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Disease relevance of Hypercholesterolemia


Psychiatry related information on Hypercholesterolemia


High impact information on Hypercholesterolemia


Chemical compound and disease context of Hypercholesterolemia


Biological context of Hypercholesterolemia


Anatomical context of Hypercholesterolemia


Gene context of Hypercholesterolemia


Analytical, diagnostic and therapeutic context of Hypercholesterolemia


  1. Vitamin E consumption and the risk of coronary heart disease in men. Rimm, E.B., Stampfer, M.J., Ascherio, A., Giovannucci, E., Colditz, G.A., Willett, W.C. N. Engl. J. Med. (1993) [Pubmed]
  2. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. Shepherd, J., Cobbe, S.M., Ford, I., Isles, C.G., Lorimer, A.R., MacFarlane, P.W., McKillop, J.H., Packard, C.J. N. Engl. J. Med. (1995) [Pubmed]
  3. Hyperlipidemia due to oxymetholone therapy. Occurrence in a long-term hemodialysis patient. Reeves, R.D., Morris, M.D., Barbour, G.L. JAMA (1976) [Pubmed]
  4. Proteinuria during long-term captopril therapy. Case, D.B., Atlas, S.A., Mouradian, J.A., Fishman, R.A., Sherman, R.L., Laragh, J.H. JAMA (1980) [Pubmed]
  5. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. Zeiher, A.M., Drexler, H., Saurbier, B., Just, H. J. Clin. Invest. (1993) [Pubmed]
  6. Poststroke dementia : clinical features and risk factors. Barba, R., Martínez-Espinosa, S., Rodríguez-García, E., Pondal, M., Vivancos, J., Del Ser, T. Stroke (2000) [Pubmed]
  7. The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia. Gholami, S.S., Rogers, R., Chang, J., Ho, H.C., Grazziottin, T., Lin, C.S., Lue, T.F. J. Urol. (2003) [Pubmed]
  8. Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs. Leon, C., Hill, J.S., Wasan, K.M. Pharm. Res. (2005) [Pubmed]
  9. Cholesterol in mood and anxiety disorders: review of the literature and new hypotheses. Papakostas, G.I., Ongür, D., Iosifescu, D.V., Mischoulon, D., Fava, M. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2004) [Pubmed]
  10. An intervention to increase physicians' use of adherence-enhancing strategies in managing hypercholesterolemic patients. Casebeer, L.L., Klapow, J.C., Centor, R.M., Stafford, M.A., Renkl, L.A., Mallinger, A.P., Kristofco, R.E. Academic medicine : journal of the Association of American Medical Colleges. (1999) [Pubmed]
  11. Plasma lipid transfer proteins. Tall, A. Annu. Rev. Biochem. (1995) [Pubmed]
  12. Transport of cholesterol. Norum, K.R., Berg, T., Helgerud, P., Drevon, C.A. Physiol. Rev. (1983) [Pubmed]
  13. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Cohen, J., Pertsemlidis, A., Kotowski, I.K., Graham, R., Garcia, C.K., Hobbs, H.H. Nat. Genet. (2005) [Pubmed]
  14. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Abifadel, M., Varret, M., Rabès, J.P., Allard, D., Ouguerram, K., Devillers, M., Cruaud, C., Benjannet, S., Wickham, L., Erlich, D., Derré, A., Villéger, L., Farnier, M., Beucler, I., Bruckert, E., Chambaz, J., Chanu, B., Lecerf, J.M., Luc, G., Moulin, P., Weissenbach, J., Prat, A., Krempf, M., Junien, C., Seidah, N.G., Boileau, C. Nat. Genet. (2003) [Pubmed]
  15. Hormone-replacement therapy compared with simvastatin for postmenopausal women with hypercholesterolemia. Cashin-Hemphill, L., Vailas, L.I. N. Engl. J. Med. (1998) [Pubmed]
  16. Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group. Packard, C.J., O'Reilly, D.S., Caslake, M.J., McMahon, A.D., Ford, I., Cooney, J., Macphee, C.H., Suckling, K.E., Krishna, M., Wilkinson, F.E., Rumley, A., Lowe, G.D. N. Engl. J. Med. (2000) [Pubmed]
  17. The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia. Hunninghake, D.B., Stein, E.A., Dujovne, C.A., Harris, W.S., Feldman, E.B., Miller, V.T., Tobert, J.A., Laskarzewski, P.M., Quiter, E., Held, J. N. Engl. J. Med. (1993) [Pubmed]
  18. Effect of L-arginine on plasminogen-activator inhibitor in hypertensive patients with hypercholesterolemia. Korbut, R., Bieron, K., Gryglewski, R.J. N. Engl. J. Med. (1993) [Pubmed]
  19. Estrogen and progestin compared with simvastatin for hypercholesterolemia in postmenopausal women. Darling, G.M., Johns, J.A., McCloud, P.I., Davis, S.R. N. Engl. J. Med. (1997) [Pubmed]
  20. Compositional protein analysis of high density lipoproteins in hypercholesterolemia by shotgun LC-MS/MS and probabilistic peptide scoring. Heller, M., Schlappritzi, E., Stalder, D., Nuoffer, J.M., Haeberli, A. Mol. Cell Proteomics (2007) [Pubmed]
  21. Hypercholesterolemia in postmenopausal women. Metabolic defects and response to low-dose lovastatin. Arca, M., Vega, G.L., Grundy, S.M. JAMA (1994) [Pubmed]
  22. Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1. Eden, E.R., Patel, D.D., Sun, X.M., Burden, J.J., Themis, M., Edwards, M., Lee, P., Neuwirth, C., Naoumova, R.P., Soutar, A.K. J. Clin. Invest. (2002) [Pubmed]
  23. Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Ting, H.H., Timimi, F.K., Haley, E.A., Roddy, M.A., Ganz, P., Creager, M.A. Circulation (1997) [Pubmed]
  24. Regulation of plasma levels of low-density lipoprotein cholesterol: interpretation of data on low-density lipoprotein turnover in man. Meddings, J.B., Dietschy, J.M. Circulation (1986) [Pubmed]
  25. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Egashira, K., Hirooka, Y., Kai, H., Sugimachi, M., Suzuki, S., Inou, T., Takeshita, A. Circulation (1994) [Pubmed]
  26. Elevated cholesterol and bile acid synthesis in an adult patient with homozygous familial hypercholesterolemia. Reduction by a high glucose diet. Stacpoole, P.W., Grundy, S.M., Swift, L.L., Greene, H.L., Slonim, A.E., Burr, I.M. J. Clin. Invest. (1981) [Pubmed]
  27. Influence of serum cholesterol and other coronary risk factors on vasomotion of angiographically normal coronary arteries. Seiler, C., Hess, O.M., Buechi, M., Suter, T.M., Krayenbuehl, H.P. Circulation (1993) [Pubmed]
  28. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Zeiher, A.M., Drexler, H., Wollschläger, H., Just, H. Circulation (1991) [Pubmed]
  29. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Michelsen, K.S., Wong, M.H., Shah, P.K., Zhang, W., Yano, J., Doherty, T.M., Akira, S., Rajavashisth, T.B., Arditi, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  30. The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery. Mishra, S.K., Watkins, S.C., Traub, L.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  31. Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E. Osuga, J., Yonemoto, M., Yamada, N., Shimano, H., Yagyu, H., Ohashi, K., Harada, K., Kamei, T., Yazaki, Y., Ishibashi, S. J. Clin. Invest. (1998) [Pubmed]
  32. New insights into the genetic regulation of intestinal cholesterol absorption. Lammert, F., Wang, D.Q. Gastroenterology (2005) [Pubmed]
  33. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Maxwell, K.N., Breslow, J.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  34. The lower the better? Reviewing the evidence for more aggressive cholesterol reduction and goal attainment. Stein, E. Atherosclerosis. Supplements. (2002) [Pubmed]
  35. Combination therapy with colestipol and psyllium mucilloid in patients with hyperlipidemia. Spence, J.D., Huff, M.W., Heidenheim, P., Viswanatha, A., Munoz, C., Lindsay, R., Wolfe, B., Mills, D. Ann. Intern. Med. (1995) [Pubmed]
  36. Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Farese, R.V., Ruland, S.L., Flynn, L.M., Stokowski, R.P., Young, S.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  37. Polymorphic DNA haplotypes at the LDL receptor locus. Leitersdorf, E., Chakravarti, A., Hobbs, H.H. Am. J. Hum. Genet. (1989) [Pubmed]
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