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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CD28 signaling augments Elk-1-dependent transcription at the c-fos gene during antigen stimulation.

Untransformed CD4(+) Th1 cells stimulated with Ag and APC demonstrated a dependence on B7- and CD28- mediated costimulatory signals for the expression and function of AP-1 proteins. The induction of transactivation by the c-fos gene regulator Elk-1 mirrored this requirement for TCR and CD28 signal integration. c-Jun N-terminal kinase ( JNK) (but not extracellular signal-regulated kinase or p38) protein kinase activity was similarly inhibited by neutralizing anti-B7 mAbs. Blockade of JNK protein kinase activity with SB 202190 prevented both Elk-1 transactivation and c-Fos induction. These results identify a unique role for B7 costimulatory molecules and CD28 in the activation of JNK during Ag stimulation in Th1 cells, and suggest that JNK regulates Elk-1 transactivation at the c-fos gene to promote the formation of AP-1 complexes important to IL-2 gene expression.[1]

References

  1. CD28 signaling augments Elk-1-dependent transcription at the c-fos gene during antigen stimulation. Li, W., Whaley, C.D., Bonnevier, J.L., Mondino, A., Martin, M.E., Aagaard-Tillery, K.M., Mueller, D.L. J. Immunol. (2001) [Pubmed]
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