Gene Review:
Nfkb1 - nuclear factor of kappa light polypeptide...
Mus musculus
Synonyms:
DNA-binding factor KBF1, EBP-1, NF kappaB1, NF-KB1, NF-kappa-B1 p84/NF-kappa-B1 p98, ...
Michaelidis,
Ménard,
Rücker,
Blackwell,
Pratt,
Wood,
Young,
Stefan Frantz,
Pascual,
Motiwala,
Peter J. Kuhlencordt,
Davis,
Kopp,
Post,
Mercurio,
Clarke,
Uhr,
Charlotte Dienesch,
Breyer,
Ghosh,
Almeida,
Thomas Thum,
Isabel Schmidt,
Bishop,
Niu,
Kitamura,
Perez-Polo,
Zhu,
Mann,
Hao,
Ohl,
Anna Adamek,
Johann Bauersachs,
Murray,
Jochen Tillmanns,
Kömhoff,
Steve Gerondakis,
Bennett,
Yasvinski,
Toliver-Kinsky,
Holsboer,
Shevchenko,
White,
Li,
Manning,
Yull,
Georg Ertl,
May,
- Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Cai, D., Yuan, M., Frantz, D.F., Melendez, P.A., Hansen, L., Lee, J., Shoelson, S.E. Nat. Med. (2005)
- Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Iotsova, V., Caamaño, J., Loy, J., Yang, Y., Lewin, A., Bravo, R. Nat. Med. (1997)
- Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. van Loo, G., De Lorenzi, R., Schmidt, H., Huth, M., Mildner, A., Schmidt-Supprian, M., Lassmann, H., Prinz, M.R., Pasparakis, M. Nat. Immunol. (2006)
- p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout mice. Weih, F., Durham, S.K., Barton, D.S., Sha, W.C., Baltimore, D., Bravo, R. J. Exp. Med. (1997)
- Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. Tomczak, M.F., Erdman, S.E., Davidson, A., Wang, Y.Y., Nambiar, P.R., Rogers, A.B., Rickman, B., Luchetti, D., Fox, J.G., Horwitz, B.H. J. Immunol. (2006)
- NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Kim, S., Millet, I., Kim, H.S., Kim, J.Y., Han, M.S., Lee, M.K., Kim, K.W., Sherwin, R.S., Karin, M., Lee, M.S. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury. Frantz, S., Tillmanns, J., Kuhlencordt, P.J., Schmidt, I., Adamek, A., Dienesch, C., Thum, T., Gerondakis, S., Ertl, G., Bauersachs, J. Am. J. Pathol. (2007)
- The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. Elsharkawy, A.M., Oakley, F., Lin, F., Packham, G., Mann, D.A., Mann, J. J. Hepatol. (2010)
- Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells. Hao, C.M., Yull, F., Blackwell, T., Kömhoff, M., Davis, L.S., Breyer, M.D. J. Clin. Invest. (2000)
- Nuclear factor kappaB/p49 is a negative regulatory factor in nerve growth factor-induced choline acetyltransferase promoter activity in PC12 cells. Toliver-Kinsky, T., Wood, T., Perez-Polo, J.R. J. Neurochem. (2000)
- NF-kappaB-mediated self defense of macrophages faced with bacteria. Kitamura, M. Eur. J. Immunol. (1999)
- Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways. Jaruga, B., Hong, F., Kim, W.H., Sun, R., Fan, S., Gao, B. Am. J. Physiol. Gastrointest. Liver Physiol. (2004)
- Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease. Yu, Z., Zhou, D., Cheng, G., Mattson, M.P. J. Mol. Neurosci. (2000)
- NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Ghosh, S., May, M.J., Kopp, E.B. Annu. Rev. Immunol. (1998)
- Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Massoumi, R., Chmielarska, K., Hennecke, K., Pfeifer, A., Fässler, R. Cell (2006)
- IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Maeda, S., Kamata, H., Luo, J.L., Leffert, H., Karin, M. Cell (2005)
- Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Kamata, H., Honda, S., Maeda, S., Chang, L., Hirata, H., Karin, M. Cell (2005)
- Estrogen withdrawal-induced NF-kappaB activity and bcl-3 expression in breast cancer cells: roles in growth and hormone independence. Pratt, M.A., Bishop, T.E., White, D., Yasvinski, G., Ménard, M., Niu, M.Y., Clarke, R. Mol. Cell. Biol. (2003)
- Influence of 3' half-site sequence of NF-kappa B motifs on the binding of lipopolysaccharide-activatable macrophage NF-kappa B proteins. Muroi, M., Muroi, Y., Yamamoto, K., Suzuki, T. J. Biol. Chem. (1993)
- Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation. Haller, D., Holt, L., Kim, S.C., Schwabe, R.F., Sartor, R.B., Jobin, C. J. Biol. Chem. (2003)
- 18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappa B. Ukil, A., Biswas, A., Das, T., Das, P.K. J. Immunol. (2005)
- Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. Hunter, R.B., Kandarian, S.C. J. Clin. Invest. (2004)
- Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D.U., Jin, R., Jones, J., Cong, R., Franzoso, G. Nature (2001)
- Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Yamamoto, Y., Verma, U.N., Prajapati, S., Kwak, Y.T., Gaynor, R.B. Nature (2003)
- Genetic analyses of NFKB1 and OCA-B function: defects in B cells, serum IgM level, and antibody responses in Nfkb1-/-Oca-b-/- mice. Kim, U., Gunther, C.S., Roeder, R.G. J. Immunol. (2000)
- Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Chen, F.E., Huang, D.B., Chen, Y.Q., Ghosh, G. Nature (1998)
- X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production. Filipe-Santos, O., Bustamante, J., Haverkamp, M.H., Vinolo, E., Ku, C.L., Puel, A., Frucht, D.M., Christel, K., von Bernuth, H., Jouanguy, E., Feinberg, J., Durandy, A., Senechal, B., Chapgier, A., Vogt, G., de Beaucoudrey, L., Fieschi, C., Picard, C., Garfa, M., Chemli, J., Bejaoui, M., Tsolia, M.N., Kutukculer, N., Plebani, A., Notarangelo, L., Bodemer, C., Geissmann, F., Israël, A., Véron, M., Knackstedt, M., Barbouche, R., Abel, L., Magdorf, K., Gendrel, D., Agou, F., Holland, S.M., Casanova, J.L. J. Exp. Med. (2006)
- Proteasome regulation of activation-induced T cell death. Cui, H., Matsui, K., Omura, S., Schauer, S.L., Matulka, R.A., Sonenshein, G.E., Ju, S.T. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Suppression of PTEN expression by NF-kappa B prevents apoptosis. Vasudevan, K.M., Gurumurthy, S., Rangnekar, V.M. Mol. Cell. Biol. (2004)
- betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Lang, V., Janzen, J., Fischer, G.Z., Soneji, Y., Beinke, S., Salmeron, A., Allen, H., Hay, R.T., Ben-Neriah, Y., Ley, S.C. Mol. Cell. Biol. (2003)
- Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. Lou, H., Kaplowitz, N. J. Biol. Chem. (2007)
- NF-kappa B p50/p65 affects the frequency of Ly49 gene expression by NK cells. Pascal, V., Nathan, N.R., Claudio, E., Siebenlist, U., Anderson, S.K. J. Immunol. (2007)
- The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. Singh, K., Chaturvedi, R., Asim, M., Barry, D.P., Lewis, N.D., Vitek, M.P., Wilson, K.T. J. Biol. Chem. (2008)
- IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mercurio, F., Murray, B.W., Shevchenko, A., Bennett, B.L., Young, D.B., Li, J.W., Pascual, G., Motiwala, A., Zhu, H., Mann, M., Manning, A.M. Mol. Cell. Biol. (1999)
- Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription. Steinbrecher, K.A., Wilson, W., Cogswell, P.C., Baldwin, A.S. Mol. Cell. Biol. (2005)
- BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages. Wessells, J., Baer, M., Young, H.A., Claudio, E., Brown, K., Siebenlist, U., Johnson, P.F. J. Biol. Chem. (2004)
- Distinct pathways for NF-kappa B regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetes-prone mouse strains. Liu, J., Beller, D.I. J. Immunol. (2003)
- Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1. Schauvliege, R., Vanrobaeys, J., Schotte, P., Beyaert, R. J. Biol. Chem. (2002)
- NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Wang, H., Hertlein, E., Bakkar, N., Sun, H., Acharyya, S., Wang, J., Carathers, M., Davuluri, R., Guttridge, D.C. Mol. Cell. Biol. (2007)
- Despite inhibition of nuclear localization of NF-kappa B p65, c-Rel, and RelB, 17-beta estradiol up-regulates NF-kappa B signaling in mouse splenocytes: the potential role of Bcl-3. Dai, R., Phillips, R.A., Ahmed, S.A. J. Immunol. (2007)
- A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder. Tamarkin, F.J., Kang, W.S., Cohen, J.J., Wheeler, M.A., Weiss, R.M. Naunyn Schmiedebergs Arch. Pharmacol. (2006)
- Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity. Post, A., Rücker, M., Ohl, F., Uhr, M., Holsboer, F., Almeida, O.F., Michaelidis, T.M. Neuropsychopharmacology (2002)
- TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha. Arsura, M., Wu, M., Sonenshein, G.E. Immunity (1996)
- The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Dejardin, E., Droin, N.M., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z.W., Karin, M., Ware, C.F., Green, D.R. Immunity (2002)
- Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins. Takeuchi, M., Baichwal, V.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Sakurai, T., Maeda, S., Chang, L., Karin, M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Alternate RNA splicing of murine nfkb1 generates a nuclear isoform of the p50 precursor NF-kappa B1 that can function as a transactivator of NF-kappa B-regulated transcription. Grumont, R.J., Fecondo, J., Gerondakis, S. Mol. Cell. Biol. (1994)
- TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. Belich, M.P., Salmerón, A., Johnston, L.H., Ley, S.C. Nature (1999)
- Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Senftleben, U., Cao, Y., Xiao, G., Greten, F.R., Krähn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S.C., Karin, M. Science (2001)
- Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Rudolph, D., Yeh, W.C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A.J., Mak, T.W. Genes Dev. (2000)
- Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter. Lin, S.C., Stavnezer, J. Mol. Cell. Biol. (1996)
- IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy. Tergaonkar, V., Bottero, V., Ikawa, M., Li, Q., Verma, I.M. Mol. Cell. Biol. (2003)
- Normal liver regeneration in p50/nuclear factor kappaB1 knockout mice. DeAngelis, R.A., Kovalovich, K., Cressman, D.E., Taub, R. Hepatology (2001)
- Hepatic ischemic preconditioning in mice is associated with activation of NF-kappaB, p38 kinase, and cell cycle entry. Teoh, N., Dela Pena, A., Farrell, G. Hepatology (2002)
- Interleukin-1 alpha activates an NF-kappaB-like factor in osteoclast-like cells. Jimi, E., Ikebe, T., Takahashi, N., Hirata, M., Suda, T., Koga, T. J. Biol. Chem. (1996)