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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Gene Targeting

 
 
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Disease relevance of Gene Targeting

 

Psychiatry related information on Gene Targeting

 

High impact information on Gene Targeting

  • Genetic analysis of the role of these tyrosine kinases has been facilitated by recent advance in transgenic and gene targeting technology as well as by the identification of the genetic basis of several human and murine immune deficiencies [7].
  • Heterogeneity of disease in the mouse models is due to the variety of gene-targeting strategies used in the generation of the CF mouse models as well as the diversity of the murine genetic background [8].
  • To understand the biological properties of GATA1s and its relation to DS-AMKL and TMD, we used gene targeting to generate Gata1 alleles that express GATA1s in mice [9].
  • Therefore, we used a tissue-specific inducible gene-targeting approach to study the physiological role of the Notch1 receptor in the mouse epidermis and the corneal epithelium of adult mice [10].
  • We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks [11].
 

Chemical compound and disease context of Gene Targeting

 

Biological context of Gene Targeting

 

Anatomical context of Gene Targeting

 

Associations of Gene Targeting with chemical compounds

 

Gene context of Gene Targeting

 

Analytical, diagnostic and therapeutic context of Gene Targeting

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