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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The opioid peptide analogue biphalin induces less physical dependence than morphine.

We compared the physical dependence liability of biphalin, a dimeric enkephalin analogue that possesses high antinociceptive activity, with that of morphine in equipotent intravenous doses. Naloxone challenge produced severe withdrawal signs after a 5-day infusion of morphine but only minor withdrawal signs after a 5-day biphalin infusion. In a cross-dependence study, biphalin did not suppress body weight loss after morphine withdrawal, but successfully suppressed weight loss after pentazocine withdrawal. These data support consideration of biphalin as a new analgesic with a novel pharmacological profile and minimum dependence liability.[1]

References

  1. The opioid peptide analogue biphalin induces less physical dependence than morphine. Yamazaki, M., Suzuki, T., Narita, M., Lipkowski, A.W. Life Sci. (2001) [Pubmed]
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