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Roush, W.R. et al.

Roush, Cheng, Knapp-Reed, Alvarez-Hernandez, McKerrow, Hansell, Engel,

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.

A new family of potent N-alkoxyvinylsulfonamide inhibitors of cruzain have been developed. Inhibitor 13 has a second order inactivation rate constant of 6,480,000s(-1)M(-1) versus cruzain, and is also highly effective against Trypanosoma cruzi trypomastigotes in a tissue culture assay.[1]

References

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. Roush, W.R., Cheng, J., Knapp-Reed, B., Alvarez-Hernandez, A., McKerrow, J.H., Hansell, E., Engel, J.C. Bioorg. Med. Chem. Lett. (2001) [Pubmed]

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