP-76 adaptor GADS in T cell development. Yoder, J., Pham, C., Iizuka, Y.M., Kanagawa, O., Liu, S.K., McGlade, J., Cheng, A.M. Science (2001) [Pubmed]
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