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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Echoviruses bind heparan sulfate at the cell surface.

Some echoviruses (EV) that bind decay-accelerating factor ( DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.[1]

References

  1. Echoviruses bind heparan sulfate at the cell surface. Goodfellow, I.G., Sioofy, A.B., Powell, R.M., Evans, D.J. J. Virol. (2001) [Pubmed]
 
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