The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Dramatic developmental changes in larval knockdown response enhance genetic sexing based on DDT resistance in Anopheles stephensi (Diptera: Culicidae).

Genetic sexing systems based on a conditional lethal require good discrimination between the different phenotypes. DDT resistance in the early instars of Anopheles stephensi Liston is not a good candidate when based on mortality, but this study shows that the knockdown response gives exceptional discrimination between heterozygous resistant and homozygous susceptible individuals. One- and two-day-old larvae of the DlDDT strain showed high (417-fold) resistance to knockdown by DDT, but very low resistance to mortality (3.3-fold). This changes with the onset of the third instar, so that by the fourth instar, mortality resistance is high (108-fold) and knockdown resistance is low (6.5-fold). Susceptibility to DDT decreases from first to fourth instar in the susceptible strain by 443-fold for knockdown and 15-fold for mortality and in the resistant strain by 8.5-fold for knockdown and 491-fold for mortality. The DDT knockdown response in young larvae was successfully used to identify two Y-autosome translocations linked to the resistance gene, DDT. T(Y-3)69 and T(Y-3)72 gave recombination values between the translocation breakpoint and the DDT locus of 4.1 and 10.1 crossover units, respectively. T(Y-3)69 proved to be an adequate genetic sexing system for laboratory studies.[1]


WikiGenes - Universities