Gene Review:
TACR1 - tachykinin receptor 1
Homo sapiens
Synonyms:
NK-1 receptor, NK-1R, NK1R, NKIR, SPR, ...
Brylla,
Aust,
Geyer,
Uckermann,
Löffler,
Spanel-Borowski,
Chahl,
Lieb,
Ahlvers,
Dancker,
Strohbusch,
Reincke,
Feige,
Berger,
Riemann,
Voderholzer,
Challet,
Naylor,
Metzger,
MacIntyre,
Turek,
Peyrard-Janvid,
Anthoni,
Onkamo,
Lahermo,
Zucchelli,
Kaminen,
Hannula-Jouppi,
Nopola-Hemmi,
Voutilainen,
Lyytinen,
Kere,
Rameshwar,
Gascón,
Maubach,
Martin,
Smith,
Hewson,
Frankshun,
Harrison,
Seabrook,
Forsgren,
Danielson,
Alfredson,
Pennefather,
Patak,
Ziccone,
Lilley,
Pinto,
Page,
Story,
Grover,
Candenas,
Furmark,
Appel,
Michelgård,
Wahlstedt,
Ahs,
Zancan,
Jacobsson,
Flyckt,
Grohp,
Bergström,
Pich,
Nilsson,
Bani,
Långström,
Fredrikson,
- Substance P (NK1)- and neurokinin A (NK2)-receptor gene expression in inflammatory airway diseases. Bai, T.R., Zhou, D., Weir, T., Walker, B., Hegele, R., Hayashi, S., McKay, K., Bondy, G.P., Fong, T. Am. J. Physiol. (1995)
- Molecular cloning, structural characterization and functional expression of the human substance P receptor. Takeda, Y., Chou, K.B., Takeda, J., Sachais, B.S., Krause, J.E. Biochem. Biophys. Res. Commun. (1991)
- Substance P and substance P receptor histochemistry in human neurodegenerative diseases. Kowall, N.W., Quigley, B.J., Krause, J.E., Lu, F., Kosofsky, B.E., Ferrante, R.J. Regul. Pept. (1993)
- Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Mantyh, C.R., Gates, T.S., Zimmerman, R.P., Welton, M.L., Passaro, E.P., Vigna, S.R., Maggio, J.E., Kruger, L., Mantyh, P.W. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine. Renzi, D., Pellegrini, B., Tonelli, F., Surrenti, C., Calabrò, A. Am. J. Pathol. (2000)
- Fine mapping of the 2p11 dyslexia locus and exclusion of TACR1 as a candidate gene. Peyrard-Janvid, M., Anthoni, H., Onkamo, P., Lahermo, P., Zucchelli, M., Kaminen, N., Hannula-Jouppi, K., Nopola-Hemmi, J., Voutilainen, A., Lyytinen, H., Kere, J. Hum. Genet. (2004)
- An NK1 receptor antagonist affects the circadian regulation of locomotor activity in golden hamsters. Challet, E., Naylor, E., Metzger, J.M., MacIntyre, D.E., Turek, F.W. Brain Res. (1998)
- Mutagenesis and knockout models: NK1 and substance P. Bilkei-Gorzo, A., Zimmer, A. Handbook of experimental pharmacology. (2005)
- Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo. Furmark, T., Appel, L., Michelgård, A., Wahlstedt, K., Ahs, F., Zancan, S., Jacobsson, E., Flyckt, K., Grohp, M., Bergström, M., Pich, E.M., Nilsson, L.G., Bani, M., Långström, B., Fredrikson, M. Biol. Psychiatry (2005)
- Effects of the neuropeptide substance P on sleep, mood, and neuroendocrine measures in healthy young men. Lieb, K., Ahlvers, K., Dancker, K., Strohbusch, S., Reincke, M., Feige, B., Berger, M., Riemann, D., Voderholzer, U. Neuropsychopharmacology (2002)
- Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist. Gether, U., Johansen, T.E., Snider, R.M., Lowe, J.A., Nakanishi, S., Schwartz, T.W. Nature (1993)
- Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Malmberg, A.B., Yaksh, T.L. Science (1992)
- The binding site of NK receptors on HLA-C molecules. Mandelboim, O., Reyburn, H.T., Sheu, E.G., Vales-Gomez, M., Davis, D.M., Pazmany, L., Strominger, J.L. Immunity (1997)
- Tachykinins and neuropsychiatric disorders. Chahl, L.A. Current drug targets. (2006)
- Use of an NK1 receptor antagonist to prevent delayed emesis after cisplatin. Kris, M.G., Radford, J.E., Pizzo, B.A., Inabinet, R., Hesketh, A., Hesketh, P.J. J. Natl. Cancer Inst. (1997)
- The substance P receptor antagonist CP-99,994 reduces acute postoperative pain. Dionne, R.A., Max, M.B., Gordon, S.M., Parada, S., Sang, C., Gracely, R.H., Sethna, N.F., MacLean, D.B. Clin. Pharmacol. Ther. (1998)
- Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat. Fox, A., Eastwood, C., Gentry, C., Manning, D., Urban, L. Pain (1999)
- SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line. Oury-Donat, F., Lefevre, I.A., Thurneyssen, O., Gauthier, T., Bordey, A., Feltz, P., Emonds-Alt, X., Le Fur, G., Soubrie, P. J. Neurochem. (1994)
- Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter. Simeonidis, S., Castagliuolo, I., Pan, A., Liu, J., Wang, C.C., Mykoniatis, A., Pasha, A., Valenick, L., Sougioultzis, S., Zhao, D., Pothoulakis, C. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. Gerard, N.P., Garraway, L.A., Eddy, R.L., Shows, T.B., Iijima, H., Paquet, J.L., Gerard, C. Biochemistry (1991)
- Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro. Warabi, K., Richardson, M.D., Barry, W.T., Yamaguchi, K., Roush, E.D., Nishimura, K., Kwatra, M.M. FEBS Lett. (2002)
- The primary structure and gene organization of human substance P and neuromedin K receptors. Takahashi, K., Tanaka, A., Hara, M., Nakanishi, S. Eur. J. Biochem. (1992)
- The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity. Monastyrskaya, K., Hostettler, A., Buergi, S., Draeger, A. J. Biol. Chem. (2005)
- Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences. Belvisi, M.G., Patacchini, R., Barnes, P.J., Maggi, C.A. Br. J. Pharmacol. (1994)
- Tachykinin peptides affect differently the second messenger pathways after binding to CHO-expressed human NK-1 receptors. Sagan, S., Chassaing, G., Pradier, L., Lavielle, S. J. Pharmacol. Exp. Ther. (1996)
- Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists. Derocq, J.M., Ségui, M., Blazy, C., Emonds-Alt, X., Le Fur, G., Brelire, J.C., Casellas, P. FEBS Lett. (1996)
- Regulation of the stimulant actions of neurokinin a and human hemokinin-1 on the human uterus: a comparison with histamine. Pennefather, J.N., Patak, E., Ziccone, S., Lilley, A., Pinto, F.M., Page, N.M., Story, M.E., Grover, S., Candenas, M.L. Biol. Reprod. (2006)
- Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. Sarau, H.M., Griswold, D.E., Potts, W., Foley, J.J., Schmidt, D.B., Webb, E.F., Martin, L.D., Brawner, M.E., Elshourbagy, N.A., Medhurst, A.D., Giardina, G.A., Hay, D.W. J. Pharmacol. Exp. Ther. (1997)
- The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors. Jensen, C.J., Gerard, N.P., Schwartz, T.W., Gether, U. Mol. Pharmacol. (1994)
- Tachykinins cause inward current through NK1 receptors in bullfrog sensory neurons. Akasu, T., Ishimatsu, M., Yamada, K. Brain Res. (1996)
- Amyloid-beta peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor. Joslin, G., Krause, J.E., Hershey, A.D., Adams, S.P., Fallon, R.J., Perlmutter, D.H. J. Biol. Chem. (1991)
- Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor. Cascieri, M.A., Ber, E., Fong, T.M., Sadowski, S., Bansal, A., Swain, C., Seward, E., Frances, B., Burns, D., Strader, C.D. Mol. Pharmacol. (1992)
- Hematopoietic modulation by the tachykinins. Rameshwar, P., Gascón, P. Acta Haematol. (1997)
- Different susceptibility to neurokinin 1 receptor antagonists of substance P and septide-induced interleukin-6 release from U373 MG human astrocytoma cell line. Palma, C., Goso, C., Manzini, S. Neurosci. Lett. (1994)
- Stimulation of immunoglobulin secretion in human B lymphocytes as a direct effect of high concentrations of IL 2. Ralph, P., Jeong, G., Welte, K., Mertelsmann, R., Rabin, H., Henderson, L.E., Souza, L.M., Boone, T.C., Robb, R.J. J. Immunol. (1984)
- Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. Zhao, D., Kuhnt-Moore, S., Zeng, H., Pan, A., Wu, J.S., Simeonidis, S., Moyer, M.P., Pothoulakis, C. Biochem. J. (2002)
- Coexpression of preprotachykinin A and B transcripts in the bovine corpus luteum and evidence for functional neurokinin receptor activity in luteal endothelial cells and ovarian macrophages. Brylla, E., Aust, G., Geyer, M., Uckermann, O., Löffler, S., Spanel-Borowski, K. Regul. Pept. (2005)
- Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct. Patacchini, R., Barthó, L., De Giorgio, R., Lénárd, L., Stanghellini, V., Barbara, G., Lecci, A., Maggi, C.A. Naunyn Schmiedebergs Arch. Pharmacol. (1999)
- Regulation of neurokinin-1 receptor messenger RNA expression in synovial fibroblasts of patients with rheumatoid arthritis. Akasaka, Y., Abe, K., Sato, T., Inoue, H. Neuropeptides (2005)
- Isolation and characterisation of the human lung NK-1 receptor cDNA. Hopkins, B., Powell, S.J., Danks, P., Briggs, I., Graham, A. Biochem. Biophys. Res. Commun. (1991)
- Vascular NK-1 receptor occurrence in normal and chronic painful Achilles and patellar tendons: studies on chemically unfixed as well as fixed specimens. Forsgren, S., Danielson, P., Alfredson, H. Regul. Pept. (2005)
- Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro. Maubach, K.A., Martin, K., Smith, D.W., Hewson, L., Frankshun, R.A., Harrison, T., Seabrook, G.R. Neuropharmacology (2001)