Chemical Compound Review:
celastrol (4aR,6aS,6aR,14bR)-10- hydroxy-2,4a,6a,6a,9...
Synonyms:
- Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Yang, H., Chen, D., Cui, Q.C., Yuan, X., Dou, Q.P. Cancer Res. (2006)
- Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies. Pinna, G.F., Fiorucci, M., Reimund, J.M., Taquet, N., Arondel, Y., Muller, C.D. Biochem. Biophys. Res. Commun. (2004)
- Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Allison, A.C., Cacabelos, R., Lombardi, V.R., Alvarez, X.A., Vigo, C. Prog. Neuropsychopharmacol. Biol. Psychiatry (2001)
- Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Kiaei, M., Kipiani, K., Petri, S., Chen, J., Calingasan, N.Y., Beal, M.F. Neuro-degenerative diseases. (2005)
- Chronic inhibition of cardiac kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking. Sun, H., Liu, X., Xiong, Q., Shikano, S., Li, M. J. Biol. Chem. (2006)
- Celastrols as inducers of the heat shock response and cytoprotection. Westerheide, S.D., Bosman, J.D., Mbadugha, B.N., Kawahara, T.L., Matsumoto, G., Kim, S., Gu, W., Devlin, J.P., Silverman, R.B., Morimoto, R.I. J. Biol. Chem. (2004)
- Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation. Sassa, H., Kogure, K., Takaishi, Y., Terada, H. Free Radic. Biol. Med. (1994)
- The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Sassa, H., Takaishi, Y., Terada, H. Biochem. Biophys. Res. Commun. (1990)
- Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. Cleren, C., Calingasan, N.Y., Chen, J., Beal, M.F. J. Neurochem. (2005)
- Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction. Bai, J.P., Shi, Y.L., Fang, X., Shi, Q.X. Eur. J. Pharmacol. (2003)
- Inhibition of NF-kappaB activation through targeting IkappaB kinase by celastrol, a quinone methide triterpenoid. Lee, J.H., Koo, T.H., Yoon, H., Jung, H.S., Jin, H.Z., Lee, K., Hong, Y.S., Lee, J.J. Biochem. Pharmacol. (2006)
- Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii. Chang, F.R., Hayashi, K., Chen, I.H., Liaw, C.C., Bastow, K.F., Nakanishi, Y., Nozaki, H., Cragg, G.M., Wu, Y.C., Lee, K.H. J. Nat. Prod. (2003)
- Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography. Buffa Filho, W., Corsino, J., Bolzani, d.a. .S.V., Furlan, M., Pereira, A.M., França, S.C. Phytochemical analysis : PCA. (2002)