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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Meng, C.Q. et al.

Meng, Zheng, Holt, Hoong, Somers, Hill, Saxena,

Nitrobenzene compounds inhibit expression of VCAM-1.

A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression.[1]

References

Nitrobenzene compounds inhibit expression of VCAM-1. Meng, C.Q., Zheng, X.S., Holt, L.A., Hoong, L.K., Somers, P.K., Hill, R.R., Saxena, U. Bioorg. Med. Chem. Lett. (2001) [Pubmed]

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