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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Synthesis of a nitrogen analogue of salacinol and its alpha-glucosidase inhibitory activity.

A nitrogen analogue 4 of the naturally occurring sulfonium ion salacinol (1), a potent alpha-glucosidase inhibitor isolated from the Ayruvedic medicine Salacia reticulata, was synthesized and its inhibitory activity against alpha-glucosidase tested. Substitution of the sulfur atom in 1 with a nitrogen reduced the activity considerably. The solid-state stereostructure of the related compound (5) was determined on the basis of single crystal X-ray measurement.[1]

References

  1. Synthesis of a nitrogen analogue of salacinol and its alpha-glucosidase inhibitory activity. Muraoka, O., Ying, S., Yoshikai, K., Matsuura, Y., Yamada, E., Minematsu, T., Tanabe, G., Matsuda, H., Yoshikawa, M. Chem. Pharm. Bull. (2001) [Pubmed]
 
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