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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5.

Worby and Margolis highlight advances in our understanding of signaling from growth factor receptors using the worm Caenorhabditis elegans as a model organism. ARK-1, a cytoplasmic tyrosine kinase, appears to be a negative regulator of multiple pathways in C. elegans. The authors discuss several models for how this negative regulation may occur. The adaptor protein (Grb2 in mammals or SEM-5 in C. elegans) may serve as a regulated scaffold for the binding of other signaling proteins that include both positive (Ras) and negative (ACK) regulators. Thus, Grb2 may function in a cellular decision point for transducing the incoming signals.[1]

References

  1. Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5. Worby, C., Margolis, B. Sci. STKE (2000) [Pubmed]
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