New glimpses of an old machine.
Two recent studies illustrate the ability of the Mre11/Rad50 DNA repair complex to bind and connect DNA ends. Specific stimulation of DNA ligase IV- mediated end-joining by Mre11 complexes from S. cerevisiae suggests the possibility of a direct role in nonhomologous end-joining in eukaryotic cells.[1]References
- New glimpses of an old machine. Paull, T.T. Cell (2001) [Pubmed]
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