Gene Review:
CD28 - CD28 molecule
Homo sapiens
Synonyms:
T-cell-specific surface glycoprotein CD28, TP44
Greenwald,
Freeman,
Sharpe,
Arosa,
Porto,
Cabeda,
Lacerda,
Resende,
Cruz,
Cardoso,
Fonseca,
Simões,
Rodrigues,
Bravo,
Oliveira,
Alves,
Fraga,
Justiça,
de Sousa,
Ghosh,
Buchholz,
Yano,
Taub,
Longo,
Carreno,
Collins,
Vanhove,
Laflamme,
Coulon,
Mougin,
Vusio,
Haspot,
Tiollier,
Soulillou,
Abrams,
Kelley,
Hayes,
Kikuchi,
Brown,
Kang,
Lebwohl,
Guzzo,
Jegasothy,
Linsley,
Krueger,
Goldman,
Ballas,
Schutte,
Kemp,
Hollenback,
Noraz,
Taylor,
- Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Ott, M., Emiliani, S., Van Lint, C., Herbein, G., Lovett, J., Chirmule, N., McCloskey, T., Pahwa, S., Verdin, E. Science (1997)
- Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. Abrams, J.R., Kelley, S.L., Hayes, E., Kikuchi, T., Brown, M.J., Kang, S., Lebwohl, M.G., Guzzo, C.A., Jegasothy, B.V., Linsley, P.S., Krueger, J.G. J. Exp. Med. (2000)
- Defective expression of p56lck in an infant with severe combined immunodeficiency. Goldman, F.D., Ballas, Z.K., Schutte, B.C., Kemp, J., Hollenback, C., Noraz, N., Taylor, N. J. Clin. Invest. (1998)
- Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 production: implications for multiple myeloma progression. Shapiro, V.S., Mollenauer, M.N., Weiss, A. Blood (2001)
- Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses. Tzachanis, D., Berezovskaya, A., Nadler, L.M., Boussiotis, V.A. Blood (2002)
- Expansions of CD8+CD28- and CD8+TcRVbeta5.2+ T cells in peripheral blood of heavy alcohol drinkers. Arosa, F.A., Porto, G., Cabeda, J.M., Lacerda, R., Resende, D., Cruz, E., Cardoso, C., Fonseca, M., Simões, C., Rodrigues, P., Bravo, F., Oliveira, J.C., Alves, H., Fraga, J., Justiça, B., de Sousa, M. Alcohol. Clin. Exp. Res. (2000)
- The B7 family revisited. Greenwald, R.J., Freeman, G.J., Sharpe, A.H. Annu. Rev. Immunol. (2005)
- The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Carreno, B.M., Collins, M. Annu. Rev. Immunol. (2002)
- Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Salomon, B., Bluestone, J.A. Annu. Rev. Immunol. (2001)
- CD28/B7 system of T cell costimulation. Lenschow, D.J., Walunas, T.L., Bluestone, J.A. Annu. Rev. Immunol. (1996)
- Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element. Verweij, C.L., Geerts, M., Aarden, L.A. J. Biol. Chem. (1991)
- A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. Ruegg, C.L., Strand, M. Cell. Immunol. (1991)
- Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity. West, G.A., Matsuura, T., Levine, A.D., Klein, J.S., Fiocchi, C. Gastroenterology (1996)
- CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activation. Cook, J.A., Albacker, L., August, A., Henderson, A.J. J. Biol. Chem. (2003)
- Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. Cook, J.A., August, A., Henderson, A.J. J. Immunol. (2002)
- The role of the CD28 receptor during T cell responses to antigen. Linsley, P.S., Ledbetter, J.A. Annu. Rev. Immunol. (1993)
- ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Hutloff, A., Dittrich, A.M., Beier, K.C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., Kroczek, R.A. Nature (1999)
- Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Fraser, J.D., Irving, B.A., Crabtree, G.R., Weiss, A. Science (1991)
- CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. Fraser, J.D., Newton, M.E., Weiss, A. J. Exp. Med. (1992)
- p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. Raab, M., Cai, Y.C., Bunnell, S.C., Heyeck, S.D., Berg, L.J., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway. Ghosh, P., Buchholz, M.A., Yano, S., Taub, D., Longo, D.L. Blood (2002)
- Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Bryan, R.G., Li, Y., Lai, J.H., Van, M., Rice, N.R., Rich, R.R., Tan, T.H. Mol. Cell. Biol. (1994)
- Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. Borger, P., Kauffman, H.F., Postma, D.S., Vellenga, E. Blood (1996)
- Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. Fargeas, C.A., Truneh, A., Reddy, M., Hurle, M., Sweet, R., Sékaly, R.P. J. Exp. Med. (1995)
- Essential role for both CD80 and CD86 costimulation, but not CD40 interactions, in allergen-induced Th2 cytokine production from asthmatic bronchial tissue: role for alphabeta, but not gammadelta, T cells. Jaffar, Z.H., Stanciu, L., Pandit, A., Lordan, J., Holgate, S.T., Roberts, K. J. Immunol. (1999)
- Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4. Kapsogeorgou, E.K., Moutsopoulos, H.M., Manoussakis, M.N. J. Immunol. (2001)
- Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B. Costello, R., Lipcey, C., Algarté, M., Cerdan, C., Baeuerle, P.A., Olive, D., Imbert, J. Cell Growth Differ. (1993)
- Activation of p21-CDC42/Rac-activated kinases by CD28 signaling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals. Kaga, S., Ragg, S., Rogers, K.A., Ochi, A. J. Immunol. (1998)
- Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK. King, P.D., Sadra, A., Teng, J.M., Xiao-Rong, L., Han, A., Selvakumar, A., August, A., Dupont, B. J. Immunol. (1997)
- Expression of the co-stimulatory molecule BB-1, the ligands CTLA-4 and CD28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy. Murata, K., Dalakas, M.C. Brain (2000)
- CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28. Slavik, J.M., Hutchcroft, J.E., Bierer, B.E. J. Biol. Chem. (1999)
- Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry. Moriuchi, M., Moriuchi, H., Turner, W., Fauci, A.S. J. Immunol. (1997)
- Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation. Cai, Y.C., Cefai, D., Schneider, H., Raab, M., Nabavi, N., Rudd, C.E. Immunity (1995)
- Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. Vandenberghe, P., Freeman, G.J., Nadler, L.M., Fletcher, M.C., Kamoun, M., Turka, L.A., Ledbetter, J.A., Thompson, C.B., June, C.H. J. Exp. Med. (1992)
- CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. van der Merwe, P.A., Bodian, D.L., Daenke, S., Linsley, P., Davis, S.J. J. Exp. Med. (1997)
- Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen. Cardoso, A.A., Schultze, J.L., Boussiotis, V.A., Freeman, G.J., Seamon, M.J., Laszlo, S., Billet, A., Sallan, S.E., Gribben, J.G., Nadler, L.M. Blood (1996)
- Selective blockade of CD28 and not CTLA-4 with a single-chain Fv-alpha1-antitrypsin fusion antibody. Vanhove, B., Laflamme, G., Coulon, F., Mougin, M., Vusio, P., Haspot, F., Tiollier, J., Soulillou, J.P. Blood (2003)
- The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation. Riley, J.L., June, C.H. Blood (2005)
- Dendritic cells pulsed with an anti-idiotype antibody mimicking carcinoembryonic antigen (CEA) can reverse immunological tolerance to CEA and induce antitumor immunity in CEA transgenic mice. Saha, A., Chatterjee, S.K., Foon, K.A., Primus, F.J., Sreedharan, S., Mohanty, K., Bhattacharya-Chatterjee, M. Cancer Res. (2004)
- CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses. Onodera, K., Chandraker, A., Schaub, M., Stadlbauer, T.H., Korom, S., Peach, R., Linsley, P.S., Sayegh, M.H., Kupiec-Weglinski, J.W. J. Immunol. (1997)