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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Myosin I mutants with only 1% of wild-type actin-activated MgATPase activity retain essential in vivo function(s).

The single class I myosin (MYOA) of Aspergillus nidulans is essential for hyphal growth. It is generally assumed that the functions of all myosins depend on their actin-activated MgATPase activity. Here we show that MYOA mutants with no more than 1% of the actin-activated MgATPase activity of wild-type MYOA in vitro and no detectable in vitro motility activity can support fungal cell growth, albeit with a delay in germination time and a reduction in hyphal elongation. From these and other data, we conclude that the essential role(s) of myosin I in A. nidulans is probably structural, requiring little, if any, actin-activated MgATPase or motor activity, which have long been considered the defining characteristics of the myosin family.[1]

References

  1. Myosin I mutants with only 1% of wild-type actin-activated MgATPase activity retain essential in vivo function(s). Liu, X., Osherov, N., Yamashita, R., Brzeska, H., Korn, E.D., May, G.S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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