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Gene Review

VCAM1  -  vascular cell adhesion molecule 1

Homo sapiens

Synonyms: CD106, INCAM-100, L1CAM, V-CAM 1, VCAM-1, ...
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Disease relevance of VCAM1


Psychiatry related information on VCAM1


High impact information on VCAM1


Chemical compound and disease context of VCAM1


Biological context of VCAM1


Anatomical context of VCAM1

  • The adhesion molecule VCAM1 variant was particularly noteworthy as it was associated with a decrease in B cells, natural killer cells, CD4+ T cells, and monocytes [23].
  • Further, VCAM1 (-1591T>C) and CSF3 (Ex4-165C>T) were associated, respectively, with decreased (P = 0.041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers [23].
  • We have characterized two regions of VCAM1, localized to domains 4 and 5, which are highly sensitive to proteolytic cleavage, localized the epitope of the blocking monoclonal antibody 4B9 to domain 1, and found that domains 1-3 are sufficient for both its adhesive function and its ability to initiate T cell activation [24].
  • Immunoprecipitation of VCAM1 protein from cos7 cells transfected with each cDNA and from cultured endothelial cells followed by deglycosylation suggests that the long form is the major form found on endothelium [25].
  • VCAM1 may play an important role in these diseases because it binds to the integrins very late Ag-4 and alpha(4)beta(7) on lymphocytes and monocytes, thereby providing a potential mechanism to recruit these leukocytes to sites of inflammation [21].

Associations of VCAM1 with chemical compounds


Physical interactions of VCAM1


Regulatory relationships of VCAM1


Other interactions of VCAM1


Analytical, diagnostic and therapeutic context of VCAM1


  1. A fluorescent cellular adhesion assay using insect cell produced human VCAM1. Stoltenborg, J.K., Tsao, P.W., George, H.J., Bouchard, P.J., Wexler, E.J., Hausner, E.A. J. Immunol. Methods (1994) [Pubmed]
  2. Expression and functional characterization of recombinant human vascular cell adhesion molecule-1 (VCAM1) synthesized by baculovirus-infected insect cells. Stoltenborg, J.K., Straney, R.A., Tritch, R.J., Mackin, W.M., George, H.J. Protein Expr. Purif. (1993) [Pubmed]
  3. Identification of astrocytoma associated genes including cell surface markers. Boon, K., Edwards, J.B., Eberhart, C.G., Riggins, G.J. BMC Cancer (2004) [Pubmed]
  4. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. Ockenhouse, C.F., Tegoshi, T., Maeno, Y., Benjamin, C., Ho, M., Kan, K.E., Thway, Y., Win, K., Aikawa, M., Lobb, R.R. J. Exp. Med. (1992) [Pubmed]
  5. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. Kol, A., Bourcier, T., Lichtman, A.H., Libby, P. J. Clin. Invest. (1999) [Pubmed]
  6. Nicotine stimulates adhesion molecular expression via calcium influx and mitogen-activated protein kinases in human endothelial cells. Wang, Y., Wang, Z., Zhou, Y., Liu, L., Zhao, Y., Yao, C., Wang, L., Qiao, Z. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  7. Missense mutations in the extracellular domain of the human neural cell adhesion molecule L1 reduce neurite outgrowth of murine cerebellar neurons. Michelson, P., Hartwig, C., Schachner, M., Gal, A., Veske, A., Finckh, U. Hum. Mutat. (2002) [Pubmed]
  8. Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. Engelhart, M.J., Geerlings, M.I., Meijer, J., Kiliaan, A., Ruitenberg, A., van Swieten, J.C., Stijnen, T., Hofman, A., Witteman, J.C., Breteler, M.M. Arch. Neurol. (2004) [Pubmed]
  9. Endothelial-leukocyte adhesion molecules. Bevilacqua, M.P. Annu. Rev. Immunol. (1993) [Pubmed]
  10. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Ozaki, K., Ohnishi, Y., Iida, A., Sekine, A., Yamada, R., Tsunoda, T., Sato, H., Sato, H., Hori, M., Nakamura, Y., Tanaka, T. Nat. Genet. (2002) [Pubmed]
  11. Circulating activated endothelial cells in sickle cell anemia. Solovey, A., Lin, Y., Browne, P., Choong, S., Wayner, E., Hebbel, R.P. N. Engl. J. Med. (1997) [Pubmed]
  12. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Elices, M.J., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M.E., Lobb, R.R. Cell (1990) [Pubmed]
  13. Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells. Chirivi, R.G., Taraboletti, G., Bani, M.R., Barra, L., Piccinini, G., Giacca, M., Bussolino, F., Giavazzi, R. Blood (1999) [Pubmed]
  14. Regulated expression of vascular cell adhesion molecule-1 in human malignant melanoma. Jonjic, N., Martìn-Padura, I., Pollicino, T., Bernasconi, S., Jílek, P., Bigotti, A., Mortarini, R., Anichini, A., Parmiani, G., Colotta, F. Am. J. Pathol. (1992) [Pubmed]
  15. Soluble vascular cell adhesion molecule 1 mediation of monocyte chemotaxis in rheumatoid arthritis. Tokuhira, M., Hosaka, S., Volin, M.V., Haines, G.K., Katschke, K.J., Kim, S., Koch, A.E. Arthritis Rheum. (2000) [Pubmed]
  16. Expression of vascular cell adhesion molecule-1 in kidney allograft rejection. Alpers, C.E., Hudkins, K.L., Davis, C.L., Marsh, C.L., Riches, W., McCarty, J.M., Benjamin, C.D., Carlos, T.M., Harlan, J.M., Lobb, R. Kidney Int. (1993) [Pubmed]
  17. Serum levels of thrombomodulin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin in the acute phase of Plasmodium vivax malaria. Ohnishi, K. Am. J. Trop. Med. Hyg. (1999) [Pubmed]
  18. Molecular pathways: vcam-1 as a potential therapeutic target in metastasis. Chen, Q., Massagué, J. Clin. Cancer Res. (2012) [Pubmed]
  19. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Cybulsky, M.I., Fries, J.W., Williams, A.J., Sultan, P., Eddy, R., Byers, M., Shows, T., Gimbrone, M.A., Collins, T. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  20. Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. Taylor, J.G., Tang, D.C., Savage, S.A., Leitman, S.F., Heller, S.I., Serjeant, G.R., Rodgers, G.P., Chanock, S.J. Blood (2002) [Pubmed]
  21. I kappa B kinase is critical for TNF-alpha-induced VCAM1 gene expression in renal tubular epithelial cells. Tu, Z., Kelley, V.R., Collins, T., Lee, F.S. J. Immunol. (2001) [Pubmed]
  22. Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1. Neish, A.S., Khachigian, L.M., Park, A., Baichwal, V.R., Collins, T. J. Biol. Chem. (1995) [Pubmed]
  23. Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. Lan, Q., Zhang, L., Shen, M., Smith, M.T., Li, G., Vermeulen, R., Rappaport, S.M., Forrest, M.S., Hayes, R.B., Linet, M., Dosemeci, M., Alter, B.P., Weinberg, R.S., Yin, S., Yeager, M., Welch, R., Waidyanatha, S., Kim, S., Chanock, S., Rothman, N. Cancer Res. (2005) [Pubmed]
  24. Structure/function studies on vascular cell adhesion molecule-1. Pepinsky, B., Hession, C., Chen, L.L., Moy, P., Burkly, L., Jakubowski, A., Chow, E.P., Benjamin, C., Chi-Rosso, G., Luhowskyj, S. J. Biol. Chem. (1992) [Pubmed]
  25. Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1). Hession, C., Tizard, R., Vassallo, C., Schiffer, S.B., Goff, D., Moy, P., Chi-Rosso, G., Luhowskyj, S., Lobb, R., Osborn, L. J. Biol. Chem. (1991) [Pubmed]
  26. Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection. Walker, T., Wendel, H.P., Tetzloff, L., Raabe, C., Heidenreich, O., Simon, P., Scheule, A.M., Ziemer, G. J. Cell. Mol. Med. (2007) [Pubmed]
  27. Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. Besemer, J., Harant, H., Wang, S., Oberhauser, B., Marquardt, K., Foster, C.A., Schreiner, E.P., de Vries, J.E., Dascher-Nadel, C., Lindley, I.J. Nature (2005) [Pubmed]
  28. Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts. Luo, S.F., Fang, R.Y., Hsieh, H.L., Chi, P.L., Lin, C.C., Hsiao, L.D., Wu, C.C., Wang, J.S., Yang, C.M. Arthritis Rheum. (2010) [Pubmed]
  29. Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1. Neish, A.S., Read, M.A., Thanos, D., Pine, R., Maniatis, T., Collins, T. Mol. Cell. Biol. (1995) [Pubmed]
  30. Adhesion receptor profile of thymic B-cell lymphoma. Eichelmann, A., Koretz, K., Mechtersheimer, G., Möller, P. Am. J. Pathol. (1992) [Pubmed]
  31. Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Faruqi, R.M., Poptic, E.J., Faruqi, T.R., De La Motte, C., DiCorleto, P.E. Am. J. Physiol. (1997) [Pubmed]
  32. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Khan, B.V., Harrison, D.G., Olbrych, M.T., Alexander, R.W., Medford, R.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  33. Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium. Vonderheide, R.H., Springer, T.A. J. Exp. Med. (1992) [Pubmed]
  34. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. Marui, N., Offermann, M.K., Swerlick, R., Kunsch, C., Rosen, C.A., Ahmad, M., Alexander, R.W., Medford, R.M. J. Clin. Invest. (1993) [Pubmed]
  35. Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells. Shu, H.B., Agranoff, A.B., Nabel, E.G., Leung, K., Duckett, C.S., Neish, A.S., Collins, T., Nabel, G.J. Mol. Cell. Biol. (1993) [Pubmed]
  36. Regulation of endothelial and mesothelial cell function by interleukin-13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production. Sironi, M., Sciacca, F.L., Matteucci, C., Conni, M., Vecchi, A., Bernasconi, S., Minty, A., Caput, D., Ferrara, P., Colotta, F. Blood (1994) [Pubmed]
  37. Expression of vascular cell adhesion molecule-1 in fibroblastlike synoviocytes after stimulation with tumor necrosis factor. Marlor, C.W., Webb, D.L., Bombara, M.P., Greve, J.M., Blue, M.L. Am. J. Pathol. (1992) [Pubmed]
  38. Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. Morel, J.C., Park, C.C., Zhu, K., Kumar, P., Ruth, J.H., Koch, A.E. J. Biol. Chem. (2002) [Pubmed]
  39. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. Manevich, E., Grabovsky, V., Feigelson, S.W., Alon, R. J. Biol. Chem. (2007) [Pubmed]
  40. Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1. Karmann, K., Min, W., Fanslow, W.C., Pober, J.S. J. Exp. Med. (1996) [Pubmed]
  41. Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism. Burger, J.A., Zvaifler, N.J., Tsukada, N., Firestein, G.S., Kipps, T.J. J. Clin. Invest. (2001) [Pubmed]
  42. Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. Barreiro, O., Yanez-Mo, M., Serrador, J.M., Montoya, M.C., Vicente-Manzanares, M., Tejedor, R., Furthmayr, H., Sanchez-Madrid, F. J. Cell Biol. (2002) [Pubmed]
  43. Effect of vascular stent alloys on expression of cellular adhesion molecules by endothelial cells. Messer, R.L., Wataha, J.C., Lewis, J.B., Lockwood, P.E., Caughman, G.B., Tseng, W.Y. Journal of long-term effects of medical implants. (2005) [Pubmed]
  44. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. Bochner, B.S., Luscinskas, F.W., Gimbrone, M.A., Newman, W., Sterbinsky, S.A., Derse-Anthony, C.P., Klunk, D., Schleimer, R.P. J. Exp. Med. (1991) [Pubmed]
  45. Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. Cid, M.C., Kleinman, H.K., Grant, D.S., Schnaper, H.W., Fauci, A.S., Hoffman, G.S. J. Clin. Invest. (1994) [Pubmed]
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