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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production.

Two new sesquiterpene esters, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran (1) and 1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-kappaB activation and nitric oxide production. Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-kappaB activation and nitric oxide production.[1]

References

  1. Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production. Jin, H.Z., Hwang, B.Y., Kim, H.S., Lee, J.H., Kim, Y.H., Lee, J.J. J. Nat. Prod. (2002) [Pubmed]
 
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