The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Targeting

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gene Targeting


Psychiatry related information on Gene Targeting


High impact information on Gene Targeting

  • Genetic analysis of the role of these tyrosine kinases has been facilitated by recent advance in transgenic and gene targeting technology as well as by the identification of the genetic basis of several human and murine immune deficiencies [7].
  • Heterogeneity of disease in the mouse models is due to the variety of gene-targeting strategies used in the generation of the CF mouse models as well as the diversity of the murine genetic background [8].
  • To understand the biological properties of GATA1s and its relation to DS-AMKL and TMD, we used gene targeting to generate Gata1 alleles that express GATA1s in mice [9].
  • Therefore, we used a tissue-specific inducible gene-targeting approach to study the physiological role of the Notch1 receptor in the mouse epidermis and the corneal epithelium of adult mice [10].
  • We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks [11].

Chemical compound and disease context of Gene Targeting


Biological context of Gene Targeting


Anatomical context of Gene Targeting


Associations of Gene Targeting with chemical compounds


Gene context of Gene Targeting


Analytical, diagnostic and therapeutic context of Gene Targeting


  1. Interleukin-10-deficient mice develop chronic enterocolitis. Kühn, R., Löhler, J., Rennick, D., Rajewsky, K., Müller, W. Cell (1993) [Pubmed]
  2. Atm-deficient mice: a paradigm of ataxia telangiectasia. Barlow, C., Hirotsune, S., Paylor, R., Liyanage, M., Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J.N., Ried, T., Tagle, D., Wynshaw-Boris, A. Cell (1996) [Pubmed]
  3. The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]. Penninger, J.M., Neu, N., Timms, E., Wallace, V.A., Koh, D.R., Kishihara, K., Pummerer, C., Mak, T.W. J. Exp. Med. (1993) [Pubmed]
  4. Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. Braaten, D., Luban, J. EMBO J. (2001) [Pubmed]
  5. Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates. Sonoda, E., Okada, T., Zhao, G.Y., Tateishi, S., Araki, K., Yamaizumi, M., Yagi, T., Verkaik, N.S., van Gent, D.C., Takata, M., Takeda, S. EMBO J. (2003) [Pubmed]
  6. Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice. Siems, W., Maul, B., Krause, W., Gerard, C., Hauser, K.F., Hersh, L.B., Fischer, H.S., Zernig, G., Saria, A. Eur. J. Pharmacol. (2000) [Pubmed]
  7. Genetic analysis of tyrosine kinase function in B cell development. Satterthwaite, A., Witte, O. Annu. Rev. Immunol. (1996) [Pubmed]
  8. Pathophysiology of gene-targeted mouse models for cystic fibrosis. Grubb, B.R., Boucher, R.C. Physiol. Rev. (1999) [Pubmed]
  9. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Li, Z., Godinho, F.J., Klusmann, J.H., Garriga-Canut, M., Yu, C., Orkin, S.H. Nat. Genet. (2005) [Pubmed]
  10. Notch1 functions as a tumor suppressor in mouse skin. Nicolas, M., Wolfer, A., Raj, K., Kummer, J.A., Mill, P., van Noort, M., Hui, C.C., Clevers, H., Dotto, G.P., Radtke, F. Nat. Genet. (2003) [Pubmed]
  11. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Bassing, C.H., Suh, H., Ferguson, D.O., Chua, K.F., Manis, J., Eckersdorff, M., Gleason, M., Bronson, R., Lee, C., Alt, F.W. Cell (2003) [Pubmed]
  12. Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. Koller, B.H., Kim, H.S., Latour, A.M., Brigman, K., Boucher, R.C., Scambler, P., Wainwright, B., Smithies, O. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  13. Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2). Su, Z.Z., Leszczyniecka, M., Kang, D.C., Sarkar, D., Chao, W., Volsky, D.J., Fisher, P.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  14. In vitro targeting and specific transfection of human neuroblastoma cells by chCE7 antibody-mediated gene transfer. Coll, J.L., Wagner, E., Combaret, V., Metchler, K., Amstutz, H., Iacono-Di-Cacito, I., Simon, N., Favrot, M.C. Gene Ther. (1997) [Pubmed]
  15. Generation of a mouse with low galactocerebrosidase activity by gene targeting: a new model of globoid cell leukodystrophy (Krabbe disease). Luzi, P., Rafi, M.A., Zaka, M., Curtis, M., Vanier, M.T., Wenger, D.A. Mol. Genet. Metab. (2001) [Pubmed]
  16. Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Ichihara, S., Senbonmatsu, T., Price, E., Ichiki, T., Gaffney, F.A., Inagami, T. Circulation (2001) [Pubmed]
  17. Genomic instability in Gadd45a-deficient mice. Hollander, M.C., Sheikh, M.S., Bulavin, D.V., Lundgren, K., Augeri-Henmueller, L., Shehee, R., Molinaro, T.A., Kim, K.E., Tolosa, E., Ashwell, J.D., Rosenberg, M.P., Zhan, Q., Fernández-Salguero, P.M., Morgan, W.F., Deng, C.X., Fornace, A.J. Nat. Genet. (1999) [Pubmed]
  18. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Kemp, C.J., Donehower, L.A., Bradley, A., Balmain, A. Cell (1993) [Pubmed]
  19. The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. Tate, P., Skarnes, W., Bird, A. Nat. Genet. (1996) [Pubmed]
  20. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E., Yuan, J. Cell (1998) [Pubmed]
  21. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D.Y., Nakayama, K. Cell (1996) [Pubmed]
  22. A map of pheromone receptor activation in the mammalian brain. Belluscio, L., Koentges, G., Axel, R., Dulac, C. Cell (1999) [Pubmed]
  23. Thymocyte apoptosis induced by p53-dependent and independent pathways. Clarke, A.R., Purdie, C.A., Harrison, D.J., Morris, R.G., Bird, C.C., Hooper, M.L., Wyllie, A.H. Nature (1993) [Pubmed]
  24. Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Escary, J.L., Perreau, J., Duménil, D., Ezine, S., Brûlet, P. Nature (1993) [Pubmed]
  25. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Pasparakis, M., Courtois, G., Hafner, M., Schmidt-Supprian, M., Nenci, A., Toksoy, A., Krampert, M., Goebeler, M., Gillitzer, R., Israel, A., Krieg, T., Rajewsky, K., Haase, I. Nature (2002) [Pubmed]
  26. Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Xu, M., Hu, X.T., Cooper, D.C., Moratalla, R., Graybiel, A.M., White, F.J., Tonegawa, S. Cell (1994) [Pubmed]
  27. Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Li, Y., Erzurumlu, R.S., Chen, C., Jhaveri, S., Tonegawa, S. Cell (1994) [Pubmed]
  28. Mice lacking ornithine-delta-aminotransferase have paradoxical neonatal hypoornithinaemia and retinal degeneration. Wang, T., Lawler, A.M., Steel, G., Sipila, I., Milam, A.H., Valle, D. Nat. Genet. (1995) [Pubmed]
  29. Severe impairment of spermatogenesis in mice lacking the CREM gene. Blendy, J.A., Kaestner, K.H., Weinbauer, G.F., Nieschlag, E., Schütz, G. Nature (1996) [Pubmed]
  30. Noradrenaline is essential for mouse fetal development. Thomas, S.A., Matsumoto, A.M., Palmiter, R.D. Nature (1995) [Pubmed]
  31. Pax6 is required for the multipotent state of retinal progenitor cells. Marquardt, T., Ashery-Padan, R., Andrejewski, N., Scardigli, R., Guillemot, F., Gruss, P. Cell (2001) [Pubmed]
  32. Features of systemic lupus erythematosus in Dnase1-deficient mice. Napirei, M., Karsunky, H., Zevnik, B., Stephan, H., Mannherz, H.G., Möröy, T. Nat. Genet. (2000) [Pubmed]
  33. Control of neurulation by the nucleosome assembly protein-1-like 2. Rogner, U.C., Spyropoulos, D.D., Le Novère, N., Changeux, J.P., Avner, P. Nat. Genet. (2000) [Pubmed]
  34. Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Edelmann, W., Yang, K., Umar, A., Heyer, J., Lau, K., Fan, K., Liedtke, W., Cohen, P.E., Kane, M.F., Lipford, J.R., Yu, N., Crouse, G.F., Pollard, J.W., Kunkel, T., Lipkin, M., Kolodner, R., Kucherlapati, R. Cell (1997) [Pubmed]
  35. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Bain, G., Maandag, E.C., Izon, D.J., Amsen, D., Kruisbeek, A.M., Weintraub, B.C., Krop, I., Schlissel, M.S., Feeney, A.J., van Roon, M. Cell (1994) [Pubmed]
  36. A common human beta globin splicing mutation modeled in mice. Lewis, J., Yang, B., Kim, R., Sierakowska, H., Kole, R., Smithies, O., Maeda, N. Blood (1998) [Pubmed]
  37. Extrachromosomal genes: a powerful tool in gene targeting approaches. Colosimo, A., Guida, V., Palka, G., Dallapiccola, B. Gene Ther. (2002) [Pubmed]
  38. Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute virus of mice. Hendrie, P.C., Hirata, R.K., Russell, D.W. J. Virol. (2003) [Pubmed]
  39. Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens. Salmivirta, K., Talts, J.F., Olsson, M., Sasaki, T., Timpl, R., Ekblom, P. Exp. Cell Res. (2002) [Pubmed]
  40. New findings in pharmacological effects induced by antihistamines: from PET studies to knock-out mice. Yanai, K., Okamura, N., Tagawa, M., Itoh, M., Watanabe, T. Clin. Exp. Allergy (1999) [Pubmed]
WikiGenes - Universities