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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effects of clofibrate in primary biliary cirrhosis hypercholesterolemia and gallstones.

A patient with primary biliary cirrhosis is reported in whom the administration of clofibrate in a dose of 1 g per day for 2 months resulted in a marked increase in hypercholesterolemia, and endoscopic retrograde cholangiography showed multiple intrahepatic gallstones. The stones disappeared 3 months after stopping clofibrate and starting chenodeoxycholic acid in a dose of 125 mg daily. These observations are discussed in relation to the known effects of clofibrate on bile composition.[1]

References

  1. Effects of clofibrate in primary biliary cirrhosis hypercholesterolemia and gallstones. Summerfield, J.A., Elias, E., Sherlock, S. Gastroenterology (1975) [Pubmed]
 
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