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Gene Review

Grap2  -  GRB2-related adaptor protein 2

Mus musculus

Synonyms: Adapter protein GRID, GADS protein, GRAP-2, GRB-2-like protein, GRB-2-related monocytic adapter protein, ...
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Disease relevance of Grap2

  • Splenic immune suppression in sepsis: A role for IL-10-induced changes in P38 MAPK signaling [1].

High impact information on Grap2

  • Requirement for the SLP-76 adaptor GADS in T cell development [2].
  • A GADS-deficient mouse was generated by gene targeting, and the function of GADS in T cell development and activation was examined [2].
  • After phosphorylation of the cytosolic domain of LAT, multiple signaling molecules such as phospholipase C-gamma1, Grb2, and Gads associate with phosphorylated LAT via their SH2 domains [3].
  • Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region [4].
  • We further demonstrated that the expression of the Gads-binding region of SLP-76 in bone marrow-derived mast cells inhibits FcepsilonRI-induced calcium flux, degranulation, and cytokine secretion [5].

Biological context of Grap2

  • Regulation of BLNK recruitment was dependent upon the Grap2 proline-rich domain, while modulation of phosphorylation was dependent upon both the proline-rich and SH2 domains [6].
  • The intracellular signaling pathways that regulate homeostasis in CD4(+) and CD8(+) T cells are clearly different, and the Gads adaptor protein is critical for homeostasis of CD4(+) T cells [7].
  • Mapping experiments have revealed that the carboxyl-terminal SH3 domain of Gads and the fourth proline-rich region of HPK1 are essential for their interaction [8].
  • Gads(-/-) CD4(+) T cells were markedly deficient in the spleen and had an activated phenotype and a rapid turnover rate [7].
  • Gads(-/-) CD4(+) T cells, but not CD8(+) T cells, had a severe block of TCR-mediated proliferation and a high rate of spontaneous cell death and were highly susceptible to CD95-induced apoptosis [7].

Anatomical context of Grap2


Associations of Grap2 with chemical compounds


Regulatory relationships of Grap2


Other interactions of Grap2


Analytical, diagnostic and therapeutic context of Grap2


  1. Splenic immune suppression in sepsis: A role for IL-10-induced changes in P38 MAPK signaling. Song, G.Y., Chung, C.S., Schwacha, M.G., Jarrar, D., Chaudry, I.H., Ayala, A. J. Surg. Res. (1999) [Pubmed]
  2. Requirement for the SLP-76 adaptor GADS in T cell development. Yoder, J., Pham, C., Iizuka, Y.M., Kanagawa, O., Liu, S.K., McGlade, J., Cheng, A.M. Science (2001) [Pubmed]
  3. The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. Saitoh, S., Odom, S., Gomez, G., Sommers, C.L., Young, H.A., Rivera, J., Samelson, L.E. J. Exp. Med. (2003) [Pubmed]
  4. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. Law, C.L., Ewings, M.K., Chaudhary, P.M., Solow, S.A., Yun, T.J., Marshall, A.J., Hood, L., Clark, E.A. J. Exp. Med. (1999) [Pubmed]
  5. Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Silverman, M.A., Shoag, J., Wu, J., Koretzky, G.A. Mol. Cell. Biol. (2006) [Pubmed]
  6. Spi-1 and Spi-B control the expression of the Grap2 gene in B cells. Garrett-Sinha, L.A., Hou, P., Wang, D., Grabiner, B., Araujo, E., Rao, S., Yun, T.J., Clark, E.A., Simon, M.C., Clark, M.R. Gene (2005) [Pubmed]
  7. The Gads (GrpL) adaptor protein regulates T cell homeostasis. Yankee, T.M., Yun, T.J., Draves, K.E., Ganesh, K., Bevan, M.J., Murali-Krishna, K., Clark, E.A. J. Immunol. (2004) [Pubmed]
  8. The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR. Liu, S.K., Smith, C.A., Arnold, R., Kiefer, F., McGlade, C.J. J. Immunol. (2000) [Pubmed]
  9. Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. Chen, L.W., Huang, H.L., Lee, I.T., Hsu, C.M., Lu, P.J. Shock (2006) [Pubmed]
  10. Expression and function of the adaptor protein Gads in murine B cells. Yankee, T.M., Draves, K.E., Clark, E.A. Eur. J. Immunol. (2005) [Pubmed]
  11. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Shen, R., Ouyang, Y.B., Qu, C.K., Alonso, A., Sperzel, L., Mustelin, T., Kaplan, M.H., Feng, G.S. Mol. Cell. Biol. (2002) [Pubmed]
  12. Gefitinib and chemotherapy combination studies in five novel human non small cell lung cancer xenografts. Evidence linking EGFR signaling to gefitinib antitumor response. Judde, J.G., Rebucci, M., Vogt, N., de Cremoux, P., Livartowski, A., Chapelier, A., Tran-Perennou, C., Boye, K., Defrance, R., Poupon, M.F., Bras-Gonçalves, R.A. Int. J. Cancer (2007) [Pubmed]
  13. P38 and activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose. Zayzafoon, M., Botolin, S., McCabe, L.R. J. Biol. Chem. (2002) [Pubmed]
  14. Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action. Deng, Y., Bhattacharya, S., Swamy, O.R., Tandon, R., Wang, Y., Janda, R., Riedel, H. J. Biol. Chem. (2003) [Pubmed]
  15. Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts. Winnay, J.N., Brüning, J.C., Burks, D.J., Kahn, C.R. J. Biol. Chem. (2000) [Pubmed]
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