The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN23485     1-[(2R,5S)-5- (hydroxymethyl)oxolan-2-yl]- 5...

Synonyms: CHEMBL444314, AG-F-15911, ddT & GM-CSF, ANW-44704, CHEBI:186554, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DDT

  • CONCLUSIONS: Our data do not support the hypothesis that exposure to DDT and PCBs increases the risk of breast cancer [1].
  • DDT-induced feminization of gull embryos [2].
  • IMPLICATIONS: These results may indicate that DDT can cause pancreatic cancer in humans under circumstances of heavy and prolonged exposure [3].
  • INTERPRETATION: The findings strongly suggest that DDT use increases preterm births, which is a major contributor to infant mortality [4].
  • Several studies suggest that there may be an association between the agricultural use of the organochlorine 1,1,1-trichloro-2,2'bis(p-chlorophenyl)ethane (DDT) and increased risk of non-Hodgkin lymphoma [5].

Psychiatry related information on DDT

  • DDT-treated rats had a significantly lower mammary tumor incidence, prolonged tumor latency period, and fewer tumors per rat than did the control group [6].
  • EDA-imprinted sol-gels, deposited as films on glass microscope slides, were shown to quantitatively detect DDT in water to a limit-of-detection of 50 ppt with a response time of <60 s [7].
  • Avian species thus reflect biological magnification of BHC and DDT residues, presumably due to their food habits [8].
  • These findings are discussed in relation to previous reports of the behavior of An. minimus s.l., particularly in light of suggestions that An. minimus s.l. has changed its feeding behavior in response to DDT spraying [9].
  • Increased spontaneous locomotor activity in the fiddler crab, Uca pugilator, after exposure to a sublethal concentration of DDT [10].

High impact information on DDT


Chemical compound and disease context of DDT


Biological context of DDT

  • The chlorinated hydrocarbons DDT and PCB's (polychlorinated biphenyls), ubiquitous pollutants of the marine environment, have been observed to reduce the cell division rate of marine phytoplankton, thereby indirectly reducing the total photosynthetic carbon fixation in treated cultures [19].
  • Increased risks of NHL were also observed among those with occupational exposure to organochlorine insecticides, such as DDT [1.82 (1.04-3.2)] and organic solvents [1.35 (1.06-1.7)], and to other chemicals typically encountered in the agricultural, forestry, or wood products industries [20].
  • DDT -- a novel domain in different transcription and chromosome remodeling factors [21].
  • Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins [21].
  • Thus we must reject the hypothesis that the insertion of a long terminal repeat leads to DDT susceptibility in Drosophila [22].

Anatomical context of DDT


Associations of DDT with other chemical compounds


Gene context of DDT

  • The interaction of Acf1 with ISWI requires a DDT domain, which has been found in a variety of transcription and chromatin-remodeling factors [31].
  • High expression of Cyp6g1, a cytochrome P450 gene, does not necessarily confer DDT resistance in Drosophila melanogaster [32].
  • The level of expression of the Cyp6a2 gene is much higher in the DDT-resistant 91-R strain than in the susceptible 91-C strain of Drosophila melanogaster (Waters et al. (1992b) Proc. Natl. Acad. Sci. USA, 89, 4855-4859) [33].
  • PR mRNA expression in MCF-7 cells was up regulated after administration of COU and DDT, whereas treatment with BPA and OCT did not effect PR mRNA expression [34].
  • Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides [35].

Analytical, diagnostic and therapeutic context of DDT


  1. Plasma organochlorine levels and the risk of breast cancer. Hunter, D.J., Hankinson, S.E., Laden, F., Colditz, G.A., Manson, J.E., Willett, W.C., Speizer, F.E., Wolff, M.S. N. Engl. J. Med. (1997) [Pubmed]
  2. DDT-induced feminization of gull embryos. Fry, D.M., Toone, C.K. Science (1981) [Pubmed]
  3. DDT and related compounds and risk of pancreatic cancer. Garabrant, D.H., Held, J., Langholz, B., Peters, J.M., Mack, T.M. J. Natl. Cancer Inst. (1992) [Pubmed]
  4. Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Longnecker, M.P., Klebanoff, M.A., Zhou, H., Brock, J.W. Lancet (2001) [Pubmed]
  5. A nested case-control study of non-Hodgkin lymphoma and serum organochlorine residues. Rothman, N., Cantor, K.P., Blair, A., Bush, D., Brock, J.W., Helzlsouer, K., Zahm, S.H., Needham, L.L., Pearson, G.R., Hoover, R.N., Comstock, G.W., Strickland, P.T. Lancet (1997) [Pubmed]
  6. Protection by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) against mammary tumors and leukemia during prolonged feeding of 7,12-dimethylbenz(a)anthracene to female rats. Silinskas, K.C., Okey, A.B. J. Natl. Cancer Inst. (1975) [Pubmed]
  7. Development and characterization of molecularly imprinted sol-gel materials for the selective detection of DDT. Graham, A.L., Carlson, C.A., Edmiston, P.L. Anal. Chem. (2002) [Pubmed]
  8. Organochlorine pesticide residues in some Indian wild birds. Kaphalia, B.S., Husain, M.M., Seth, T.D., Kumar, A., Murti, C.R. Pesticides monitoring journal. (1981) [Pubmed]
  9. Biting behavior and seasonal variation in the abundance of Anopheles minimus species A and C in Thailand. Rwegoshora, R.T., Sharpe, R.G., Baisley, K.J., Kittayapong, P. Southeast Asian J. Trop. Med. Public Health (2002) [Pubmed]
  10. Increased spontaneous locomotor activity in the fiddler crab, Uca pugilator, after exposure to a sublethal concentration of DDT. Fingerman, S.W., Van Meter, C., Fingerman, M. Bulletin of environmental contamination and toxicology. (1979) [Pubmed]
  11. Massachusetts Department of Public Health. Bats, rabies and DDT. Wells, L.F., Girard, K.F. N. Engl. J. Med. (1977) [Pubmed]
  12. Genetic recombination and directional selection for DDT resistance in Drosophila melanogaster. Flexon, P.B., Rodell, C.F. Nature (1982) [Pubmed]
  13. Asymmetrical currents and sodium currents in Ranvier nodes exposed to DDT. Dubois, J.M., Bergman, C. Nature (1977) [Pubmed]
  14. Oxidation of persistent environmental pollutants by a white rot fungus. Bumpus, J.A., Tien, M., Wright, D., Aust, S.D. Science (1985) [Pubmed]
  15. Blood levels of organochlorine residues and risk of breast cancer. Wolff, M.S., Toniolo, P.G., Lee, E.W., Rivera, M., Dubin, N. J. Natl. Cancer Inst. (1993) [Pubmed]
  16. Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. Jaju, M., Beard, W.A., Wilson, S.H. J. Biol. Chem. (1995) [Pubmed]
  17. Zidovudine (azido dideoxythymidine) inhibits characteristic early alterations of lymphoid cell populations in retrovirus-induced murine AIDS. Portnoi, D., Stall, A.M., Schwartz, D., Merigan, T.C., Herzenberg, L.A., Basham, T. J. Immunol. (1990) [Pubmed]
  18. Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2',3'-dideoxynucleosides. Gao, W.Y., Johns, D.G., Mitsuya, H. Mol. Pharmacol. (1994) [Pubmed]
  19. Chlorinated hydrocarbon pollutants and photosynthesis of marine phytoplankton: a reassessment. Fisher, N.S. Science (1975) [Pubmed]
  20. Soft tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in western Washington. Woods, J.S., Polissar, L., Severson, R.K., Heuser, L.S., Kulander, B.G. J. Natl. Cancer Inst. (1987) [Pubmed]
  21. DDT -- a novel domain in different transcription and chromosome remodeling factors. Doerks, T., Copley, R., Bork, P. Trends Biochem. Sci. (2001) [Pubmed]
  22. Noninvolvement of the long terminal repeat of transposable element 17.6 in insecticide resistance in Drosophila. Delpuech, J.M., Aquadro, C.F., Roush, R.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  23. Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines. Shekhar, P.V., Werdell, J., Basrur, V.S. J. Natl. Cancer Inst. (1997) [Pubmed]
  24. Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group. Porta, M., Malats, N., Jariod, M., Grimalt, J.O., Rifà, J., Carrato, A., Guarner, L., Salas, A., Santiago-Silva, M., Corominas, J.M., Andreu, M., Real, F.X. Lancet (1999) [Pubmed]
  25. Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic reticulum Ca2+ transport ATPase mediate resistance to thapsigargin in thapsigargin-resistant hamster cells. Yu, M., Zhong, L., Rishi, A.K., Khadeer, M., Inesi, G., Hussain, A., Zhang, L. J. Biol. Chem. (1998) [Pubmed]
  26. Effects of aphidicolin and/or 2',3'-dideoxythymidine on DNA repair induced in HeLa cells by four types of DNA-damaging agents. Yamada, K., Hanaoka, F., Yamada, M. J. Biol. Chem. (1985) [Pubmed]
  27. Insecticidal activity of pyrethroids on insects of medical importance. Zerba, E. Parasitol. Today (Regul. Ed.) (1988) [Pubmed]
  28. Preferential replication of repeated DNA sequences in nuclei isolated from soybean cells grown in suspension culture. Caboche, M., Lark, K.G. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  29. Metabolism of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane, and 1-chloro-2,2-bis(p-chlorophenyl)ethene in the hamster. Gold, B., Brunk, G. Cancer Res. (1983) [Pubmed]
  30. Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase. Bourdais, J., Biondi, R., Sarfati, S., Guerreiro, C., Lascu, I., Janin, J., Véron, M. J. Biol. Chem. (1996) [Pubmed]
  31. Binding of Acf1 to DNA involves a WAC motif and is important for ACF-mediated chromatin assembly. Fyodorov, D.V., Kadonaga, J.T. Mol. Cell. Biol. (2002) [Pubmed]
  32. High expression of Cyp6g1, a cytochrome P450 gene, does not necessarily confer DDT resistance in Drosophila melanogaster. Kuruganti, S., Lam, V., Zhou, X., Bennett, G., Pittendrigh, B.R., Ganguly, R. Gene (2007) [Pubmed]
  33. Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster. Maitra, S., Dombrowski, S.M., Waters, L.C., Ganguly, R. Gene (1996) [Pubmed]
  34. Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. Diel, P., Olff, S., Schmidt, S., Michna, H. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
  35. Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides. Pittendrigh, B., Reenan, R., ffrench-Constant, R.H., Ganetzky, B. Mol. Gen. Genet. (1997) [Pubmed]
  36. Cross-sectional study of a community with exceptional exposure to DDT. Kreiss, K., Zack, M.M., Kimbrough, R.D., Needham, L.L., Smrek, A.L., Jones, B.T. JAMA (1981) [Pubmed]
  37. A case-control study of self-reported exposures to pesticides and pancreas cancer in southeastern Michigan. Fryzek, J.P., Garabrant, D.H., Harlow, S.D., Severson, R.K., Gillespie, B.W., Schenk, M., Schottenfeld, D. Int. J. Cancer (1997) [Pubmed]
  38. Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiae. Ortelli, F., Rossiter, L.C., Vontas, J., Ranson, H., Hemingway, J. Biochem. J. (2003) [Pubmed]
  39. Carcinogenicity of DDT (dichlorodiphenyl trichloroethane) in pure inbred Swiss mice. Kashyap, S.K., Nigam, S.K., Karnik, A.B., Gupta, R.C., Chatterjee, S.K. Int. J. Cancer (1977) [Pubmed]
WikiGenes - Universities