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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel.

Potassium leak channels are essential to neurophysiological function. Leaks suppress excitability through maintenance of resting membrane potential below the threshold for action potential firing. Conversely, voltage-dependent potassium channels permit excitation because they do not interfere with rise to threshold, and they actively promote recovery and rapid re-firing. Previously attributed to distinct transport pathways, we demonstrate here that phosphorylation of single, native hippocampal and cloned KCNK2 potassium channels produces reversible interconversion between leak and voltage-dependent phenotypes. The findings reveal a pathway for dynamic regulation of excitability.[1]

References

  1. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Bockenhauer, D., Zilberberg, N., Goldstein, S.A. Nat. Neurosci. (2001) [Pubmed]
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