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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Use of primed in situ labeling (PRINS) for the detection of telomeric deletions associated with mental retardation.

Rearrangements involving the telomeric regions of human chromosomes are often associated with mental retardation. These rearrangements, however, are difficult to detect using conventional cytogenetic techniques. We propose the use of primed in situ (PRINS) labeling as an alternative to fluorescence in situ hybridization because it is very fast, reproducible, and simple to perform. Sixty-five children with unexplained mental retardation were studied using PRINS technology; two of them were shown to have a telomeric deletion.[1]

References

  1. Use of primed in situ labeling (PRINS) for the detection of telomeric deletions associated with mental retardation. Bonifacio, S., Centrone, C., Da Prato, L., Scordo, M.R., Estienne, M., Torricelli, F. Cytogenet. Cell Genet. (2001) [Pubmed]
 
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