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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Engman, L. et al.

Engman, Kandra, Gallegos, Williams, Powis,

Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells.

The thioredoxin system (NADPH, thioredoxin reductase/ thioredoxin) is important for cancer cell growth and inhibition of apoptosis and presents an attractive target for anticancer drug development. Thioredoxin reductase is a selenocysteine-containing flavoenzyme that catalyzes the reduction of oxidized thioredoxin. This enzyme could therefore be used for regulating the activity of the thioredoxin system. Water-soluble organotellurium compounds of the diaryl telluride, alkyl aryl telluride and dialkyl telluride type, carrying sulfopropyl groups, were found to be the most efficient tellurium-based inhibitors of thioredoxin reductase ever tested. Some of the compounds inhibited the enzyme at submicromolar levels. The compounds also inhibited the growth of MCF-7 and HT-29 human cancer cells in culture at the 5-10 microM level but their hydrophilicity seemed to restrict cellular uptake.[1]

References

Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells. Engman, L., Kandra, T., Gallegos, A., Williams, R., Powis, G. Anticancer Drug Des. (2000) [Pubmed]

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