Gene Review:
TXNRD1 - thioredoxin reductase 1
Homo sapiens
Synonyms:
GRIM-12, GRIM12, Gene associated with retinoic and IFN-induced mortality 12 protein, Gene associated with retinoic and interferon-induced mortality 12 protein, KDRF, ...
- Thioredoxin reductase 1 expression in colon cancer: discrepancy between in vitro and in vivo findings. Lechner, S., Müller-Ladner, U., Neumann, E., Spöttl, T., Schlottmann, K., Rüschoff, J., Schölmerich, J., Kullmann, F. Lab. Invest. (2003)
- Hemolysate thioredoxin reductase and glutathione peroxidase activities correlate with serum selenium in a group of New Zealand men at high prostate cancer risk. Karunasinghe, N., Ferguson, L.R., Tuckey, J., Masters, J. J. Nutr. (2006)
- Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia. Berggren, M., Gallegos, A., Gasdaska, J.R., Gasdaska, P.Y., Warneke, J., Powis, G. Anticancer Res. (1996)
- Convergent evolution of similar function in two structurally divergent enzymes. Kuriyan, J., Krishna, T.S., Wong, L., Guenther, B., Pahler, A., Williams, C.H., Model, P. Nature (1991)
- Properties and biological activities of thioredoxins. Powis, G., Montfort, W.R. Annu. Rev. Pharmacol. Toxicol. (2001)
- The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex. Ratts, R., Zeng, H., Berg, E.A., Blue, C., McComb, M.E., Costello, C.E., vanderSpek, J.C., Murphy, J.R. J. Cell Biol. (2003)
- Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. Mayer, R., Kartenbeck, J., Büchler, M., Jedlitschky, G., Leier, I., Keppler, D. J. Cell Biol. (1995)
- Proteomics gives insight into the regulatory function of chloroplast thioredoxins. Balmer, Y., Koller, A., del Val, G., Manieri, W., Schürmann, P., Buchanan, B.B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Heparin-binding properties of selenium-containing thioredoxin reductase from HeLa cells and human lung adenocarcinoma cells. Liu, S.Y., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors. U-Taniguchi, Y., Furuke, K., Masutani, H., Nakamura, H., Yodoi, J. Oncol. Res. (1995)
- The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli. Arscott, L.D., Gromer, S., Schirmer, R.H., Becker, K., Williams, C.H. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase. Holmgren, A., Lyckeborg, C. Proc. Natl. Acad. Sci. U.S.A. (1980)
- Isolation and characterization of thioredoxin from the cyanobacterium, Anabaena sp. Gleason, F.K., Holmgren, A. J. Biol. Chem. (1981)
- Evidence for intriguingly complex transcription of human thioredoxin reductase 1. Rundlöf, A.K., Janard, M., Miranda-Vizuete, A., Arnér, E.S. Free Radic. Biol. Med. (2004)
- Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine. Anestål, K., Arnér, E.S. J. Biol. Chem. (2003)
- Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II). Sasada, T., Nakamura, H., Ueda, S., Sato, N., Kitaoka, Y., Gon, Y., Takabayashi, A., Spyrou, G., Holmgren, A., Yodoi, J. Free Radic. Biol. Med. (1999)
- Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2. Sakurai, A., Nishimoto, M., Himeno, S., Imura, N., Tsujimoto, M., Kunimoto, M., Hara, S. J. Cell. Physiol. (2005)
- Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium. Gromer, S., Gross, J.H. J. Biol. Chem. (2002)
- 1-Chloro-2,4-dinitrobenzene is an irreversible inhibitor of human thioredoxin reductase. Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity. Arnér, E.S., Björnstedt, M., Holmgren, A. J. Biol. Chem. (1995)
- Mutational analysis of human thioredoxin reductase 1. Effects on p53-mediated gene expression and interferon and retinoic acid-induced cell death. Ma, X., Hu, J., Lindner, D.J., Kalvakolanu, D.V. J. Biol. Chem. (2002)
- An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling. Damdimopoulos, A.E., Miranda-Vizuete, A., Treuter, E., Gustafsson, J.A., Spyrou, G. J. Biol. Chem. (2004)
- Cloning and sequencing of a human thioredoxin reductase. Gasdaska, P.Y., Gasdaska, J.R., Cochran, S., Powis, G. FEBS Lett. (1995)
- Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity. Davioud-Charvet, E., McLeish, M.J., Veine, D.M., Giegel, D., Arscott, L.D., Andricopulo, A.D., Becker, K., Müller, S., Schirmer, R.H., Williams, C.H., Kenyon, G.L. Biochemistry (2003)
- Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation. Karimpour, S., Lou, J., Lin, L.L., Rene, L.M., Lagunas, L., Ma, X., Karra, S., Bradbury, C.M., Markovina, S., Goswami, P.C., Spitz, D.R., Hirota, K., Kalvakolanu, D.V., Yodoi, J., Gius, D. Oncogene (2002)
- (2,2':6',2"-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase. Bonse, S., Richards, J.M., Ross, S.A., Lowe, G., Krauth-Siegel, R.L. J. Med. Chem. (2000)
- A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe. Casso, D., Beach, D. Mol. Gen. Genet. (1996)
- Expression of the thioredoxin-thioredoxin reductase system in the inflamed joints of patients with rheumatoid arthritis. Maurice, M.M., Nakamura, H., Gringhuis, S., Okamoto, T., Yoshida, S., Kullmann, F., Lechner, S., van der Voort, E.A., Leow, A., Versendaal, J., Muller-Ladner, U., Yodoi, J., Tak, P.P., Breedveld, F.C., Verweij, C.L. Arthritis Rheum. (1999)
- Thioredoxin, thioredoxin reductase, and alpha-crystallin revive inactivated glyceraldehyde 3-phosphate dehydrogenase in human aged and cataract lens extracts. Yan, H., Lou, M.F., Fernando, M.R., Harding, J.J. Mol. Vis. (2006)
- Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically. Merrill, C.L., Ni, H., Yoon, L.W., Tirmenstein, M.A., Narayanan, P., Benavides, G.R., Easton, M.J., Creech, D.R., Hu, C.X., McFarland, D.C., Hahn, L.M., Thomas, H.C., Morgan, K.T. Toxicol. Sci. (2002)
- Decreased enzyme activity of hepatic thioredoxin reductase and glutathione reductase in rabbits by prolonged exposure to inorganic arsenate. Nikaido, M., Pi, J., Kumagai, Y., Yamauchi, H., Taguchi, K., Horiguchi, S., Sun, Y., Sun, G., Shimojo, N. Environ. Toxicol. (2003)
- Effect of selenium on rat thioredoxin reductase activity: increase by supranutritional selenium and decrease by selenium deficiency. Berggren, M.M., Mangin, J.F., Gasdaka, J.R., Powis, G. Biochem. Pharmacol. (1999)
- Human thioredoxin reductase gene localization to chromosomal position 12q23-q24.1 and mRNA distribution in human tissue. Gasdaska, J.R., Gasdaska, P.Y., Gallegos, A., Powis, G. Genomics (1996)
- Thioredoxin secreted upon ultraviolet A irradiation modulates activities of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human dermal fibroblasts. Oh, J.H., Chung, A.S., Steinbrenner, H., Sies, H., Brenneisen, P. Arch. Biochem. Biophys. (2004)