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Disease relevance of Trypanosoma


Psychiatry related information on Trypanosoma


High impact information on Trypanosoma


Chemical compound and disease context of Trypanosoma


Biological context of Trypanosoma


Anatomical context of Trypanosoma


Associations of Trypanosoma with chemical compounds

  • Protective immunisation of mice using cell surface glycoprotein from Trypanosoma cruzi [27].
  • Recently, we have shown that activation of the VSG-1 gene in the BoTaR (Bordeaux trypanozoon antigen repertoire) serodeme of Trypanosoma equiperdum involves the duplication and transposition of a telomeric BC gene into one of at least three unlinked telomeric sites [28].
  • When the infected mammalian host of Trypanosoma brucei brucei is injected with a solution of the iron chelator salicyl hydroxamic acid and glycerol, the aerobic and anaerobic glucose catabolism of the parasite is blocked and the parasite is rapidly destroyed [29].
  • The synergistic effect of serum on the drug combination of salicylhydroxamic acid plus glycerol, which is active against Trypanosoma brucei, is due to diffusible calcium ions [30].
  • The ability of the compound to inhibit ornithine decarboxylase in vitro was demonstrated by the reduced amounts of putrescine synthesized from tritiated ornithine in Trypanosoma brucei suspensions [31].

Gene context of Trypanosoma


Analytical, diagnostic and therapeutic context of Trypanosoma


  1. Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. Montamat, E.E., Burgos, C., Gerez de Burgos, N.M., Rovai, L.E., Blanco, A., Segura, E.L. Science (1982) [Pubmed]
  2. Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet). Docampo, R., Moreno, S.N., Muniz, R.P., Cruz, F.S., Mason, R.P. Science (1983) [Pubmed]
  3. A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia. Vassella, E., Den Abbeele, J.V., Bütikofer, P., Renggli, C.K., Furger, A., Brun, R., Roditi, I. Genes Dev. (2000) [Pubmed]
  4. Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. Kubata, B.K., Duszenko, M., Kabututu, Z., Rawer, M., Szallies, A., Fujimori, K., Inui, T., Nozaki, T., Yamashita, K., Horii, T., Urade, Y., Hayaishi, O. J. Exp. Med. (2000) [Pubmed]
  5. Circulating antibodies to mouse laminin in Chagas disease, American cutaneous leishmaniasis, and normal individuals recognize terminal galactosyl(alpha 1-3)-galactose epitopes. Towbin, H., Rosenfelder, G., Wieslander, J., Avila, J.L., Rojas, M., Szarfman, A., Esser, K., Nowack, H., Timpl, R. J. Exp. Med. (1987) [Pubmed]
  6. Trypanosomes cause dysregulation of c-fos expression in the rat suprachiasmatic nucleus. Bentivoglio, M., Grassi-Zucconi, G., Peng, Z.C., Bassetti, A., Edlund, C., Kristensson, K. Neuroreport (1994) [Pubmed]
  7. A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense. Xong, H.V., Vanhamme, L., Chamekh, M., Chimfwembe, C.E., Van Den Abbeele, J., Pays, A., Van Meirvenne, N., Hamers, R., De Baetselier, P., Pays, E. Cell (1998) [Pubmed]
  8. A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei. Horn, D., Cross, G.A. Cell (1995) [Pubmed]
  9. Kinetoplastid RNA editing: in vitro formation of cytochrome b gRNA-mRNA chimeras from synthetic substrate RNAs. Harris, M.E., Hajduk, S.L. Cell (1992) [Pubmed]
  10. In trypanosomes the homolog of the largest subunit of RNA polymerase II is encoded by two genes and has a highly unusual C-terminal domain structure. Smith, J.L., Levin, J.R., Ingles, C.J., Agabian, N. Cell (1989) [Pubmed]
  11. Extensive editing of the cytochrome c oxidase III transcript in Trypanosoma brucei. Feagin, J.E., Abraham, J.M., Stuart, K. Cell (1988) [Pubmed]
  12. Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness. Pepin, J., Milord, F., Guern, C., Schechter, P.J. Lancet (1987) [Pubmed]
  13. Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei. Roper, J.R., Guther, M.L., Milne, K.G., Ferguson, M.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  14. A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Kennedy, P.G., Rodgers, J., Jennings, F.W., Murray, M., Leeman, S.E., Burke, J.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  15. Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. Clarkson, A.B., Bacchi, C.J., Mellow, G.H., Nathan, H.C., McCann, P.P., Sjoerdsma, A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  16. Inhibition of antibody-dependent eosinophil-mediated cytotoxicity by heparin. Kierszenbaum, F., Ackerman, S.J., Gleich, G.J. J. Immunol. (1982) [Pubmed]
  17. Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei. ten Asbroek, A.L., Ouellette, M., Borst, P. Nature (1990) [Pubmed]
  18. Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei. Roditi, I., Schwarz, H., Pearson, T.W., Beecroft, R.P., Liu, M.K., Richardson, J.P., Bühring, H.J., Pleiss, J., Bülow, R., Williams, R.O. J. Cell Biol. (1989) [Pubmed]
  19. Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes. Hutchings, N.R., Donelson, J.E., Hill, K.L. J. Cell Biol. (2002) [Pubmed]
  20. Intracellular colocalization of variant surface glycoprotein and transferrin-gold in Trypanosoma brucei. Webster, P., Grab, D.J. J. Cell Biol. (1988) [Pubmed]
  21. Gene activation and re-expression of a Trypanosoma brucei variant surface glycoprotein. Michiels, F., Matthyssens, G., Kronenberger, P., Pays, E., Dero, B., Van Assel, S., Darville, M., Carvador, A., Steinert, M., Hamers, R. EMBO J. (1983) [Pubmed]
  22. RNA editing: transfer of genetic information from gRNA to precursor mRNA in vitro. Seiwert, S.D., Stuart, K. Science (1994) [Pubmed]
  23. Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. Reed, S.G., Nathan, C.F., Pihl, D.L., Rodricks, P., Shanebeck, K., Conlon, P.J., Grabstein, K.H. J. Exp. Med. (1987) [Pubmed]
  24. Antibodies to laminin in Chagas' disease. Szarfman, A., Terranova, V.P., Rennard, S.I., Foidart, J.M., de Fatima Lima, M., Scheinman, J.I., Martin, G.R. J. Exp. Med. (1982) [Pubmed]
  25. A neuraminidase from Trypanosoma cruzi removes sialic acid from the surface of mammalian myocardial and endothelial cells. Libby, P., Alroy, J., Pereira, M.E. J. Clin. Invest. (1986) [Pubmed]
  26. Cerebral vessel laminins and IFN-gamma define Trypanosoma brucei brucei penetration of the blood-brain barrier. Masocha, W., Robertson, B., Rottenberg, M.E., Mhlanga, J., Sorokin, L., Kristensson, K. J. Clin. Invest. (2004) [Pubmed]
  27. Protective immunisation of mice using cell surface glycoprotein from Trypanosoma cruzi. Scott, M.T., Snary, D. Nature (1979) [Pubmed]
  28. Stability of expression-linked surface antigen gene in Trypanosoma equiperdum. Buck, G.A., Longacre, S., Raibaud, A., Hibner, U., Giroud, C., Baltz, T., Baltz, D., Eisen, H. Nature (1984) [Pubmed]
  29. Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism. Clarkson, A.B., Brohn, F.H. Science (1976) [Pubmed]
  30. Role of calcium in trypanocidal drug action. Clarkson, A.B., Amole, B.O. Science (1982) [Pubmed]
  31. Polyamine metabolism: a potential therapeutic target in trypanosomes. Bacchi, C.J., Nathan, H.C., Hutner, S.H., McCann, P.P., Sjoerdsma, A. Science (1980) [Pubmed]
  32. Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Tarleton, R.L., Koller, B.H., Latour, A., Postan, M. Nature (1992) [Pubmed]
  33. Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. Silva, J.S., Morrissey, P.J., Grabstein, K.H., Mohler, K.M., Anderson, D., Reed, S.G. J. Exp. Med. (1992) [Pubmed]
  34. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human beta 1-adrenergic receptor. Ferrari, I., Levin, M.J., Wallukat, G., Elies, R., Lebesgue, D., Chiale, P., Elizari, M., Rosenbaum, M., Hoebeke, J. J. Exp. Med. (1995) [Pubmed]
  35. Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNP. Lücke, S., Klöckner, T., Palfi, Z., Boshart, M., Bindereif, A. EMBO J. (1997) [Pubmed]
  36. GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits. Nagamune, K., Ohishi, K., Ashida, H., Hong, Y., Hino, J., Kangawa, K., Inoue, N., Maeda, Y., Kinoshita, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  37. High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase. Craig, S.P., Yuan, L., Kuntz, D.A., McKerrow, J.H., Wang, C.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  38. Synthesis and processing of kinetoplast DNA minicircles in Trypanosoma equiperdum. Ryan, K.A., Englund, P.T. Mol. Cell. Biol. (1989) [Pubmed]
  39. Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence, expression, and molecular analysis. Pellé, R., Schramm, V.L., Parkin, D.W. J. Biol. Chem. (1998) [Pubmed]
  40. Subcellular distribution of particle-associated antigens in Trypanosoma rhodesiense. McLaughlin, J. J. Immunol. (1982) [Pubmed]
  41. Trypanosomal immunosuppressive factor: a secretion product(s) of Trypanosoma cruzi that inhibits proliferation and IL-2 receptor expression by activated human peripheral blood mononuclear cells. Kierszenbaum, F., Cuna, W.R., Beltz, L.A., Sztein, M.B. J. Immunol. (1990) [Pubmed]
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