Gene Review:
TNK2 - tyrosine kinase, non-receptor, 2
Homo sapiens
Synonyms:
ACK, ACK-1, ACK1, Activated CDC42 kinase 1, Tyrosine kinase non-receptor protein 2, ...
- Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. Mahajan, K., Mahajan, N.P. J. Cell. Physiol. (2010)
- Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Mahajan, N.P., Whang, Y.E., Mohler, J.L., Earp, H.S. Cancer. Res. (2005)
- Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Mahajan, N.P., Liu, Y., Majumder, S., Warren, M.R., Parker, C.E., Mohler, J.L., Earp, H.S., Whang, Y.E. Proc. Natl. Acad. Sci. U. S. A. (2007)
- Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. Mahajan, K., Coppola, D., Challa, S., Fang, B., Chen, Y.A., Zhu, W., Lopez, A.S., Koomen, J., Engelman, R.W., Rivera, C., Muraoka-Cook, R.S., Cheng, J.Q., Schönbrunn, E., Sebti, S.M., Earp, H.S., Mahajan, N.P. PLoS. One. (2010)
- Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Mahajan, K., Coppola, D., Chen, Y.A., Zhu, W., Lawrence, H.R., Lawrence, N.J., Mahajan, N.P. Am. J. Pathol. (2012)
- Ack1 mediated androgen receptor phosphorylation modulates radiation resistance in castration resistant prostate cancer. Mahajan, K., Coppola, D., Rawal, B., Chen, Y.A., Lawrence, H.R., Engelman, R.W., Lawrence, N.J., Mahajan, N.P. J. Biol. Chem. (2012)
- Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Mahajan, K., Challa, S., Coppola, D., Lawrence, H., Luo, Y., Gevariya, H., Zhu, W., Chen, Y.A., Lawrence, N.J., Mahajan, N.P. Prostate. (2010)
- Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. van der Horst, E.H., Degenhardt, Y.Y., Strelow, A., Slavin, A., Chinn, L., Orf, J., Rong, M., Li, S., See, L.H., Nguyen, K.Q., Hoey, T., Wesche, H., Powers, S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. Linseman, D.A., Heidenreich, K.A., Fisher, S.K. J. Biol. Chem. (2001)
- Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Mahajan, N.P., Whang, Y.E., Mohler, J.L., Earp, H.S. Cancer Res. (2005)
- Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. Yokoyama, N., Miller, W.T. J. Biol. Chem. (2003)
- Use of the MMPI-A to detect substance abuse in a juvenile correctional setting. Stein, L.A., Graham, J.R. Journal of personality assessment. (2001)
- Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK. Mott, H.R., Owen, D., Nietlispach, D., Lowe, P.N., Manser, E., Lim, L., Laue, E.D. Nature (1999)
- Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation. Satoh, T., Kato, J., Nishida, K., Kaziro, Y. FEBS Lett. (1996)
- SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. Yeow-Fong, L., Lim, L., Manser, E. FEBS Lett. (2005)
- Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK. Ahmed, I., Calle, Y., Sayed, M.A., Kamal, J.M., Rengaswamy, P., Manser, E., Meiners, S., Nur-E-Kamal, A. Biochem. Biophys. Res. Commun. (2004)
- Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. Kiyono, M., Kato, J., Kataoka, T., Kaziro, Y., Satoh, T. J. Biol. Chem. (2000)
- Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner. Kato-Stankiewicz, J., Ueda, S., Kataoka, T., Kaziro, Y., Satoh, T. Biochem. Biophys. Res. Commun. (2001)
- A subset of CD16-natural killer cells without antibody-dependent cellular cytotoxicity function. Schubert, J., Heiken, H., Jacobs, R., Delany, P., Witte, T., Schmidt, R.E. Nat. Immun. Cell Growth Regul. (1990)
- The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors. Teo, M., Tan, L., Lim, L., Manser, E. J. Biol. Chem. (2001)
- Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation. Kato, J., Kaziro, Y., Satoh, T. Biochem. Biophys. Res. Commun. (2000)
- Ack1 Mediates Cdc42-dependent Cell Migration and Signaling to p130Cas. Modzelewska, K., Newman, L.P., Desai, R., Keely, P.J. J. Biol. Chem. (2006)
- Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. Chan, W., Tian, R., Lee, Y.F., Sit, S.T., Lim, L., Manser, E. J. Biol. Chem. (2009)
- Identification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinase. Gu, Y., Lin, Q., Childress, C., Yang, W. J. Biol. Chem. (2004)
- A new procedure for large scale production and freezing of lymphokine activated killer (LAK) cells to be used in adoptive immunotherapy of cancer. Gambacorti-Passerini, C., Radrizzani, M., Rivoltini, L., Marchesi, E., Ravagnani, F., Sciorelli, G., Cascinelli, N., Parmiani, G. Tumori. (1988)