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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Clinical application of living-related conjunctival-limbal allograft.

PURPOSE: To report one successful case of conjunctival-limbal allograft for the treatment of a severe ocular surface disorder. METHODS: Interventional case report. A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation. Oral cyclosporin A and topical autologous serum and corticosteroids were administered. RESULTS: Mucosal epithelial phenotype was maintained in the left eye at most recent examination for more than 3 years after ocular surface reconstruction. CONCLUSION: A total keratinized ocular surface may be treated with the combination of conjunctival and corneal stem cell transplantation.[1]


  1. Clinical application of living-related conjunctival-limbal allograft. Tsubota, K., Shimmura, S., Shinozaki, N., Holland, E.J., Shimazaki, J. Am. J. Ophthalmol. (2002) [Pubmed]
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