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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Blockade of caspases inhibits amebic liver abscess formation in a mouse model of disease.

We looked at the effect of inhibiting caspases on amebic liver abscess in the mouse model of infection. A dose of the pan-caspase inhibitor benzyloxycarbonyl-V-A-D-O-methyl fluoromethyl ketone (Z-VAD-FMK; R & D Systems) given to SCID mice 2 h prior to direct hepatic inoculation with Entamoeba histolytica trophozoites, and 12 h after amebic inoculation, reduced the mean liver abscess size by 70% at 24 h compared to a control group. These data indicate that apoptosis plays a significant but not an exclusive role in amebic liver abscess formation in the mouse model.[1]

References

  1. Blockade of caspases inhibits amebic liver abscess formation in a mouse model of disease. Yan, L., Stanley, S.L. Infect. Immun. (2001) [Pubmed]
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