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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hägerstrand, H. et al.

Hägerstrand, Iglic, Bobrowska-Hägerstrand, Lindqvist, Isomaa, Eber,

Amphiphile-induced vesiculation in aged hereditary spherocytosis erythrocytes indicates normal membrane stability properties under non-starving conditions.

Aged HS erythrocytes with a defined primary defect in band 3 protein or ankyrin were incubated with amphiphiles (detergents) at sublytic concentrations (37 C, 60 min) or glucose-starved (37 C, 24 h). In line with previous studies, the release of AChE (exovesicles) from HS erythrocytes during glucose-starvation was significantly higher (11%) compared to that from control erythrocytes (1%). Control and HS cells responded, however, similarly to amphiphile-treatment (non-starving conditions). Amphiphiles induced similar types of shape alterations and a similar amount of AChE release (14-15%). Furthermore, the size and shape of amphiphile-induced exo- and endovesicles released from control and HS erythrocytes were similar. The results suggest that the stability properties of the membrane are not seriously disturbed in aged HS erythrocytes under non-starving conditions.[1]

References

Amphiphile-induced vesiculation in aged hereditary spherocytosis erythrocytes indicates normal membrane stability properties under non-starving conditions. Hägerstrand, H., Iglic, A., Bobrowska-Hägerstrand, M., Lindqvist, C., Isomaa, B., Eber, S. Mol. Membr. Biol. (2001) [Pubmed]

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