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Disease relevance of Rhabdomyosarcoma


High impact information on Rhabdomyosarcoma

  • GLI gene and rhabdomyosarcoma [6].
  • Gel shift and transient transfection assays revealed that MyoD in the rhabdomyosarcoma cells was capable of binding DNA but was relatively nonfunctional as a transcriptional activator [7].
  • RD rhabdomyosarcoma cells expressed little VLA-2, did not bind to 35S-labeled virus, and resisted infection until transfected with complementary DNA encoding the alpha 2 subunit of VLA-2 [8].
  • Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells [9].
  • Thus, Twist may play multiple roles in the formation of rhabdomyosarcomas, halting terminal differentiation, inhibiting apoptosis, and interfering with the p53 tumor-suppressor pathway [10].

Chemical compound and disease context of Rhabdomyosarcoma


Biological context of Rhabdomyosarcoma


Anatomical context of Rhabdomyosarcoma


Gene context of Rhabdomyosarcoma


Analytical, diagnostic and therapeutic context of Rhabdomyosarcoma


  1. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Hahn, H., Wojnowski, L., Zimmer, A.M., Hall, J., Miller, G., Zimmer, A. Nat. Med. (1998) [Pubmed]
  2. beta-Adrenergic receptors in pediatric tumors: uncoupled beta 1-adrenergic receptor in Ewing's sarcoma. Whitsett, J.A., Burdsall, J., Workman, L., Hollinger, B., Neely, J. J. Natl. Cancer Inst. (1983) [Pubmed]
  3. Role of plasminogen in matrix breakdown by neoplastic cells. Bogenmann, E., Jones, P.A. J. Natl. Cancer Inst. (1983) [Pubmed]
  4. Expression of the retinoblastoma susceptibility gene in childhood rhabdomyosarcomas. De Chiara, A., T'Ang, A., Triche, T.J. J. Natl. Cancer Inst. (1993) [Pubmed]
  5. Enhancement of pulmonary metastases induced by decreased lung natural killer cell activity. Nolibé, D., Poupon, M.F. J. Natl. Cancer Inst. (1986) [Pubmed]
  6. GLI gene and rhabdomyosarcoma. Myklebost, O. Nat. Med. (1998) [Pubmed]
  7. Deficiency in rhabdomyosarcomas of a factor required for MyoD activity and myogenesis. Tapscott, S.J., Thayer, M.J., Weintraub, H. Science (1993) [Pubmed]
  8. Identification of the integrin VLA-2 as a receptor for echovirus 1. Bergelson, J.M., Shepley, M.P., Chan, B.M., Hemler, M.E., Finberg, R.W. Science (1992) [Pubmed]
  9. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Puri, P.L., Wu, Z., Zhang, P., Wood, L.D., Bhakta, K.S., Han, J., Feramisco, J.R., Karin, M., Wang, J.Y. Genes Dev. (2000) [Pubmed]
  10. Twist is a potential oncogene that inhibits apoptosis. Maestro, R., Dei Tos, A.P., Hamamori, Y., Krasnokutsky, S., Sartorelli, V., Kedes, L., Doglioni, C., Beach, D.H., Hannon, G.J. Genes Dev. (1999) [Pubmed]
  11. Cloning efficiency of cultured human tumor cell lines measured with the use of a Coulter particle counter. Hazelton, B.J., Torrance, P.M., George, S.L., Houghton, P.J. J. Natl. Cancer Inst. (1984) [Pubmed]
  12. Fine structure of dividing cells and of nondividing, differentiating cells of nickel sulfide-induced rhabdomyosarcomas. Bruni, C., Rust, J.N. J. Natl. Cancer Inst. (1975) [Pubmed]
  13. Inhibition of rat natural killer cell function by carcinogenic nickel compounds: preventive action of manganese. Judde, J.G., Breillout, F., Clemenceau, C., Poupon, M.F., Jasmin, C. J. Natl. Cancer Inst. (1987) [Pubmed]
  14. Enhanced cloning efficiency of murine rhabdomyosarcoma cells after chlorozotocin treatment: relationship with enhanced lung metastasis. Pauwels, C., Rebischung, J.L., Jasmin, C., Poupon, M.F. J. Natl. Cancer Inst. (1985) [Pubmed]
  15. Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine. Shumaker, R.C., Robertson, K.A., Hsu, I.C., Allen, J.R. J. Natl. Cancer Inst. (1976) [Pubmed]
  16. RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth. Riuzzi, F., Sorci, G., Donato, R. Am. J. Pathol. (2007) [Pubmed]
  17. N-myc oncogene amplification in rhabdomyosarcoma at release. Garson, J.A., Clayton, J., McIntyre, P., Kemshead, J.T. Lancet (1986) [Pubmed]
  18. Functional interaction between human topoisomerase IIalpha and retinoblastoma protein. Bhat, U.G., Raychaudhuri, P., Beck, W.T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  19. Mechanisms of p53 loss in human sarcomas. Mulligan, L.M., Matlashewski, G.J., Scrable, H.J., Cavenee, W.K. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  20. Tumor necrosis factor (TNF)-induced protein phosphorylation in a human rhabdomyosarcoma cell line is mediated by 60-kD TNF receptors (TR60). Mire-Sluis, A., Meager, A. Blood (1994) [Pubmed]
  21. Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. Wachtel, M., Dettling, M., Koscielniak, E., Stegmaier, S., Treuner, J., Simon-Klingenstein, K., Bühlmann, P., Niggli, F.K., Schäfer, B.W. Cancer Res. (2004) [Pubmed]
  22. Solubilization and degradation of extracellular matrix by various metastatic cell lines derived from a rat rhabdomyosarcoma. Becker, M., Moczar, M., Poupon, M.F., Moczar, E. J. Natl. Cancer Inst. (1986) [Pubmed]
  23. The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx. Hollenbach, A.D., Sublett, J.E., McPherson, C.J., Grosveld, G. EMBO J. (1999) [Pubmed]
  24. Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors. Lagutina, I., Conway, S.J., Sublett, J., Grosveld, G.C. Mol. Cell. Biol. (2002) [Pubmed]
  25. Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors. Mechtersheimer, G., Staudter, M., Möller, P. Cancer Res. (1991) [Pubmed]
  26. Immunological prevention of a multigene cancer syndrome. Croci, S., Nicoletti, G., Landuzzi, L., De Giovanni, C., Astolfi, A., Marini, C., Di Carlo, E., Musiani, P., Forni, G., Nanni, P., Lollini, P.L. Cancer Res. (2004) [Pubmed]
  27. Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11. Scrable, H.J., Johnson, D.K., Rinchik, E.M., Cavenee, W.K. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  28. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Libura, J., Drukala, J., Majka, M., Tomescu, O., Navenot, J.M., Kucia, M., Marquez, L., Peiper, S.C., Barr, F.G., Janowska-Wieczorek, A., Ratajczak, M.Z. Blood (2002) [Pubmed]
  29. Loss of imprinting in hepatoblastoma. Rainier, S., Dobry, C.J., Feinberg, A.P. Cancer Res. (1995) [Pubmed]
  30. Inhibition of connective tissue growth factor (CTGF/CCN2) expression decreases the survival and myogenic differentiation of human rhabdomyosarcoma cells. Croci, S., Landuzzi, L., Astolfi, A., Nicoletti, G., Rosolen, A., Sartori, F., Follo, M.Y., Oliver, N., De Giovanni, C., Nanni, P., Lollini, P.L. Cancer Res. (2004) [Pubmed]
  31. Insulin-like growth factor II and PAX3-FKHR cooperate in the oncogenesis of rhabdomyosarcoma. Wang, W., Kumar, P., Wang, W., Epstein, J., Helman, L., Moore, J.V., Kumar, S. Cancer Res. (1998) [Pubmed]
  32. Paratesticular rhabdomyosarcoma: report from the Italian and German Cooperative Group. Ferrari, A., Bisogno, G., Casanova, M., Meazza, C., Piva, L., Cecchetto, G., Zanetti, I., Pilz, T., Mattke, A., Treuner, J., Carli, M. J. Clin. Oncol. (2002) [Pubmed]
  33. Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR. Lilley, E.R., Elion, G.B., Dewhirst, M.W., Schold, S.C., Blum, M.R., Savina, P.M., Laskowitz, D.T., Bigner, D.D., Friedman, H.S. Cancer Res. (1991) [Pubmed]
  34. Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis. Fuchs, H.E., Archer, G.E., Colvin, O.M., Bigner, S.H., Schuster, J.M., Fuller, G.N., Muhlbaier, L.H., Schold, S.C., Friedman, H.S., Bigner, D.D. Cancer Res. (1990) [Pubmed]
  35. Integrin VLA-2 (alpha2beta1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver. Hangan, D., Uniyal, S., Morris, V.L., MacDonald, I.C., von Ballestrem, C., Chau, T., Schmidt, E.E., Chambers, A.F., Groom, A.C., Chan, B.M. Cancer Res. (1996) [Pubmed]
  36. Expression of functional CD40 on human osteosarcoma and Ewing's sarcoma cells. Lollini, P.L., Landuzzi, L., Frabetti, F., Rossi, I., Nicoletti, G., Scotlandi, K., Serra, M., Baldini, N., De Giovanni, C., Nanni, P. Clin. Cancer Res. (1998) [Pubmed]
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