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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Conversion of progesterone-1,2-3-H to 5beta-pregnane-3,20-dione by brain tissue.

The presence of a 5beta-reductase acting to convert progesterone to 5beta-pregnane-3,20-dione is described in the soluble 105,000 x g fraction of a preparation of dog cerebral cortex. The function of this enzymatic activity is obscure but may be important in regulation of sensorium. 5beta-pregnane compounds are potent depressors of the central nervous system.[1]

References

  1. Conversion of progesterone-1,2-3-H to 5beta-pregnane-3,20-dione by brain tissue. Kawahara, F.S., Berman, M.L., Green, O.C. Steroids (1975) [Pubmed]
 
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