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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

In vivo measurement of [11C]verapamil kinetics in human tissues.

OBJECTIVE: To evaluate [11C]verapamil kinetics in humans. METHODS: After intravenous injection of [11C]verapamil (370 MBq, specific activity >1,600 GBq/mmol), kinetics were evaluated in five cancer patients using positron emission tomography (PET). RESULTS: One hour after injection, accumulation of [11C] in lungs, heart and tumour was 43.0%, 1.3% and 0.9% of the injected verapamil dose, respectively. Half-lives of [11C]verapamil in these tissues were 46.2 min, 73.8 min and 23.7 min, respectively. CONCLUSIONS: Intravenously administered [11C] was mainly extracted by the lungs. Transport of a [11C]verapamil bolus out of solid tumour tissue is relatively fast.[1]

References

  1. In vivo measurement of [11C]verapamil kinetics in human tissues. Hendrikse, N.H., de Vries, E.G., Franssen, E.J., Vaalburg, W., van der Graaf, W.T. Eur. J. Clin. Pharmacol. (2001) [Pubmed]
 
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