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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mapping and promoter sequencing of HNF-1beta gene in diabetes-prone and -resistant mice.

By using a novel single nucleotide polymorphism (SNP) in the coding sequence, the chromosomal location of Tcf2, encoding hepatic nuclear factor (HNF)-1beta, was determined in F2 intercrosses between Nagoya-Shibata-Yasuda (NSY) mice, an animal model of type 2 diabetes, and control C3H/He mice. The promoter region of Tcf2 gene was sequenced in NSY, non-obese diabetic (NOD) and control C3H/He mice. Tcf2 was mapped between genetic markers D11MIT320 and D11MIT195 with the following distances: D11MIT320-(7.3 cM)-Tcf2-(0.5 cM)-D11MIT195. A variant with insertion of C between -205 and -204 in the promoter region of Tcf2 was identified in NSY mice, but not NOD and C3H/He mice.[1]


  1. Mapping and promoter sequencing of HNF-1beta gene in diabetes-prone and -resistant mice. Ueda, H., Ikegami, H., Kawaguchi, Y., Fujisawa, T., Nojima, K., Babaya, N., Yamada, K., Shibata, M., Yamato, E., Ogihara, T. Diabetes Res. Clin. Pract. (2001) [Pubmed]
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