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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Reversible restrictive cardiomyopathy due to light-chain deposition disease.

Systemic light-chain deposition due to plasma cell dyscrasias manifests as a form of restrictive cardiomyopathy with diastolic ventricular dysfunction. Although these manifestations are likely to be cardiac amyloidosis, whether these pathological conditions are reversible after treatment of the underlying plasma cell disorders is unknown. To our knowledge, we describe the first patient with cardiac light-chain deposition due to multiple myeloma in whom echocardiographic and biochemical factors of cardiac function were ameliorated dramatically after remission of this disorder. We emphasize that restrictive cardiomyopathy due to light-chain deposition may be reversible and have a relatively better prognosis after remission of plasma cell dyscrasias.[1]


  1. Reversible restrictive cardiomyopathy due to light-chain deposition disease. Nakamura, M., Satoh, M., Kowada, S., Satoh, H., Tashiro, A., Sato, F., Masuda, T., Hiramori, K. Mayo Clin. Proc. (2002) [Pubmed]
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