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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A double ring closing metathesis reaction in the rapid, enantioselective synthesis of NK-1 receptor antagonists.

[structure: see text]. The NK-1 receptor antagonist 1 has been prepared in seven steps from phenylglycine methyl ester. The key steps are a double ring closing metathesis reaction of tetraene 7 to prepare spirocycle 6 and a reductive Heck reaction to introduce the aryl moiety. This latter reaction discriminates the olefins of compound 6 and proceeds in a highly regio- and stereoselective manner.[1]

References

  1. A double ring closing metathesis reaction in the rapid, enantioselective synthesis of NK-1 receptor antagonists. Wallace, D.J., Goodman, J.M., Kennedy, D.J., Davies, A.J., Cowden, C.J., Ashwood, M.S., Cottrell, I.F., Dolling, U.H., Reider, P.J. Org. Lett. (2001) [Pubmed]
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