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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Anopheles


Psychiatry related information on Anopheles

  • We have isolated AgArr1, an arrestin-encoding cDNA from the malaria vector mosquito, Anopheles gambiae, where olfaction is critical for vectorial capacity [6].

High impact information on Anopheles

  • Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae [7].
  • Anopheles mosquitoes are major vectors of human malaria in Africa. Large variation exists in the ability of mosquitoes to serve as vectors and to transmit malaria parasites, but the molecular mechanisms that determine vectorial capacity remain poorly understood [7].
  • We characterize a novel hemocyte-specific acute phase glycoprotein from the malaria vector, Anopheles gambiae [8].
  • Seven of these 17 isoforms are present in the distantly-related Dipteran Anopheles gambiae, suggesting that the properties of specific isoforms are likely to be critical to lola function [9].
  • A new insect member of the STAT family of transcription factors (Ag-STAT) has been cloned from the human malaria vector Anopheles gambiae [10].

Chemical compound and disease context of Anopheles


Biological context of Anopheles


Anatomical context of Anopheles


Associations of Anopheles with chemical compounds


Gene context of Anopheles

  • Similar inserts seem to exist in the Start1 homologues of Drosophila pseudoobscura and Anopheles gambiae, but not in the homologous protein of the urochordate Ciona intestinalis [30].
  • As a first step we have cloned and functionally expressed the gene that is the orthologue of DmTrx-2 in the malaria mosquito Anopheles gambiae [31].
  • Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect [32].
  • Thioredoxin reductase from the malaria mosquito Anopheles gambiae [33].
  • We report here the characterization of a complete cDNA sequence encoding a LSP-1-like protein from a lower dipteran insect, the malaria mosquito Anopheles gambiae [34].

Analytical, diagnostic and therapeutic context of Anopheles


  1. Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes. Hallett, R.L., Sutherland, C.J., Alexander, N., Ord, R., Jawara, M., Drakeley, C.J., Pinder, M., Walraven, G., Targett, G.A., Alloueche, A. Antimicrob. Agents Chemother. (2004) [Pubmed]
  2. Drosophila yolk protein produced in E. coli is accumulated by mosquito ovaries. Bownes, M., Hurd, H., Büsgen, T., Servay, D., Alvis, S., Popovic, B., Bruce, S., Burns, I., Rothwell, K., Walkinshaw, M. Insect Mol. Biol. (2002) [Pubmed]
  3. Cloning and characterization of a novel gene which encodes a protein interacting with the mitosis-associated kinase-like protein NTKL. Di, Y., Li, J., Fang, J., Xu, Z., He, X., Zhang, F., Ling, J., Li, X., Xu, D., Li, L., Li, Y.Y., Huo, K. J. Hum. Genet. (2003) [Pubmed]
  4. The Anopheles gambiae tryptophan oxygenase gene expressed from a baculovirus promoter complements Drosophila melanogaster vermilion. Besansky, N.J., Mukabayire, O., Benedict, M.Q., Rafferty, C.S., Hamm, D.M., Mcnitt, L. Insect Biochem. Mol. Biol. (1997) [Pubmed]
  5. Efficacy of etofenprox against insecticide susceptible and resistant mosquito strains containing characterized resistance mechanisms. Hemingway, J. Med. Vet. Entomol. (1995) [Pubmed]
  6. Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae. Merrill, C.E., Riesgo-Escovar, J., Pitts, R.J., Kafatos, F.C., Carlson, J.R., Zwiebel, L.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae. Blandin, S., Shiao, S.H., Moita, L.F., Janse, C.J., Waters, A.P., Kafatos, F.C., Levashina, E.A. Cell (2004) [Pubmed]
  8. Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae. Levashina, E.A., Moita, L.F., Blandin, S., Vriend, G., Lagueux, M., Kafatos, F.C. Cell (2001) [Pubmed]
  9. Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila. Goeke, S., Greene, E.A., Grant, P.K., Gates, M.A., Crowner, D., Aigaki, T., Giniger, E. Nat. Neurosci. (2003) [Pubmed]
  10. Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection. Barillas-Mury, C., Han, Y.S., Seeley, D., Kafatos, F.C. EMBO J. (1999) [Pubmed]
  11. A prospective study of the effects of ultralow volume (ULV) aerial application of malathion on epidemic Plasmodium falciparum malaria. I. Study design and perspective. Eliason, D.A., Joseph, V.R., Karam, J. Am. J. Trop. Med. Hyg. (1975) [Pubmed]
  12. Integrins of Anopheles gambiae and a putative role of a new beta integrin, BINT2, in phagocytosis of E. coli. Moita, L.F., Vriend, G., Mahairaki, V., Louis, C., Kafatos, F.C. Insect Biochem. Mol. Biol. (2006) [Pubmed]
  13. Comparative toxicity of permethrin- and bifenthrin-treated cloth fabric for Anopheles farauti and Aedes aegypti. Frances, S.P., Watson, K., Constable, B.G. J. Am. Mosq. Control Assoc. (2003) [Pubmed]
  14. Field evaluation of repellents containing deet and AI3-37220 against Anopheles koliensis in Papua New Guinea. Frances, S.P., Cooper, R.D., Popat, S., Beebe, N.W. J. Am. Mosq. Control Assoc. (2001) [Pubmed]
  15. Efficacy of Bacillus thuringiensis israelensis, Bacillus sphaericus and temephos for managing Anopheles larvae in Eritrea. Shililu, J.I., Tewolde, G.M., Brantly, E., Githure, J.I., Mbogo, C.M., Beier, J.C., Fusco, R., Novak, R.J. J. Am. Mosq. Control Assoc. (2003) [Pubmed]
  16. Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis. Shinoda, T., Itoyama, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. Cloning and localization of a glutathione S-transferase class I gene from Anopheles gambiae. Ranson, H., Cornel, A.J., Fournier, D., Vaughan, A., Collins, F.H., Hemingway, J. J. Biol. Chem. (1997) [Pubmed]
  18. Construction of modular and versatile plasmid vectors for the high-level expression of single or multiple genes in insects and insect cell lines. Huynh, C.Q., Zieler, H. J. Mol. Biol. (1999) [Pubmed]
  19. Functional conservation of the fruitless male sex-determination gene across 250 Myr of insect evolution. Gailey, D.A., Billeter, J.C., Liu, J.H., Bauzon, F., Allendorfer, J.B., Goodwin, S.F. Mol. Biol. Evol. (2006) [Pubmed]
  20. A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection. Peterson, T.M., Luckhart, S. Free Radic. Biol. Med. (2006) [Pubmed]
  21. The salivary catechol oxidase/peroxidase activities of the mosquito Anopheles albimanus. Ribeiro, J.M., Nussenzveig, R.H. J. Exp. Biol. (1993) [Pubmed]
  22. Comparative analysis of promoters for transient gene expression in cultured mosquito cells. Zhao, Y.G., Eggleston, P. Insect Mol. Biol. (1999) [Pubmed]
  23. Plasmodium falciparum ookinete invasion of the midgut epithelium of Anopheles stephensi is consistent with the Time Bomb model. Baton, L.A., Ranford-Cartwright, L.C. Parasitology (2004) [Pubmed]
  24. Mosquito natriuretic peptide identified as a calcitonin-like diuretic hormone in Anopheles gambiae (Giles). Coast, G.M., Garside, C.S., Webster, S.G., Schegg, K.M., Schooley, D.A. J. Exp. Biol. (2005) [Pubmed]
  25. The chemotherapy of rodent malaria, XXXII. The influence of p-aminobenzoic acid on the transmission of Plasmodium yoelii and P. berghei by Anopheles stephensi. Peters, W., Ramkaran, A.E. Ann. Trop. Med. Parasitol. (1980) [Pubmed]
  26. The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family. Ranson, H., Collins, F., Hemingway, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  27. Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase. Rossi, F., Garavaglia, S., Giovenzana, G.B., Arcà, B., Li, J., Rizzi, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  28. Cloning and characterization of four Anopheles gambiae serpin isoforms, differentially induced in the midgut by Plasmodium berghei invasion. Danielli, A., Kafatos, F.C., Loukeris, T.G. J. Biol. Chem. (2003) [Pubmed]
  29. A sensitive core region in the structure of glutathione S-transferases. Wongsantichon, J., Harnnoi, T., Ketterman, A.J. Biochem. J. (2003) [Pubmed]
  30. The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis. Roth, G.E., Gierl, M.S., Vollborn, L., Meise, M., Lintermann, R., Korge, G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  31. Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2. Bauer, H., Kanzok, S.M., Schirmer, R.H. J. Biol. Chem. (2002) [Pubmed]
  32. Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect. Qiu, F., Lakey, A., Agianian, B., Hutchings, A., Butcher, G.W., Labeit, S., Leonard, K., Bullard, B. Biochem. J. (2003) [Pubmed]
  33. Thioredoxin reductase from the malaria mosquito Anopheles gambiae. Bauer, H., Gromer, S., Urbani, A., Schnölzer, M., Schirmer, R.H., Müller, H.M. Eur. J. Biochem. (2003) [Pubmed]
  34. Molecular cloning and expression of a hexamerin cDNA from the malaria mosquito, Anopheles gambiae. Zakharkin, S.O., Gordadze, A.V., Korochkina, S.E., Mathiopoulos, K.D., Della Torre, A., Benes, H. Eur. J. Biochem. (1997) [Pubmed]
  35. A gut-specific serine protease from the malaria vector Aanopheles gambiae is downregulated after blood ingestion. Shen, Z., Edwards, M.J., Jacobs-Lorena, M. Insect Mol. Biol. (2000) [Pubmed]
  36. Infection of Anopheles darlingi fed on patients with Plasmodium falciparum before and after treatment with quinine or quinine plus tetracycline. Klein, T.A., Tada, M.S., Lima, J.B. Am. J. Trop. Med. Hyg. (1991) [Pubmed]
  37. Crystallization of agGST1-6, a recombinant glutathione S-transferase from a DDT-resistant strain of Anopheles gambiae. Roberts, P.H., Zhou, X., Holmes, A.M., Ranson, H., Small, G., Hemingway, J., Ng, J.D., Chen, L., Meehan, E.J. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
  38. Antisense suppression of the putative ribosomal protein S3A gene disrupts ovarian development in Drosophila melanogaster. Reynaud, E., Bolshakov, V.N., Barajas, V., Kafatos, F.C., Zurita, M. Mol. Gen. Genet. (1997) [Pubmed]
  39. Variation in cuticular hydrocarbons among strains of Anopheles (Cellia) stephensi Liston possibly related to prior insecticide exposure. Anyanwu, G.I., Davies, D.H., Molyneux, D.H., Phillips, A. Ann. Trop. Med. Parasitol. (1997) [Pubmed]
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