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Chemical Compound Review

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Disease relevance of AIDS-059356


Psychiatry related information on AIDS-059356

  • When the condition of a patient with nocardiosis falls to improve on sulfonamide therapy, patient compliance should be questioned, serum sulfonamide levels should be measured, cultures and susceptibility studies should be repeated, and a search for sequestered pus should be made [5].
  • Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease [6].

High impact information on AIDS-059356


Chemical compound and disease context of AIDS-059356


Biological context of AIDS-059356

  • RSF1010 is a 5.5 X 10(6) dalton nonconjugative plasmid which confers resistance to streptomycin and sulfonamide [16].
  • Pretreatment of cells with a blocker of protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide (H-89), prevented the effect of 8-(4-chlorophenylthio)cAMP while not affecting the background shift in kinetics [17].
  • Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell-cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer [18].
  • The growth inhibitory activity of sulfonamide anilides against human cancer cells in vitro is reversible and is dependent on the induction of histone acetylation [19].
  • These effects, of the naphthalene sulfonamide calmodulin antagonists, are consistent with a regulatory role for calmodulin in cell differentiation, but parallel effects on protein kinase C cannot be excluded [20].

Anatomical context of AIDS-059356


Associations of AIDS-059356 with other chemical compounds


Gene context of AIDS-059356


Analytical, diagnostic and therapeutic context of AIDS-059356


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  2. Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity. Shear, N.H., Spielberg, S.P., Grant, D.M., Tang, B.K., Kalow, W. Ann. Intern. Med. (1986) [Pubmed]
  3. Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases. Wise, E.M., Abou-Donia, M.M. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  4. The liver in the acquired immunodeficiency syndrome: a clinical and histologic study. Lebovics, E., Thung, S.N., Schaffner, F., Radensky, P.W. Hepatology (1985) [Pubmed]
  5. Failure of sulfonamides and trimethoprim in the treatment of nocardiosis. Stamm, A.M., McFall, D.W., Dismukes, W.E. Arch. Intern. Med. (1983) [Pubmed]
  6. Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease. Rishton, G.M., Retz, D.M., Tempest, P.A., Novotny, J., Kahn, S., Treanor, J.J., Lile, J.D., Citron, M. J. Med. Chem. (2000) [Pubmed]
  7. Primary cutaneous nocardiosis. Satterwhite, T.K., Wallace, R.J. JAMA (1979) [Pubmed]
  8. Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase. Allegra, C.J., Boarman, D., Kovacs, J.A., Morrison, P., Beaver, J., Chabner, B.A., Masur, H. J. Clin. Invest. (1990) [Pubmed]
  9. Trifluoperazine inhibits phagocytosis in a macrophagelike cultured cell line. Horwitz, S.B., Chia, G.H., Harracksingh, C., Orlow, S., Pifko-Hirst, S., Schneck, J., Sorbara, L., Speaker, M., Wilk, E.W., Rosen, O.M. J. Cell Biol. (1981) [Pubmed]
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  11. Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8(+) cells by the hydroxylamine of sulfamethoxazole. Hess, D.A., Sisson, M.E., Suria, H., Wijsman, J., Puvanesasingham, R., Madrenas, J., Rieder, M.J. FASEB J. (1999) [Pubmed]
  12. The diuretic indapamide increases bone mass and decreases bone resorption in spontaneously hypertensive rats supplemented with sodium. Lalande, A., Roux, C., Graulet, A.M., Schiavi, P., De Vernejoul, M.C. J. Bone Miner. Res. (1998) [Pubmed]
  13. Assessment of therapy for toxoplasma encephalitis. The TE Study Group. Haverkos, H.W. Am. J. Med. (1987) [Pubmed]
  14. Sulfonamide-induced hypoglycemia in chronic renal failure. Arem, R., Garber, A.J., Field, J.B. Arch. Intern. Med. (1983) [Pubmed]
  15. Trimethoprim and sulfonamide-associated meningoencephalitis with MRI correlates. Blumenfeld, H., Cha, J.H., Cudkowicz, M.E. Neurology (1996) [Pubmed]
  16. Translocation of a plasmid DNA sequence which mediates ampicillin resistance: molecular nature and specificity of insertion. Heffron, F., Rubens, C., Falkow, S. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  17. Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. Ono, K., Fozzard, H.A., Hanck, D.A. Circ. Res. (1993) [Pubmed]
  18. Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell-cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer. Raymond, E., ten Bokkel Huinink, W.W., Taïeb, J., Beijnen, J.H., Faivre, S., Wanders, J., Ravic, M., Fumoleau, P., Armand, J.P., Schellens, J.H. J. Clin. Oncol. (2002) [Pubmed]
  19. Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors. Fournel, M., Trachy-Bourget, M.C., Yan, P.T., Kalita, A., Bonfils, C., Beaulieu, C., Frechette, S., Leit, S., Abou-Khalil, E., Woo, S.H., Delorme, D., MacLeod, A.R., Besterman, J.M., Li, Z. Cancer Res. (2002) [Pubmed]
  20. Induction of myeloid differentiation of HL-60 cells with naphthalene sulfonamide calmodulin antagonists. Veigl, M.L., Sedwick, W.D., Niedel, J., Branch, M.E. Cancer Res. (1986) [Pubmed]
  21. Carbonic anhydrase in the membrane of the endoplasmic reticulum of male rat liver. Ono, Y., Ridderstråle, Y., Forster, R.E., Chu, Z.G., Dodgson, S.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells: comparison of Schwann cells with other cell types. Matsuoka, I., Meyer, M., Thoenen, H. J. Neurosci. (1991) [Pubmed]
  23. Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. Funahashi, Y., Sugi, N.H., Semba, T., Yamamoto, Y., Hamaoka, S., Tsukahara-Tamai, N., Ozawa, Y., Tsuruoka, A., Nara, K., Takahashi, K., Okabe, T., Kamata, J., Owa, T., Ueda, N., Haneda, T., Yonaga, M., Yoshimatsu, K., Wakabayashi, T. Cancer Res. (2002) [Pubmed]
  24. Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones. von Greyerz, S., Zanni, M.P., Frutig, K., Schnyder, B., Burkhart, C., Pichler, W.J. J. Immunol. (1999) [Pubmed]
  25. Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum. Triglia, T., Cowman, A.F. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  26. Mechanism of action of angiotensin II and bradykinin on prostaglandin synthesis and vascular tone in the isolated rat kidney. Effect of Ca++ antagonists and calmodulin inhibitors. Cooper, C.L., Shaffer, J.E., Malik, K.U. Circ. Res. (1985) [Pubmed]
  27. The CTX-M beta-lactamase pandemic. Cantón, R., Coque, T.M. Curr. Opin. Microbiol. (2006) [Pubmed]
  28. Inhibitors of transcription such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxyl-terminal domain of RNA polymerase II largest subunit. Dubois, M.F., Nguyen, V.T., Bellier, S., Bensaude, O. J. Biol. Chem. (1994) [Pubmed]
  29. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. Lee, D., Long, S.A., Adams, J.L., Chan, G., Vaidya, K.S., Francis, T.A., Kikly, K., Winkler, J.D., Sung, C.M., Debouck, C., Richardson, S., Levy, M.A., DeWolf, W.E., Keller, P.M., Tomaszek, T., Head, M.S., Ryan, M.D., Haltiwanger, R.C., Liang, P.H., Janson, C.A., McDevitt, P.J., Johanson, K., Concha, N.O., Chan, W., Abdel-Meguid, S.S., Badger, A.M., Lark, M.W., Nadeau, D.P., Suva, L.J., Gowen, M., Nuttall, M.E. J. Biol. Chem. (2000) [Pubmed]
  30. Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Owa, T., Yoshino, H., Yoshimatsu, K., Nagasu, T. Current medicinal chemistry. (2001) [Pubmed]
  31. Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. Nishimori, I., Vullo, D., Innocenti, A., Scozzafava, A., Mastrolorenzo, A., Supuran, C.T. J. Med. Chem. (2005) [Pubmed]
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  33. 1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2. Khanna, I.K., Weier, R.M., Yu, Y., Collins, P.W., Miyashiro, J.M., Koboldt, C.M., Veenhuizen, A.W., Currie, J.L., Seibert, K., Isakson, P.C. J. Med. Chem. (1997) [Pubmed]
  34. The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants. Paulsen, I.T., Littlejohn, T.G., Rådström, P., Sundström, L., Sköld, O., Swedberg, G., Skurray, R.A. Antimicrob. Agents Chemother. (1993) [Pubmed]
  35. Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor. Nair, S.K., Elbaum, D., Christianson, D.W. J. Biol. Chem. (1996) [Pubmed]
  36. Pharmacological and biochemical evidence for the regulation of osteocalcin secretion by potassium channels in human osteoblast-like MG-63 cells. Moreau, R., Aubin, R., Lapointe, J.Y., Lajeunesse, D. J. Bone Miner. Res. (1997) [Pubmed]
  37. pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation. Lowe, M.P., Parker, D., Reany, O., Aime, S., Botta, M., Castellano, G., Gianolio, E., Pagliarin, R. J. Am. Chem. Soc. (2001) [Pubmed]
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