MeSH Review:
Gene Targeting
- Interleukin-10-deficient mice develop chronic enterocolitis. Kühn, R., Löhler, J., Rennick, D., Rajewsky, K., Müller, W. Cell (1993)
- Atm-deficient mice: a paradigm of ataxia telangiectasia. Barlow, C., Hirotsune, S., Paylor, R., Liyanage, M., Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J.N., Ried, T., Tagle, D., Wynshaw-Boris, A. Cell (1996)
- The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]. Penninger, J.M., Neu, N., Timms, E., Wallace, V.A., Koh, D.R., Kishihara, K., Pummerer, C., Mak, T.W. J. Exp. Med. (1993)
- Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. Braaten, D., Luban, J. EMBO J. (2001)
- Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates. Sonoda, E., Okada, T., Zhao, G.Y., Tateishi, S., Araki, K., Yamaizumi, M., Yagi, T., Verkaik, N.S., van Gent, D.C., Takata, M., Takeda, S. EMBO J. (2003)
- Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice. Siems, W., Maul, B., Krause, W., Gerard, C., Hauser, K.F., Hersh, L.B., Fischer, H.S., Zernig, G., Saria, A. Eur. J. Pharmacol. (2000)
- Genetic analysis of tyrosine kinase function in B cell development. Satterthwaite, A., Witte, O. Annu. Rev. Immunol. (1996)
- Pathophysiology of gene-targeted mouse models for cystic fibrosis. Grubb, B.R., Boucher, R.C. Physiol. Rev. (1999)
- Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Li, Z., Godinho, F.J., Klusmann, J.H., Garriga-Canut, M., Yu, C., Orkin, S.H. Nat. Genet. (2005)
- Notch1 functions as a tumor suppressor in mouse skin. Nicolas, M., Wolfer, A., Raj, K., Kummer, J.A., Mill, P., van Noort, M., Hui, C.C., Clevers, H., Dotto, G.P., Radtke, F. Nat. Genet. (2003)
- Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Bassing, C.H., Suh, H., Ferguson, D.O., Chua, K.F., Manis, J., Eckersdorff, M., Gleason, M., Bronson, R., Lee, C., Alt, F.W. Cell (2003)
- Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. Koller, B.H., Kim, H.S., Latour, A.M., Brigman, K., Boucher, R.C., Scambler, P., Wainwright, B., Smithies, O. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2). Su, Z.Z., Leszczyniecka, M., Kang, D.C., Sarkar, D., Chao, W., Volsky, D.J., Fisher, P.B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- In vitro targeting and specific transfection of human neuroblastoma cells by chCE7 antibody-mediated gene transfer. Coll, J.L., Wagner, E., Combaret, V., Metchler, K., Amstutz, H., Iacono-Di-Cacito, I., Simon, N., Favrot, M.C. Gene Ther. (1997)
- Generation of a mouse with low galactocerebrosidase activity by gene targeting: a new model of globoid cell leukodystrophy (Krabbe disease). Luzi, P., Rafi, M.A., Zaka, M., Curtis, M., Vanier, M.T., Wenger, D.A. Mol. Genet. Metab. (2001)
- Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Ichihara, S., Senbonmatsu, T., Price, E., Ichiki, T., Gaffney, F.A., Inagami, T. Circulation (2001)
- Genomic instability in Gadd45a-deficient mice. Hollander, M.C., Sheikh, M.S., Bulavin, D.V., Lundgren, K., Augeri-Henmueller, L., Shehee, R., Molinaro, T.A., Kim, K.E., Tolosa, E., Ashwell, J.D., Rosenberg, M.P., Zhan, Q., Fernández-Salguero, P.M., Morgan, W.F., Deng, C.X., Fornace, A.J. Nat. Genet. (1999)
- Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Kemp, C.J., Donehower, L.A., Bradley, A., Balmain, A. Cell (1993)
- The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. Tate, P., Skarnes, W., Bird, A. Nat. Genet. (1996)
- Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E., Yuan, J. Cell (1998)
- Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D.Y., Nakayama, K. Cell (1996)
- A map of pheromone receptor activation in the mammalian brain. Belluscio, L., Koentges, G., Axel, R., Dulac, C. Cell (1999)
- Thymocyte apoptosis induced by p53-dependent and independent pathways. Clarke, A.R., Purdie, C.A., Harrison, D.J., Morris, R.G., Bird, C.C., Hooper, M.L., Wyllie, A.H. Nature (1993)
- Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Escary, J.L., Perreau, J., Duménil, D., Ezine, S., Brûlet, P. Nature (1993)
- TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Pasparakis, M., Courtois, G., Hafner, M., Schmidt-Supprian, M., Nenci, A., Toksoy, A., Krampert, M., Goebeler, M., Gillitzer, R., Israel, A., Krieg, T., Rajewsky, K., Haase, I. Nature (2002)
- Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Xu, M., Hu, X.T., Cooper, D.C., Moratalla, R., Graybiel, A.M., White, F.J., Tonegawa, S. Cell (1994)
- Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Li, Y., Erzurumlu, R.S., Chen, C., Jhaveri, S., Tonegawa, S. Cell (1994)
- Mice lacking ornithine-delta-aminotransferase have paradoxical neonatal hypoornithinaemia and retinal degeneration. Wang, T., Lawler, A.M., Steel, G., Sipila, I., Milam, A.H., Valle, D. Nat. Genet. (1995)
- Severe impairment of spermatogenesis in mice lacking the CREM gene. Blendy, J.A., Kaestner, K.H., Weinbauer, G.F., Nieschlag, E., Schütz, G. Nature (1996)
- Noradrenaline is essential for mouse fetal development. Thomas, S.A., Matsumoto, A.M., Palmiter, R.D. Nature (1995)
- Pax6 is required for the multipotent state of retinal progenitor cells. Marquardt, T., Ashery-Padan, R., Andrejewski, N., Scardigli, R., Guillemot, F., Gruss, P. Cell (2001)
- Features of systemic lupus erythematosus in Dnase1-deficient mice. Napirei, M., Karsunky, H., Zevnik, B., Stephan, H., Mannherz, H.G., Möröy, T. Nat. Genet. (2000)
- Control of neurulation by the nucleosome assembly protein-1-like 2. Rogner, U.C., Spyropoulos, D.D., Le Novère, N., Changeux, J.P., Avner, P. Nat. Genet. (2000)
- Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Edelmann, W., Yang, K., Umar, A., Heyer, J., Lau, K., Fan, K., Liedtke, W., Cohen, P.E., Kane, M.F., Lipford, J.R., Yu, N., Crouse, G.F., Pollard, J.W., Kunkel, T., Lipkin, M., Kolodner, R., Kucherlapati, R. Cell (1997)
- E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Bain, G., Maandag, E.C., Izon, D.J., Amsen, D., Kruisbeek, A.M., Weintraub, B.C., Krop, I., Schlissel, M.S., Feeney, A.J., van Roon, M. Cell (1994)
- A common human beta globin splicing mutation modeled in mice. Lewis, J., Yang, B., Kim, R., Sierakowska, H., Kole, R., Smithies, O., Maeda, N. Blood (1998)
- Extrachromosomal genes: a powerful tool in gene targeting approaches. Colosimo, A., Guida, V., Palka, G., Dallapiccola, B. Gene Ther. (2002)
- Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute virus of mice. Hendrie, P.C., Hirata, R.K., Russell, D.W. J. Virol. (2003)
- Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens. Salmivirta, K., Talts, J.F., Olsson, M., Sasaki, T., Timpl, R., Ekblom, P. Exp. Cell Res. (2002)
- New findings in pharmacological effects induced by antihistamines: from PET studies to knock-out mice. Yanai, K., Okamura, N., Tagawa, M., Itoh, M., Watanabe, T. Clin. Exp. Allergy (1999)