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MeSH Review

Trypanosoma

 
 
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Disease relevance of Trypanosoma

 

Psychiatry related information on Trypanosoma

 

High impact information on Trypanosoma

 

Chemical compound and disease context of Trypanosoma

 

Biological context of Trypanosoma

 

Anatomical context of Trypanosoma

 

Associations of Trypanosoma with chemical compounds

  • Protective immunisation of mice using cell surface glycoprotein from Trypanosoma cruzi [27].
  • Recently, we have shown that activation of the VSG-1 gene in the BoTaR (Bordeaux trypanozoon antigen repertoire) serodeme of Trypanosoma equiperdum involves the duplication and transposition of a telomeric BC gene into one of at least three unlinked telomeric sites [28].
  • When the infected mammalian host of Trypanosoma brucei brucei is injected with a solution of the iron chelator salicyl hydroxamic acid and glycerol, the aerobic and anaerobic glucose catabolism of the parasite is blocked and the parasite is rapidly destroyed [29].
  • The synergistic effect of serum on the drug combination of salicylhydroxamic acid plus glycerol, which is active against Trypanosoma brucei, is due to diffusible calcium ions [30].
  • The ability of the compound to inhibit ornithine decarboxylase in vitro was demonstrated by the reduced amounts of putrescine synthesized from tritiated ornithine in Trypanosoma brucei suspensions [31].
 

Gene context of Trypanosoma

 

Analytical, diagnostic and therapeutic context of Trypanosoma

References

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  2. Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet). Docampo, R., Moreno, S.N., Muniz, R.P., Cruz, F.S., Mason, R.P. Science (1983) [Pubmed]
  3. A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia. Vassella, E., Den Abbeele, J.V., Bütikofer, P., Renggli, C.K., Furger, A., Brun, R., Roditi, I. Genes Dev. (2000) [Pubmed]
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  13. Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei. Roper, J.R., Guther, M.L., Milne, K.G., Ferguson, M.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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  19. Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes. Hutchings, N.R., Donelson, J.E., Hill, K.L. J. Cell Biol. (2002) [Pubmed]
  20. Intracellular colocalization of variant surface glycoprotein and transferrin-gold in Trypanosoma brucei. Webster, P., Grab, D.J. J. Cell Biol. (1988) [Pubmed]
  21. Gene activation and re-expression of a Trypanosoma brucei variant surface glycoprotein. Michiels, F., Matthyssens, G., Kronenberger, P., Pays, E., Dero, B., Van Assel, S., Darville, M., Carvador, A., Steinert, M., Hamers, R. EMBO J. (1983) [Pubmed]
  22. RNA editing: transfer of genetic information from gRNA to precursor mRNA in vitro. Seiwert, S.D., Stuart, K. Science (1994) [Pubmed]
  23. Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. Reed, S.G., Nathan, C.F., Pihl, D.L., Rodricks, P., Shanebeck, K., Conlon, P.J., Grabstein, K.H. J. Exp. Med. (1987) [Pubmed]
  24. Antibodies to laminin in Chagas' disease. Szarfman, A., Terranova, V.P., Rennard, S.I., Foidart, J.M., de Fatima Lima, M., Scheinman, J.I., Martin, G.R. J. Exp. Med. (1982) [Pubmed]
  25. A neuraminidase from Trypanosoma cruzi removes sialic acid from the surface of mammalian myocardial and endothelial cells. Libby, P., Alroy, J., Pereira, M.E. J. Clin. Invest. (1986) [Pubmed]
  26. Cerebral vessel laminins and IFN-gamma define Trypanosoma brucei brucei penetration of the blood-brain barrier. Masocha, W., Robertson, B., Rottenberg, M.E., Mhlanga, J., Sorokin, L., Kristensson, K. J. Clin. Invest. (2004) [Pubmed]
  27. Protective immunisation of mice using cell surface glycoprotein from Trypanosoma cruzi. Scott, M.T., Snary, D. Nature (1979) [Pubmed]
  28. Stability of expression-linked surface antigen gene in Trypanosoma equiperdum. Buck, G.A., Longacre, S., Raibaud, A., Hibner, U., Giroud, C., Baltz, T., Baltz, D., Eisen, H. Nature (1984) [Pubmed]
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  30. Role of calcium in trypanocidal drug action. Clarkson, A.B., Amole, B.O. Science (1982) [Pubmed]
  31. Polyamine metabolism: a potential therapeutic target in trypanosomes. Bacchi, C.J., Nathan, H.C., Hutner, S.H., McCann, P.P., Sjoerdsma, A. Science (1980) [Pubmed]
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  33. Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. Silva, J.S., Morrissey, P.J., Grabstein, K.H., Mohler, K.M., Anderson, D., Reed, S.G. J. Exp. Med. (1992) [Pubmed]
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  35. Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNP. Lücke, S., Klöckner, T., Palfi, Z., Boshart, M., Bindereif, A. EMBO J. (1997) [Pubmed]
  36. GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits. Nagamune, K., Ohishi, K., Ashida, H., Hong, Y., Hino, J., Kangawa, K., Inoue, N., Maeda, Y., Kinoshita, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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